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Murcko scaffold

Dioxene scaffold

41 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
6
Chemicals
41
With full pages
6
Scaffold SMILES

C1=COCCO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.

Substructure search with this scaffoldOpen the Dioxene page
Murcko scaffold C1=COCCO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

2,3-Dihydro-5,6-dimethyl-1,4-dioxin chemical structure, C6H10O2, CAS 25465-18-3
2,3-Dihydro-5,6-dimethyl-1,4-dioxin
CAS 25465-18-3C6H10O2
Dioxene chemical structure, C4H6O2, CAS 543-75-9
Dioxene
CAS 543-75-9C4H6O2
Phosphorodithioic acid, O,O-diethyl S-(5,6-dihydro-1,4-dioxin-2-yl) ester chemical structure, C8H15O4PS2, CAS 16270-87-4
Phosphorodithioic acid, O,O-diethyl S-(5,6-dihydro-1,4-dioxin-2-yl) ester
CAS 16270-87-4C8H15O4PS2
5-Methyl-2,3-dihydro-1,4-dioxine chemical structure, C5H8O2, CAS 3973-22-6
5-Methyl-2,3-dihydro-1,4-dioxine
CAS 3973-22-6C5H8O2
5,6-Dihydro-[1,4]dioxine-2-carboxylic acid chemical structure, C5H6O4, CAS 61564-98-5
5,6-Dihydro-[1,4]dioxine-2-carboxylic acid
CAS 61564-98-5C5H6O4
5,6-Dihydro-1,4-dioxine-2-carbaldehyde chemical structure, C5H6O3, CAS 59518-69-3
5,6-Dihydro-1,4-dioxine-2-carbaldehyde
CAS 59518-69-3C5H6O3
Ethyl 5,6-dihydro-2-trifluoromethyl-1,4-dioxin-3-carboxylate chemical structure, C8H9F3O4, CAS 310460-99-2
Ethyl 5,6-dihydro-2-trifluoromethyl-1,4-dioxin-3-carboxylate
CAS 310460-99-2C8H9F3O4
5,6-Dihydro-2-trifluoromethyl-1,4-dioxin-3-carboxylic acid chemical structure, C6H5F3O4, CAS 310461-01-9
5,6-Dihydro-2-trifluoromethyl-1,4-dioxin-3-carboxylic acid
CAS 310461-01-9C6H5F3O4
1,4-Dioxin-2-carbonitrile, 5,6-dihydro-3-(1,2-propadienyl)-(9CI) chemical structure, C8H7NO2, CAS 175288-90-1
1,4-Dioxin-2-carbonitrile, 5,6-dihydro-3-(1,2-propadienyl)-(9CI)
CAS 175288-90-1C8H7NO2
Tributyl(5,6-dihydro-1,4-dioxin-2-yl)stannane chemical structure, C16H32O2Sn, CAS 131470-66-1
Tributyl(5,6-dihydro-1,4-dioxin-2-yl)stannane
CAS 131470-66-1C16H32O2Sn
1,4-Dioxin, 2,3-dihydro-2,3-dimethoxy-2,3,5-trimethyl-, (2S,3S)- chemical structure, C9H16O4, CAS 835640-77-2
1,4-Dioxin, 2,3-dihydro-2,3-dimethoxy-2,3,5-trimethyl-, (2S,3S)-
CAS 835640-77-2C9H16O4
5,6-Dihydro-1,4-dioxine-2-carbonitrile chemical structure, C5H5NO2, CAS 59602-13-0
5,6-Dihydro-1,4-dioxine-2-carbonitrile
CAS 59602-13-0C5H5NO2
1-(5,6-Dihydro-1,4-dioxin-2-yl)ethan-1-one chemical structure, C6H8O3, CAS 59602-14-1
1-(5,6-Dihydro-1,4-dioxin-2-yl)ethan-1-one
CAS 59602-14-1C6H8O3
5,6-Dihydro-1,4-dioxine-2-carbonyl chloride chemical structure, C5H5ClO3, CAS 61564-99-6
5,6-Dihydro-1,4-dioxine-2-carbonyl chloride
CAS 61564-99-6C5H5ClO3
Ethyl (5,6-dihydro-1,4-dioxin-2-yl)acetate chemical structure, C8H12O4, CAS 60170-69-6
Ethyl (5,6-dihydro-1,4-dioxin-2-yl)acetate
CAS 60170-69-6C8H12O4
5-Chloro-2,3-dihydro-1,4-dioxine chemical structure, C4H5ClO2, CAS 57253-40-4
5-Chloro-2,3-dihydro-1,4-dioxine
CAS 57253-40-4C4H5ClO2
2-Bromo-1,4-dioxene chemical structure, C4H5BrO2, CAS 74671-59-3
2-Bromo-1,4-dioxene
CAS 74671-59-3C4H5BrO2
5,6-Dihydro-1,4-dioxin-2-ylphosphonic dichloride chemical structure, C4H5Cl2O3P, CAS 78396-85-7
5,6-Dihydro-1,4-dioxin-2-ylphosphonic dichloride
CAS 78396-85-7C4H5Cl2O3P
Lithium 5,6-dihydro-1,4-dioxin-2-ide chemical structure, C4H5LiO2, CAS 83726-22-1
Lithium 5,6-dihydro-1,4-dioxin-2-ide
CAS 83726-22-1C4H5LiO2
[5-(Chloromethyl)-5,6-dihydro-1,4-dioxin-2-yl]phosphonic dichloride chemical structure, C5H6Cl3O3P, CAS 88788-34-5
[5-(Chloromethyl)-5,6-dihydro-1,4-dioxin-2-yl]phosphonic dichloride
CAS 88788-34-5C5H6Cl3O3P
Diethyl (3-methyl-5,6-dihydro-1,4-dioxin-2-yl)phosphonate chemical structure, C9H17O5P, CAS 95879-59-7
Diethyl (3-methyl-5,6-dihydro-1,4-dioxin-2-yl)phosphonate
CAS 95879-59-7C9H17O5P
Diethyl 5,6-dihydro-1,4-dioxin-2-ylphosphonate chemical structure, C8H15O5P, CAS 66567-86-0
Diethyl 5,6-dihydro-1,4-dioxin-2-ylphosphonate
CAS 66567-86-0C8H15O5P
1-(5,6-Dihydro-1,4-dioxin-2-yl)-3-methylbutan-1-one chemical structure, C9H14O3, CAS 131470-68-3
1-(5,6-Dihydro-1,4-dioxin-2-yl)-3-methylbutan-1-one
CAS 131470-68-3C9H14O3
2,2,3,3,5,6-Hexafluoro-2,3-dihydro-1,4-dioxine chemical structure, C4F6O2, CAS 56625-38-8
2,2,3,3,5,6-Hexafluoro-2,3-dihydro-1,4-dioxine
CAS 56625-38-8C4F6O2