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Murcko scaffold

Ring system with 4 rings and 21 atoms

80 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
80
With full pages
28
Scaffold SMILES

C(=C1CCCc2cc3ccccc3nc21)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=C1CCCc2cc3ccccc3nc21)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 80 of 80 chemicals

4-(4-Methoxybenzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C22H19NO3, CAS 380342-08-5
4-(4-Methoxybenzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 380342-08-5C22H19NO3
(4E)-4-[(4-Chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C21H16ClNO2
(4E)-4-[(4-Chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C21H16ClNO2
(4E)-4-[(2,3-Dichlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C21H15Cl2NO2
(4E)-4-[(2,3-Dichlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C21H15Cl2NO2
4-(3-Nitro-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid chemical structure, C21H16N2O4, CAS 379255-82-0
4-(3-Nitro-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid
CAS 379255-82-0C21H16N2O4
2-tert-Butyl-4-((4-methoxyphenyl)methylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C26H27NO3, CAS 380573-76-2
2-tert-Butyl-4-((4-methoxyphenyl)methylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 380573-76-2C26H27NO3
4-[(2-Chloro-6-fluorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C21H15ClFNO2, CAS 565167-98-8
4-[(2-Chloro-6-fluorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 565167-98-8C21H15ClFNO2
4-(4-tert-Butyl-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid chemical structure, C25H25NO2
4-(4-tert-Butyl-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid
C25H25NO2
(4E)-4-[[4-(Diethylamino)phenyl]methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C25H26N2O2
(4E)-4-[[4-(Diethylamino)phenyl]methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C25H26N2O2
4-(4-Diethylamino-benzylidene)-2-methyl-1,2,3,4-tetrahydro-acridine-9-carboxylic acid chemical structure, C26H28N2O2
4-(4-Diethylamino-benzylidene)-2-methyl-1,2,3,4-tetrahydro-acridine-9-carboxylic acid
C26H28N2O2
(4E)-4-[(2-Chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C21H16ClNO2
(4E)-4-[(2-Chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
C21H16ClNO2
4-[(3,4-Dimethoxyphenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C23H21NO4, CAS 379726-66-6
4-[(3,4-Dimethoxyphenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 379726-66-6C23H21NO4
(4E)-4-Benzylidene-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C21H17NO2
(4E)-4-Benzylidene-2,3-dihydro-1H-acridine-9-carboxylic acid
C21H17NO2
4-{[4-(Dimethylamino)phenyl]methylidene}-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C23H22N2O2
4-{[4-(Dimethylamino)phenyl]methylidene}-1,2,3,4-tetrahydroacridine-9-carboxylic acid
C23H22N2O2
4-(4-Methoxy-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid chemical structure, C22H19NO3
4-(4-Methoxy-benzylidene)-1,2,3,4-tetrahydro-acridine-9-carboxylic acid
C22H19NO3
2-Amino-2-oxoethyl (4E)-1,2,3,4-tetrahydro-4-[(4-nitrophenyl)methylene]-9-acridinecarboxylate chemical structure, C23H19N3O5, CAS 1001756-22-4
2-Amino-2-oxoethyl (4E)-1,2,3,4-tetrahydro-4-[(4-nitrophenyl)methylene]-9-acridinecarboxylate
CAS 1001756-22-4C23H19N3O5
4-(2,3-Dimethoxy-benzylidene)-2-methyl-1,2,3,4-tetrahydro-acridine-9-carboxylic acid chemical structure, C24H23NO4
4-(2,3-Dimethoxy-benzylidene)-2-methyl-1,2,3,4-tetrahydro-acridine-9-carboxylic acid
C24H23NO4
4-(2,3-Dichlorobenzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C21H15Cl2NO2, CAS 379728-20-8
4-(2,3-Dichlorobenzylidene)-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 379728-20-8C21H15Cl2NO2
(4Z)-2-tert-Butyl-4-[(4-chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C25H24ClNO2, CAS 380437-35-4
(4Z)-2-tert-Butyl-4-[(4-chlorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
CAS 380437-35-4C25H24ClNO2
(4Z)-2-tert-Butyl-4-[(3,4,5-trimethoxyphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C28H31NO5, CAS 519150-66-4
(4Z)-2-tert-Butyl-4-[(3,4,5-trimethoxyphenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
CAS 519150-66-4C28H31NO5
4-[(4-Nitrophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C21H16N2O4, CAS 379728-19-5
4-[(4-Nitrophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 379728-19-5C21H16N2O4
4-[(4-Chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C21H16ClNO2, CAS 379728-21-9
4-[(4-Chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 379728-21-9C21H16ClNO2
(4Z)-4-[(4-Fluorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid chemical structure, C21H16FNO2, CAS 380437-34-3
(4Z)-4-[(4-Fluorophenyl)methylidene]-2,3-dihydro-1H-acridine-9-carboxylic acid
CAS 380437-34-3C21H16FNO2
4-Benzylidene-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C22H19NO2, CAS 721413-92-9
4-Benzylidene-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 721413-92-9C22H19NO2
4-[(4-Methoxyphenyl)methylidene]-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid chemical structure, C23H21NO3, CAS 721413-88-3
4-[(4-Methoxyphenyl)methylidene]-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid
CAS 721413-88-3C23H21NO3