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Murcko scaffold

Ring system with 3 rings and 21 atoms

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
9
With full pages
1
Scaffold SMILES

O=C(C=Cc1cccs1)Nc1cc(-c2ccccc2)cs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1cccs1)Nc1cc(-c2ccccc2)cs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

Methyl 4-(4-methylphenyl)-2-{[3-(2-thienyl)acryloyl]amino}-3-thiophenecarboxylate chemical structure, C20H17NO3S2, CAS 545358-60-9
Methyl 4-(4-methylphenyl)-2-{[3-(2-thienyl)acryloyl]amino}-3-thiophenecarboxylate
CAS 545358-60-9C20H17NO3S2
Methyl 4-phenyl-2-{[(2E)-3-(thiophen-2-yl)prop-2-enoyl]amino}thiophene-3-carboxylate chemical structure, C19H15NO3S2, CAS 379245-88-2
Methyl 4-phenyl-2-{[(2E)-3-(thiophen-2-yl)prop-2-enoyl]amino}thiophene-3-carboxylate
CAS 379245-88-2C19H15NO3S2
4-(4-Isopropylphenyl)-2-{[3-(2-thienyl)acryloyl]amino}-3-thiophenecarboxylic acid chemical structure, C21H19NO3S2, CAS 315677-70-4
4-(4-Isopropylphenyl)-2-{[3-(2-thienyl)acryloyl]amino}-3-thiophenecarboxylic acid
CAS 315677-70-4C21H19NO3S2
4-Phenyl-2-[(2E)-3-(thiophen-2-yl)prop-2-enamido]thiophene-3-carboxylic acid chemical structure, C18H13NO3S2, CAS 1815599-41-7
4-Phenyl-2-[(2E)-3-(thiophen-2-yl)prop-2-enamido]thiophene-3-carboxylic acid
CAS 1815599-41-7C18H13NO3S2
(E)-Ethyl 2-(2-cyano-3-(thiophen-2-yl)acrylamido)-4-(4-methoxyphenyl)thiophene-3-carboxylate chemical structure, C22H18N2O4S2, CAS 373610-32-3
(E)-Ethyl 2-(2-cyano-3-(thiophen-2-yl)acrylamido)-4-(4-methoxyphenyl)thiophene-3-carboxylate
CAS 373610-32-3C22H18N2O4S2
(E)-Ethyl 2-(2-cyano-3-(thiophen-2-yl)acrylamido)-4-phenylthiophene-3-carboxylate chemical structure, C21H16N2O3S2, CAS 327075-57-0
(E)-Ethyl 2-(2-cyano-3-(thiophen-2-yl)acrylamido)-4-phenylthiophene-3-carboxylate
CAS 327075-57-0C21H16N2O3S2
(E)-Ethyl 2-(2-cyano-3-(thiophen-2-yl)acrylamido)-4-(p-tolyl)thiophene-3-carboxylate chemical structure, C22H18N2O3S2, CAS 327075-73-0
(E)-Ethyl 2-(2-cyano-3-(thiophen-2-yl)acrylamido)-4-(p-tolyl)thiophene-3-carboxylate
CAS 327075-73-0C22H18N2O3S2
(E)-Ethyl 2-(3-(thiophen-2-yl)acrylamido)-4-(p-tolyl)thiophene-3-carboxylate chemical structure, C21H19NO3S2, CAS 314244-92-3
(E)-Ethyl 2-(3-(thiophen-2-yl)acrylamido)-4-(p-tolyl)thiophene-3-carboxylate
CAS 314244-92-3C21H19NO3S2
tert-Butyl 4-phenyl-2-[(2E)-3-(thiophen-2-yl)prop-2-enamido]thiophene-3-carboxylate chemical structure, C22H21NO3S2, CAS 2138805-83-9
tert-Butyl 4-phenyl-2-[(2E)-3-(thiophen-2-yl)prop-2-enamido]thiophene-3-carboxylate
CAS 2138805-83-9C22H21NO3S2