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Hormones and steroids

Protirelin

Also known as Thyroliberin, Lopremone, Synthetic TRH

CAS 24305-27-9Formula C16H22N6O4Molar mass 362.39 g/molEC 246-143-4
GHS signal word: Warning. Pictograms: Harmful or irritant 63 suppliers listed Drug substance
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Protirelin chemical structure, C16H22N6O4, CAS 24305-27-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
24305-27-9
Formula
C16H22N6O4
Molar mass
362.39 g/mol
EC number
246-143-4
HS code
293329
Category
Hormones and steroids

What is Protirelin?

Plain description, key identifiers and synonyms

Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide.

Protirelin is a hormone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CAS number
24305-27-9 CAS number cross-checkedOther or deprecated CAS: 117217-40-0
EC number
246-143-4
Molecular formula
C16H22N6O4
UNII
5Y5F15120W
MDL number
MFCD00038640
INCI name
PYROGLUTAMYL DIPEPTIDE-30 AMIDE
InChIKey
XNSAINXGIQZQOO-SRVKXCTJSA-N
InChI
InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
Canonical SMILES
NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1
Isomeric SMILES
C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C(=O)N

Synonyms

  • Thyroliberin
  • Lopremone
  • Synthetic TRH
  • Rifathyroin
  • Thypinone
  • Thyrotropin-releasing factor
  • TSH-releasing factor
  • Protireline
  • Thyrotropic-releasing factor
  • 5-Oxo-L-prolyl-L-histidyl-L-prolinamide
  • Protirelinum
  • Thyrel trh
  • Synthetic tsh-releasing factor
  • Relefact TRH
  • Abbott 38579
  • Protirelin, synthetic
  • Protirelina
  • 5-oxo-pro-his-pro-nh2
  • L-Pyroglutamyl-L-histidyl-L-prolineamide
  • FDA 1725
  • L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-
  • (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
  • Ro 8-6270/9
  • Relefact TRH (TN)
  • L-Pyroglutamyl-L-histidinyl-L-prolinamide
Show all 26 synonyms
  • Protireline (INN-French)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
362.39 g/molcalc.
Exact mass
362.1703 Dacalc.
LogP (octanol/water)
-1.81calc.
Topological polar surface area
150.3 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
26calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCC(C(=O)NC(Cc2cnc[nH]2)C(=O)N2CCCC2)N1

O=C1CCC(C(=O)NC(Cc2cnc[nH]2)C(=O)N2CCCC2)N1

3 rings, 23 atoms.

41 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H332Harmful if inhaled.
Precautionary statements (4)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P271Use only outdoors or in a well-ventilated area.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Protirelin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 63 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

63 suppliers in 12 countries

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Protirelin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name PYROGLUTAMYL DIPEPTIDE-30 AMIDE(skin conditioning)

Pharmacological actions

  • Hormones

Roles

  • animal metabolite
  • antineoplastic agent
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • pharmaceutical

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Protirelin is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Protirelin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Protirelin, based on the data on this page

What is Protirelin?

Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide.

What is the CAS number of Protirelin?

The CAS registry number of Protirelin is 24305-27-9. Other or deprecated CAS numbers: 117217-40-0.

What is the molecular formula and weight of Protirelin?

The molecular formula of Protirelin is C16H22N6O4 and its molar mass is 362.39 g/mol.

What is Protirelin used for?

Known uses and roles of Protirelin include hormones and steroids in pharmaceuticals, skin conditioning agents in cosmetics and personal care, animal metabolite, antineoplastic agent, eukaryotic metabolite and 7 more.

Is Protirelin hazardous?

Protirelin carries the GHS signal word "Warning". Main hazards: harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Protirelin?

Protirelin is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Protirelin?

CompoundList lists 63 suppliers of Protirelin in United States, China, Germany, Spain and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Protirelin?

Suppliers quote Protirelin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Protirelin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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