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Murcko scaffold

1H,2H,3H,4H-Pyrido(2,3-b)pyrazin-2-one scaffold

62 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
62
With full pages
10
Scaffold SMILES

O=C1CNc2ncccc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1H,2H,3H,4H-Pyrido(2,3-b)pyrazin-2-one page
Murcko scaffold O=C1CNc2ncccc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

3-Methyl-1H,2H,3H,4H-pyrido(2,3-b)pyrazin-2-one chemical structure, C8H9N3O, CAS 74983-04-3
3-Methyl-1H,2H,3H,4H-pyrido(2,3-b)pyrazin-2-one
CAS 74983-04-3C8H9N3O
1H,2H,3H,4H-Pyrido(2,3-b)pyrazin-2-one chemical structure, C7H7N3O, CAS 67074-78-6
1H,2H,3H,4H-Pyrido(2,3-b)pyrazin-2-one
CAS 67074-78-6C7H7N3O
3,6-Dimethyl-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one chemical structure, C9H11N3O, CAS 159104-35-5
3,6-Dimethyl-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one
CAS 159104-35-5C9H11N3O
(3R)-6-Chloro-3-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one chemical structure, C8H8ClN3O, CAS 2378642-87-4
(3R)-6-Chloro-3-methyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one
CAS 2378642-87-4C8H8ClN3O
6,8-Dimethyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one chemical structure, C9H11N3O, CAS 889943-33-3
6,8-Dimethyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
CAS 889943-33-3C9H11N3O
7-Iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one chemical structure, C7H6IN3O, CAS 957193-64-5
7-Iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one
CAS 957193-64-5C7H6IN3O
3-Ethyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one chemical structure, C9H11N3O, CAS 1315365-27-5
3-Ethyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
CAS 1315365-27-5C9H11N3O
3-(Propan-2-yl)-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one chemical structure, C10H13N3O, CAS 1315365-08-2
3-(Propan-2-yl)-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
CAS 1315365-08-2C10H13N3O
6-Chloro-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one chemical structure, C7H6ClN3O, CAS 1314953-23-5
6-Chloro-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one
CAS 1314953-23-5C7H6ClN3O
6-Methoxy-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one chemical structure, C8H9N3O2, CAS 951160-15-9
6-Methoxy-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one
CAS 951160-15-9C8H9N3O2
4-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one chemical structure, C8H9N3O, CAS 1314974-86-1
4-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
CAS 1314974-86-1C8H9N3O
6-Chloro-4-methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one chemical structure, C8H8ClN3O, CAS 1314953-62-2
6-Chloro-4-methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
CAS 1314953-62-2C8H8ClN3O
7-Fluoro-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one chemical structure, C7H6FN3O, CAS 1314968-89-2
7-Fluoro-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one
CAS 1314968-89-2C7H6FN3O
8-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one chemical structure, C8H9N3O, CAS 1314934-34-3
8-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
CAS 1314934-34-3C8H9N3O
6-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one chemical structure, C8H9N3O, CAS 1314976-52-7
6-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
CAS 1314976-52-7C8H9N3O
7-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one chemical structure, C8H9N3O, CAS 1314968-98-3
7-Methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
CAS 1314968-98-3C8H9N3O
7-Chloro-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one chemical structure, C7H6ClN3O, CAS 1314912-26-9
7-Chloro-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one
CAS 1314912-26-9C7H6ClN3O
7-Iodo-3,3-dimethyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one chemical structure, C9H10IN3O, CAS 957194-64-8
7-Iodo-3,3-dimethyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
CAS 957194-64-8C9H10IN3O
1-Methyl-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one chemical structure, C8H9N3O, CAS 67074-79-7
1-Methyl-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one
CAS 67074-79-7C8H9N3O
tert-Butyl 7-bromo-2-oxo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-4-carboxylate chemical structure, C12H14BrN3O3, CAS 709652-85-7
tert-Butyl 7-bromo-2-oxo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-4-carboxylate
CAS 709652-85-7C12H14BrN3O3
7-Bromo-1H,2H,3H,4H-pyrido(2,3-b)pyrazin-2-one chemical structure, C7H6BrN3O, CAS 709652-84-6
7-Bromo-1H,2H,3H,4H-pyrido(2,3-b)pyrazin-2-one
CAS 709652-84-6C7H6BrN3O
4-Methyl-2-oxo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-7-carboxylic acid chemical structure, C9H9N3O3, CAS 1500976-77-1
4-Methyl-2-oxo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-7-carboxylic acid
CAS 1500976-77-1C9H9N3O3
2-Oxo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-7-carboxylic acid chemical structure, C8H7N3O3, CAS 2648957-25-7
2-Oxo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-7-carboxylic acid
CAS 2648957-25-7C8H7N3O3
7-Bromo-3-methyl-1H,2H,3H,4H-pyrido(2,3-b)pyrazin-2-one chemical structure, C8H8BrN3O, CAS 1541874-12-7
7-Bromo-3-methyl-1H,2H,3H,4H-pyrido(2,3-b)pyrazin-2-one
CAS 1541874-12-7C8H8BrN3O