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Murcko scaffold

Ring system with 4 rings and 29 atoms

196 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
196
With full pages
14
Scaffold SMILES

O=C(Cn1c(=O)c(CNc2ccccc2)cc2ccccc21)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1c(=O)c(CNc2ccccc2)cc2ccccc21)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 196 chemicals

2-(6,7-Dimethoxy-2-oxo-3-((phenylamino)methyl)quinolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C27H27N3O5, CAS 894549-92-9
2-(6,7-Dimethoxy-2-oxo-3-((phenylamino)methyl)quinolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide
CAS 894549-92-9C27H27N3O5
N-(3-Chloro-4-methylphenyl)-2-{6,7-dimethoxy-2-oxo-3-[(phenylamino)methyl]-1,2-dihydroquinolin-1-yl}acetamide chemical structure, C27H26ClN3O4, CAS 894550-40-4
N-(3-Chloro-4-methylphenyl)-2-{6,7-dimethoxy-2-oxo-3-[(phenylamino)methyl]-1,2-dihydroquinolin-1-yl}acetamide
CAS 894550-40-4C27H26ClN3O4
2-{6,7-Dimethoxy-2-oxo-3-[(phenylamino)methyl]-1,2-dihydroquinolin-1-yl}-N-(3,5-dimethylphenyl)acetamide chemical structure, C28H29N3O4, CAS 894550-87-9
2-{6,7-Dimethoxy-2-oxo-3-[(phenylamino)methyl]-1,2-dihydroquinolin-1-yl}-N-(3,5-dimethylphenyl)acetamide
CAS 894550-87-9C28H29N3O4
N-(3-Chloro-2-methylphenyl)-2-{6,7-dimethoxy-2-oxo-3-[(phenylamino)methyl]-1,2-dihydroquinolin-1-yl}acetamide chemical structure, C27H26ClN3O4, CAS 894551-03-2
N-(3-Chloro-2-methylphenyl)-2-{6,7-dimethoxy-2-oxo-3-[(phenylamino)methyl]-1,2-dihydroquinolin-1-yl}acetamide
CAS 894551-03-2C27H26ClN3O4
N-(2,4-Difluorophenyl)-2-(6,7-dimethoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)acetamide chemical structure, C27H25F2N3O4, CAS 894552-86-4
N-(2,4-Difluorophenyl)-2-(6,7-dimethoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)acetamide
CAS 894552-86-4C27H25F2N3O4
2-(7-Methoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)-N-(3-(trifluoromethyl)phenyl)acetamide chemical structure, C27H24F3N3O3, CAS 893788-21-1
2-(7-Methoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)-N-(3-(trifluoromethyl)phenyl)acetamide
CAS 893788-21-1C27H24F3N3O3
N-(3-Chloro-4-methoxyphenyl)-2-(7-methoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)acetamide chemical structure, C27H26ClN3O4, CAS 893788-86-8
N-(3-Chloro-4-methoxyphenyl)-2-(7-methoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)acetamide
CAS 893788-86-8C27H26ClN3O4
N-(2-Chloro-4-methylphenyl)-2-(7-methoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)acetamide chemical structure, C27H26ClN3O3, CAS 893787-09-2
N-(2-Chloro-4-methylphenyl)-2-(7-methoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)acetamide
CAS 893787-09-2C27H26ClN3O3
N-(3-Chloro-2-methylphenyl)-2-(7-methoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)acetamide chemical structure, C27H26ClN3O3, CAS 893788-88-0
N-(3-Chloro-2-methylphenyl)-2-(7-methoxy-2-oxo-3-((p-tolylamino)methyl)quinolin-1(2H)-yl)acetamide
CAS 893788-88-0C27H26ClN3O3
2-(3-(((4-Ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(4-isopropylphenyl)acetamide chemical structure, C30H33N3O3, CAS 893784-97-9
2-(3-(((4-Ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(4-isopropylphenyl)acetamide
CAS 893784-97-9C30H33N3O3
2-(3-(((4-Ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(o-tolyl)acetamide chemical structure, C28H29N3O3, CAS 893785-01-8
2-(3-(((4-Ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(o-tolyl)acetamide
CAS 893785-01-8C28H29N3O3
N-(2,5-Dimethylphenyl)-2-(3-(((4-ethylphenyl)amino)methyl)-6,7-dimethoxy-2-oxoquinolin-1(2H)-yl)acetamide chemical structure, C30H33N3O4, CAS 893789-07-6
N-(2,5-Dimethylphenyl)-2-(3-(((4-ethylphenyl)amino)methyl)-6,7-dimethoxy-2-oxoquinolin-1(2H)-yl)acetamide
CAS 893789-07-6C30H33N3O4
2-(3-(((4-Ethylphenyl)amino)methyl)-6,7-dimethoxy-2-oxoquinolin-1(2H)-yl)-N-(4-fluorophenyl)acetamide chemical structure, C28H28FN3O4, CAS 894557-03-0
2-(3-(((4-Ethylphenyl)amino)methyl)-6,7-dimethoxy-2-oxoquinolin-1(2H)-yl)-N-(4-fluorophenyl)acetamide
CAS 894557-03-0C28H28FN3O4
N-(2,4-Difluorophenyl)-2-(3-(((4-ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)acetamide chemical structure, C27H25F2N3O3, CAS 893785-09-6
N-(2,4-Difluorophenyl)-2-(3-(((4-ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)acetamide
CAS 893785-09-6C27H25F2N3O3
2-(3-(((4-Ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C28H29N3O4, CAS 894558-66-8
2-(3-(((4-Ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide
CAS 894558-66-8C28H29N3O4
N-(3-Chloro-4-methylphenyl)-2-(3-(((4-ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)acetamide chemical structure, C28H28ClN3O3, CAS 894558-81-7
N-(3-Chloro-4-methylphenyl)-2-(3-(((4-ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)acetamide
CAS 894558-81-7C28H28ClN3O3
N-(3-Chloro-2-methylphenyl)-2-(3-(((4-ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)acetamide chemical structure, C28H28ClN3O3, CAS 893785-94-9
N-(3-Chloro-2-methylphenyl)-2-(3-(((4-ethylphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)acetamide
CAS 893785-94-9C28H28ClN3O3
N-(3,4-Dimethylphenyl)-2-(7-methoxy-3-(((4-methoxyphenyl)amino)methyl)-2-oxoquinolin-1(2H)-yl)acetamide chemical structure, C28H29N3O4, CAS 894559-98-9
N-(3,4-Dimethylphenyl)-2-(7-methoxy-3-(((4-methoxyphenyl)amino)methyl)-2-oxoquinolin-1(2H)-yl)acetamide
CAS 894559-98-9C28H29N3O4
2-(7-Methoxy-3-(((4-methoxyphenyl)amino)methyl)-2-oxoquinolin-1(2H)-yl)-N-(3-methoxyphenyl)acetamide chemical structure, C27H27N3O5, CAS 894562-09-5
2-(7-Methoxy-3-(((4-methoxyphenyl)amino)methyl)-2-oxoquinolin-1(2H)-yl)-N-(3-methoxyphenyl)acetamide
CAS 894562-09-5C27H27N3O5
N-(4-Ethoxyphenyl)-2-(7-methoxy-3-(((4-methoxyphenyl)amino)methyl)-2-oxoquinolin-1(2H)-yl)acetamide chemical structure, C28H29N3O5, CAS 894562-25-5
N-(4-Ethoxyphenyl)-2-(7-methoxy-3-(((4-methoxyphenyl)amino)methyl)-2-oxoquinolin-1(2H)-yl)acetamide
CAS 894562-25-5C28H29N3O5
N-(5-Chloro-2-methylphenyl)-2-(7-methoxy-3-(((4-methoxyphenyl)amino)methyl)-2-oxoquinolin-1(2H)-yl)acetamide chemical structure, C27H26ClN3O4, CAS 893788-72-2
N-(5-Chloro-2-methylphenyl)-2-(7-methoxy-3-(((4-methoxyphenyl)amino)methyl)-2-oxoquinolin-1(2H)-yl)acetamide
CAS 893788-72-2C27H26ClN3O4
2-(3-(((3,4-Dimethoxyphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(p-tolyl)acetamide chemical structure, C28H29N3O5, CAS 894562-95-9
2-(3-(((3,4-Dimethoxyphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(p-tolyl)acetamide
CAS 894562-95-9C28H29N3O5
2-(3-(((3,4-Dimethoxyphenyl)amino)methyl)-6-methoxy-2-oxoquinolin-1(2H)-yl)-N-(o-tolyl)acetamide chemical structure, C28H29N3O5, CAS 894563-03-2
2-(3-(((3,4-Dimethoxyphenyl)amino)methyl)-6-methoxy-2-oxoquinolin-1(2H)-yl)-N-(o-tolyl)acetamide
CAS 894563-03-2C28H29N3O5
2-(3-(((3,4-Dimethoxyphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(2-fluorophenyl)acetamide chemical structure, C27H26FN3O5, CAS 894563-43-0
2-(3-(((3,4-Dimethoxyphenyl)amino)methyl)-7-methoxy-2-oxoquinolin-1(2H)-yl)-N-(2-fluorophenyl)acetamide
CAS 894563-43-0C27H26FN3O5