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Murcko scaffold

Ring system with 3 rings and 21 atoms

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
13
With full pages
1
Scaffold SMILES

O=C(C=Cc1ccco1)Nc1cc(-c2ccccc2)cs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccco1)Nc1cc(-c2ccccc2)cs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

2-[[(E)-3-(Furan-2-yl)prop-2-enoyl]amino]-4-phenylthiophene-3-carboxylic acid chemical structure, C18H13NO4S, CAS 312584-57-9
2-[[(E)-3-(Furan-2-yl)prop-2-enoyl]amino]-4-phenylthiophene-3-carboxylic acid
CAS 312584-57-9C18H13NO4S
Isopropyl 4-(4-fluorophenyl)-2-[(3-{5-nitro-2-furyl}acryloyl)amino]-5-methyl-3-thiophenecarboxylate chemical structure, C22H19FN2O6S, CAS 515123-13-4
Isopropyl 4-(4-fluorophenyl)-2-[(3-{5-nitro-2-furyl}acryloyl)amino]-5-methyl-3-thiophenecarboxylate
CAS 515123-13-4C22H19FN2O6S
(E)-N-(3-Cyano-5-methyl-4-phenylthiophen-2-yl)-3-(5-nitrofuran-2-yl)prop-2-enamide chemical structure, C19H13N3O4S, CAS 515122-54-0
(E)-N-(3-Cyano-5-methyl-4-phenylthiophen-2-yl)-3-(5-nitrofuran-2-yl)prop-2-enamide
CAS 515122-54-0C19H13N3O4S
Methyl 4-(4-fluorophenyl)-2-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]thiophene-3-carboxylate chemical structure, C19H14FNO4S, CAS 546097-91-0
Methyl 4-(4-fluorophenyl)-2-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]thiophene-3-carboxylate
CAS 546097-91-0C19H14FNO4S
4-(4-Bromophenyl)-2-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]thiophene-3-carboxylic acid chemical structure, C18H12BrNO4S, CAS 312584-59-1
4-(4-Bromophenyl)-2-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]thiophene-3-carboxylic acid
CAS 312584-59-1C18H12BrNO4S
(E)-Ethyl 2-(2-cyano-3-(furan-2-yl)acrylamido)-4-(4-methoxyphenyl)thiophene-3-carboxylate chemical structure, C22H18N2O5S, CAS 373615-83-9
(E)-Ethyl 2-(2-cyano-3-(furan-2-yl)acrylamido)-4-(4-methoxyphenyl)thiophene-3-carboxylate
CAS 373615-83-9C22H18N2O5S
(E)-Ethyl 2-(2-cyano-3-(furan-2-yl)acrylamido)-4-(p-tolyl)thiophene-3-carboxylate chemical structure, C22H18N2O4S, CAS 374095-66-6
(E)-Ethyl 2-(2-cyano-3-(furan-2-yl)acrylamido)-4-(p-tolyl)thiophene-3-carboxylate
CAS 374095-66-6C22H18N2O4S
(E)-Ethyl 2-(3-(furan-2-yl)acrylamido)-4-phenylthiophene-3-carboxylate chemical structure, C20H17NO4S, CAS 304684-76-2
(E)-Ethyl 2-(3-(furan-2-yl)acrylamido)-4-phenylthiophene-3-carboxylate
CAS 304684-76-2C20H17NO4S
Ethyl 4-(4-tert-butylphenyl)-2-{[3-(2-furyl)acryloyl]amino}-3-thiophenecarboxylate chemical structure, C24H25NO4S, CAS 315683-94-4
Ethyl 4-(4-tert-butylphenyl)-2-{[3-(2-furyl)acryloyl]amino}-3-thiophenecarboxylate
CAS 315683-94-4C24H25NO4S
(E)-Ethyl 2-(2-cyano-3-(5-methylfuran-2-yl)acrylamido)-4-(4-methoxyphenyl)thiophene-3-carboxylate chemical structure, C23H20N2O5S, CAS 374092-06-5
(E)-Ethyl 2-(2-cyano-3-(5-methylfuran-2-yl)acrylamido)-4-(4-methoxyphenyl)thiophene-3-carboxylate
CAS 374092-06-5C23H20N2O5S
(E)-Ethyl 4-(4-chlorophenyl)-2-(3-(furan-2-yl)acrylamido)thiophene-3-carboxylate chemical structure, C20H16ClNO4S, CAS 315676-37-0
(E)-Ethyl 4-(4-chlorophenyl)-2-(3-(furan-2-yl)acrylamido)thiophene-3-carboxylate
CAS 315676-37-0C20H16ClNO4S
Methyl 4-(4-chlorophenyl)-2-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]-5-methylthiophene-3-carboxylate chemical structure, C20H16ClNO4S, CAS 514838-41-6
Methyl 4-(4-chlorophenyl)-2-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]-5-methylthiophene-3-carboxylate
CAS 514838-41-6C20H16ClNO4S
Propan-2-yl 2-{[(2E)-3-(5-methylfuran-2-yl)prop-2-enoyl]amino}-4-phenylthiophene-3-carboxylate chemical structure, C22H21NO4S, CAS 765289-34-7
Propan-2-yl 2-{[(2E)-3-(5-methylfuran-2-yl)prop-2-enoyl]amino}-4-phenylthiophene-3-carboxylate
CAS 765289-34-7C22H21NO4S