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Murcko scaffold

Ring system with 4 rings and 21 atoms

80 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
80
With full pages
28
Scaffold SMILES

C(=C1CCCc2cc3ccccc3nc21)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=C1CCCc2cc3ccccc3nc21)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 80 chemicals

4-{[4-(Dimethylamino)phenyl]methylidene}-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C24H24N2O2
4-{[4-(Dimethylamino)phenyl]methylidene}-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid
C24H24N2O2
(E)-2-Methyl-4-((perfluorophenyl)methylene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C22H14F5NO2, CAS 745793-15-1
(E)-2-Methyl-4-((perfluorophenyl)methylene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 745793-15-1C22H14F5NO2
4-[(4-tert-Butylphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C25H25NO2
4-[(4-tert-Butylphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C25H25NO2
2-tert-Butyl-4-[(4-chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C25H24ClNO2
2-tert-Butyl-4-[(4-chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid
C25H24ClNO2
4-[(4-Fluorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C21H16FNO2
4-[(4-Fluorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C21H16FNO2
2-tert-Butyl-4-[(3-chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C25H24ClNO2
2-tert-Butyl-4-[(3-chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C25H24ClNO2
4-[(4-Hydroxyphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C21H17NO3
4-[(4-Hydroxyphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C21H17NO3
4-[(2,3-Dimethoxyphenyl)methylidene]-2-methyl-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C24H23NO4
4-[(2,3-Dimethoxyphenyl)methylidene]-2-methyl-2,3-dihydro-1H-acridine-9-carboxylic acid
C24H23NO4
4-(4-Diethylamino-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid chemical structure, C25H26N2O2
4-(4-Diethylamino-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid
C25H26N2O2
2-tert-Butyl-4-[(3,4,5-trimethoxyphenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C28H31NO5
2-tert-Butyl-4-[(3,4,5-trimethoxyphenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid
C28H31NO5
4-{[4-(Diethylamino)phenyl]methylidene}-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C26H28N2O2
4-{[4-(Diethylamino)phenyl]methylidene}-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid
C26H28N2O2
4-[(2-Chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C21H16ClNO2
4-[(2-Chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid
C21H16ClNO2
4-Benzylidene-2-methyl-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C22H19NO2
4-Benzylidene-2-methyl-2,3-dihydro-1H-acridine-9-carboxylic acid
C22H19NO2
(Z)-2-Methyl-4-(4-(trifluoromethyl)benzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C23H18F3NO2, CAS 561028-62-4
(Z)-2-Methyl-4-(4-(trifluoromethyl)benzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 561028-62-4C23H18F3NO2
(Z)-4-(3-Fluorobenzylidene)-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C22H18FNO2, CAS 556041-58-8
(Z)-4-(3-Fluorobenzylidene)-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 556041-58-8C22H18FNO2
(Z)-4-(4-(Trifluoromethyl)benzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C22H16F3NO2, CAS 571929-34-5
(Z)-4-(4-(Trifluoromethyl)benzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 571929-34-5C22H16F3NO2
4-[(2,6-Difluorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C21H15F2NO2
4-[(2,6-Difluorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C21H15F2NO2
(Z)-4-(4-Isopropylbenzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C24H23NO2, CAS 345988-06-9
(Z)-4-(4-Isopropylbenzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 345988-06-9C24H23NO2
4-[(3,4-Dimethoxyphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C23H21NO4
4-[(3,4-Dimethoxyphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C23H21NO4
4-Benzylidene-1,2,3,4-tetrahydro-acridine-9-carboxylic acid chemical structure, C21H17NO2
4-Benzylidene-1,2,3,4-tetrahydro-acridine-9-carboxylic acid
C21H17NO2
4-(4-Dimethylamino-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid chemical structure, C23H22N2O2
4-(4-Dimethylamino-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid
C23H22N2O2
4-[(4-Methoxyphenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C22H19NO3
4-[(4-Methoxyphenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid
C22H19NO3
4-[(4-Chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C21H16ClNO2
4-[(4-Chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C21H16ClNO2
4-[(2,3-Dichlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C21H15Cl2NO2
4-[(2,3-Dichlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid
C21H15Cl2NO2