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Murcko scaffold

Ring system with 3 rings and 21 atoms

25 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
25
With full pages
5
Scaffold SMILES

O=C(CSc1nnc[nH]1)Nc1nnc(-c2ccccc2)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc[nH]1)Nc1nnc(-c2ccccc2)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

N-(5-(2,4-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C15H16N6O3S2, CAS 394232-99-6
N-(5-(2,4-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 394232-99-6C15H16N6O3S2
N-[5-(2,5-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C15H16N6O3S2, CAS 394232-28-1
N-[5-(2,5-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
CAS 394232-28-1C15H16N6O3S2
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(p-tolyl)-1,3,4-thiadiazol-2-yl)propanamide chemical structure, C15H16N6OS2, CAS 394235-27-9
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(p-tolyl)-1,3,4-thiadiazol-2-yl)propanamide
CAS 394235-27-9C15H16N6OS2
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(m-tolyl)-1,3,4-thiadiazol-2-yl)acetamide chemical structure, C14H14N6OS2, CAS 394231-20-0
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(m-tolyl)-1,3,4-thiadiazol-2-yl)acetamide
CAS 394231-20-0C14H14N6OS2
2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(5-phenyl-1,3,4-thiadiazol-2-yl)propanamide chemical structure, C14H14N6OS2, CAS 394234-04-9
2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(5-phenyl-1,3,4-thiadiazol-2-yl)propanamide
CAS 394234-04-9C14H14N6OS2
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(m-tolyl)-1,3,4-thiadiazol-2-yl)propanamide chemical structure, C15H16N6OS2, CAS 394235-05-3
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(m-tolyl)-1,3,4-thiadiazol-2-yl)propanamide
CAS 394235-05-3C15H16N6OS2
N-[5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)thio]butanamide chemical structure, C15H15ClN6OS2, CAS 394237-09-3
N-[5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)thio]butanamide
CAS 394237-09-3C15H15ClN6OS2
2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(5-phenyl-1,3,4-thiadiazol-2-yl)acetamide chemical structure, C13H12N6OS2, CAS 394234-71-0
2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
CAS 394234-71-0C13H12N6OS2
N-(5-(4-Methoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide chemical structure, C15H16N6O2S2, CAS 394235-64-4
N-(5-(4-Methoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide
CAS 394235-64-4C15H16N6O2S2
2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[5-(3-nitrophenyl)-1,3,4-thiadiazol-2-yl]butanamide chemical structure, C15H15N7O3S2, CAS 6190-66-5
2-[(4-Methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[5-(3-nitrophenyl)-1,3,4-thiadiazol-2-yl]butanamide
CAS 6190-66-5C15H15N7O3S2
N-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]butanamide chemical structure, C15H15ClN6OS2, CAS 394237-21-9
N-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]butanamide
CAS 394237-21-9C15H15ClN6OS2
N-[5-(2,5-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide chemical structure, C16H18N6O3S2, CAS 394235-74-6
N-[5-(2,5-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
CAS 394235-74-6C16H18N6O3S2
N-(5-(2-Methoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide chemical structure, C15H16N6O2S2, CAS 394235-48-4
N-(5-(2-Methoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide
CAS 394235-48-4C15H16N6O2S2
N-(5-(4-Bromophenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C13H11BrN6OS2, CAS 394230-11-6
N-(5-(4-Bromophenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 394230-11-6C13H11BrN6OS2
N-(5-(4-Bromophenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide chemical structure, C14H13BrN6OS2, CAS 394234-39-0
N-(5-(4-Bromophenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide
CAS 394234-39-0C14H13BrN6OS2
N-(5-Mesityl-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide chemical structure, C17H20N6OS2, CAS 394235-84-8
N-(5-Mesityl-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide
CAS 394235-84-8C17H20N6OS2
N-(5-(2,4-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide chemical structure, C16H18N6O3S2, CAS 394236-03-4
N-(5-(2,4-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propanamide
CAS 394236-03-4C16H18N6O3S2
N-(5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide chemical structure, C15H15FN6OS2, CAS 394237-58-2
N-(5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide
CAS 394237-58-2C15H15FN6OS2
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl)butanamide chemical structure, C16H18N6OS2, CAS 394237-75-3
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl)butanamide
CAS 394237-75-3C16H18N6OS2
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(m-tolyl)-1,3,4-thiadiazol-2-yl)butanamide chemical structure, C16H18N6OS2, CAS 394237-93-5
2-((4-Methyl-4H-1,2,4-triazol-3-yl)thio)-N-(5-(m-tolyl)-1,3,4-thiadiazol-2-yl)butanamide
CAS 394237-93-5C16H18N6OS2
N-(5-(2-Methoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide chemical structure, C16H18N6O2S2, CAS 394238-30-3
N-(5-(2-Methoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide
CAS 394238-30-3C16H18N6O2S2
N-(5-(4-Methoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide chemical structure, C16H18N6O2S2, CAS 394238-40-5
N-(5-(4-Methoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide
CAS 394238-40-5C16H18N6O2S2
N-(5-(2,5-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide chemical structure, C17H20N6O3S2, CAS 394238-50-7
N-(5-(2,5-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide
CAS 394238-50-7C17H20N6O3S2
N-(5-(2,4-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide chemical structure, C17H20N6O3S2, CAS 394239-02-2
N-(5-(2,4-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)butanamide
CAS 394239-02-2C17H20N6O3S2