Murcko scaffold
Ring system with 3 rings and 23 atoms
42 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 42
- With full pages
- 5
Scaffold SMILES
O=C1CCC(C(=O)NC(Cc2cnc[nH]2)C(=O)N2CCCC2)N1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C1CCC(C(=O)NC(Cc2cnc[nH]2)C(=O)N2CCCC2)N1](/scaffold/GTIOTSFDVQWWRQ-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 42 of 42 chemicals
5-Oxo-L-prolyl-L-histidyl-3,3-dimethyl-L-prolinamide
CAS 76820-40-1C18H26N6O4
Thyrotropin-releasing hormone, gly
CAS 85344-77-0C18H24N6O6
Thyrotropin releasing hormone diazomethyl ketone
CAS 76760-06-0C17H21N7O4
Thyrotropin releasing hormone chloromethyl ketone
CAS 76819-95-9C17H22ClN5O4
Protirelin
CAS 24305-27-9C16H22N6O4
Protirelin tartrate
CAS 53935-32-3C20H28N6O10
Pyroglutamyl-histidyl-proline thioamide
CAS 99933-27-4C16H22N6O3S
Protirelin tartrate monohydrate
CAS 56267-12-0C20H30N6O11
MeTRH
CAS 38983-06-1C17H24N6O4
pGlu-His-Pro-Gly-NH2
CAS 41880-59-5C18H25N7O5
Thyrotropin-releasing hormone, pro-hydrazide-
CAS 60548-59-6C16H23N7O4
Protirelin EP impurity B
CAS 50894-61-6C16H22N6O4
L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-N-(6-aminohexyl)-
CAS 60793-14-8C22H35N7O4
Acid-TRH
CAS 24769-58-2C16H21N5O5
![(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-1-oxo-3-[4-(trifluoromethyl)-1H-imidazol-5-yl]propan-2-yl]-5-oxopyrrolidine-2-carboxamide chemical structure, C17H21F3N6O4, CAS 104987-37-3](/s/BLZCMBVLLZFPFJ-LSJOCFKGSA-N.svg)
(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-1-oxo-3-[4-(trifluoromethyl)-1H-imidazol-5-yl]propan-2-yl]-5-oxopyrrolidine-2-carboxamide
CAS 104987-37-3C17H21F3N6O4
5-Oxo-L-prolyl-L-histidyl-(4R)-4-hydroxy-L-prolinamide
CAS 60548-57-4C16H22N6O5
(S)-N-((R)-1-((S)-2-Carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide
CAS 40600-90-6C16H22N6O4
Pglu-his-pro amide acetate salt
CAS 25575-91-1C18H26N6O6
5-Oxo-L-prolyl-L-histidyl-(3S)-3-ethyl-L-prolinamide
CAS 61406-76-6C18H26N6O4
5-Oxo-L-prolyl-L-histidyl-2-methyl-L-prolinamide
CAS 86825-92-5C17H24N6O4
Thyrotropin-releasing hormone, 2-diazohistidinyl-
CAS 81222-52-8C16H21N8O4+
Thyrotropin releasing hormone 5-fluoroimidazole
CAS 81222-57-3C16H21FN6O4
Thyroliberin acetate salt
CAS 40216-95-3C18H26N6O6
Lauroyl-Pyr-His-Pro-NH2
CAS 131334-69-5C28H44N6O5
- 5-Oxo-L-prolyl-L-histidyl-N-methyl-L-prolinamide27058-69-1C17H24N6O4
- 5-Oxo-L-prolyl-L-histidyl-L-prolyl-L-alaninamide52208-06-7C19H27N7O5
- 5-Oxo-L-prolyl-L-histidyl-N-butyl-L-prolinamide60143-25-1C20H30N6O4
- 5-Oxo-L-prolyl-L-histidyl-N-(10-aminodecyl)-L-prolinamide62146-79-6C26H43N7O4
- 5-Oxo-L-prolyl-L-histidyl-N-(7-aminoheptyl)-L-prolinamide62146-78-5C23H37N7O4
- 5-Oxo-L-prolyl-L-histidyl-N-(4-aminobutyl)-L-prolinamide62146-77-4C20H31N7O4
- 5-Oxo-L-prolyl-N-methyl-L-histidyl-L-prolinamide78430-10-1C17H24N6O4
- 5-Oxo-L-prolyl-1-[(2-methylpropoxy)carbonyl]-L-histidyl-L-prolinamide130817-95-7C21H30N6O6
- Octyl 4-[(2S)-3-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-oxo-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propyl]imidazole-1-carboxylate130817-97-9C25H38N6O6
- 5-Oxo-L-prolyl-1-{[(propan-2-yl)oxy]carbonyl}-L-histidyl-L-prolinamide130817-93-5C20H28N6O6
- 5-Oxo-L-prolyl-1-(butoxycarbonyl)-L-histidyl-L-prolinamide130817-94-6C21H30N6O6
- Hexyl 4-[(2S)-3-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-oxo-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propyl]imidazole-1-carboxylate130817-96-8C23H34N6O6
- 2-Ethylhexyl 4-[(2S)-3-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-oxo-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propyl]imidazole-1-carboxylate130817-98-0C25H38N6O6
- 5-Oxo-L-prolyl-1-(methoxycarbonyl)-L-histidyl-L-prolinamide130817-91-3C18H24N6O6
- 5-Oxo-L-prolyl-1-(ethoxycarbonyl)-L-histidyl-L-prolinamide130817-92-4C19H26N6O6
- H-Pyr-His-Pro-NH2.H-Pyr-His-Pro-NH2.3CH3CO2HC38H56N12O14
- Acetic acid, N-[1-(2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide120876-23-5C38H56N12O14
- H-Pyr-His-Pro-OH.CH3CO2H25575-90-0C18H25N5O7
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C1CCC(C(=O)NC(Cc2cnc[nH]2)C(=O)N2CCCC2)O1](/scaffold/OXKQVROXUGBDMR-UHFFFAOYSA-N/structure.svg)
![Scaffold O=C1CCC(C(=O)NC(Cc2cnc[nH]2)C(=O)N2CCCC2)C1](/scaffold/UCFSJASRSOTVIE-UHFFFAOYSA-N/structure.svg)