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Murcko scaffold

Ring system with 3 rings and 24 atoms

47 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
47
With full pages
1
Scaffold SMILES

O=C1NC(=S)SC1=Cc1ccc(OCCOc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=S)SC1=Cc1ccc(OCCOc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

(5E)-3-Methyl-5-[[4-[2-(2-methylphenoxy)ethoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H19NO3S2, CAS 299905-64-9
(5E)-3-Methyl-5-[[4-[2-(2-methylphenoxy)ethoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299905-64-9C20H19NO3S2
(5Z)-5-[[3-Chloro-4-[2-(3,5-dimethylphenoxy)ethoxy]-5-ethoxyphenyl]methylidene]-3-ethyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C24H26ClNO4S2, CAS 429641-62-3
(5Z)-5-[[3-Chloro-4-[2-(3,5-dimethylphenoxy)ethoxy]-5-ethoxyphenyl]methylidene]-3-ethyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429641-62-3C24H26ClNO4S2
(5Z)-5-[[3-Chloro-5-ethoxy-4-[2-(4-methoxyphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C22H22ClNO5S2, CAS 429638-53-9
(5Z)-5-[[3-Chloro-5-ethoxy-4-[2-(4-methoxyphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429638-53-9C22H22ClNO5S2
(5Z)-5-[[3-Chloro-4-[2-(4-chloro-3-methylphenoxy)ethoxy]-5-ethoxyphenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C22H21Cl2NO4S2, CAS 429643-96-9
(5Z)-5-[[3-Chloro-4-[2-(4-chloro-3-methylphenoxy)ethoxy]-5-ethoxyphenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429643-96-9C22H21Cl2NO4S2
(5Z)-5-[[3-Bromo-5-methoxy-4-[2-(4-methoxyphenoxy)ethoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H18BrNO5S2, CAS 428859-99-8
(5Z)-5-[[3-Bromo-5-methoxy-4-[2-(4-methoxyphenoxy)ethoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 428859-99-8C20H18BrNO5S2
(5E)-5-[[4-[2-(3,4-Dimethylphenoxy)ethoxy]-3-ethoxyphenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C23H25NO4S2, CAS 299911-27-6
(5E)-5-[[4-[2-(3,4-Dimethylphenoxy)ethoxy]-3-ethoxyphenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299911-27-6C23H25NO4S2
(5E)-5-[[3-Bromo-5-ethoxy-4-[2-(3-methylphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C22H22BrNO4S2, CAS 300365-94-0
(5E)-5-[[3-Bromo-5-ethoxy-4-[2-(3-methylphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 300365-94-0C22H22BrNO4S2
(5E)-3-Methyl-5-[[4-[2-(4-nitrophenoxy)ethoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C19H16N2O5S2, CAS 299908-30-8
(5E)-3-Methyl-5-[[4-[2-(4-nitrophenoxy)ethoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299908-30-8C19H16N2O5S2
(5E)-5-[[3,5-Dichloro-4-[2-(2-methoxyphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H17Cl2NO4S2, CAS 299961-04-9
(5E)-5-[[3,5-Dichloro-4-[2-(2-methoxyphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299961-04-9C20H17Cl2NO4S2
Ambcb6174012 chemical structure, C22H23NO5S2, CAS 6174-01-2
Ambcb6174012
CAS 6174-01-2C22H23NO5S2
(5E)-5-[[3-Iodo-5-methoxy-4-[2-(2-methoxyphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H20INO5S2, CAS 300846-12-2
(5E)-5-[[3-Iodo-5-methoxy-4-[2-(2-methoxyphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 300846-12-2C21H20INO5S2
(5E)-3-Methyl-5-[[4-[2-(3-methylphenoxy)ethoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H19NO3S2, CAS 299905-63-8
(5E)-3-Methyl-5-[[4-[2-(3-methylphenoxy)ethoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299905-63-8C20H19NO3S2
(5E)-5-[[3-Chloro-5-methoxy-4-[2-(4-methylphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H20ClNO4S2, CAS 299957-50-9
(5E)-5-[[3-Chloro-5-methoxy-4-[2-(4-methylphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299957-50-9C21H20ClNO4S2
(5E)-5-({3-Chloro-5-ethoxy-4-[2-(2-methylphenoxy)ethoxy]phenyl}methylidene)-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C22H22ClNO4S2, CAS 6184-77-6
(5E)-5-({3-Chloro-5-ethoxy-4-[2-(2-methylphenoxy)ethoxy]phenyl}methylidene)-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 6184-77-6C22H22ClNO4S2
(5E)-5-[[4-[2-(2-Methoxyphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H19NO4S2, CAS 299906-44-8
(5E)-5-[[4-[2-(2-Methoxyphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299906-44-8C20H19NO4S2
5-{4-[2-(4-Bromophenoxy)ethoxy]-3-chloro-5-ethoxybenzylidene}-3-methyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H19BrClNO4S2, CAS 6187-76-4
5-{4-[2-(4-Bromophenoxy)ethoxy]-3-chloro-5-ethoxybenzylidene}-3-methyl-2-thioxo-1,3-thiazolidin-4-one
CAS 6187-76-4C21H19BrClNO4S2
(5E)-5-(3-Iodo-5-methoxy-4-{2-[2-(prop-2-en-1-yl)phenoxy]ethoxy}benzylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C23H22INO4S2, CAS 6188-74-5
(5E)-5-(3-Iodo-5-methoxy-4-{2-[2-(prop-2-en-1-yl)phenoxy]ethoxy}benzylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one
CAS 6188-74-5C23H22INO4S2
(5E)-5-[[4-[2-(4-tert-Butylphenoxy)ethoxy]-3-ethoxyphenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C25H29NO4S2, CAS 299961-29-8
(5E)-5-[[4-[2-(4-tert-Butylphenoxy)ethoxy]-3-ethoxyphenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299961-29-8C25H29NO4S2
(5E)-5-[[3-Bromo-5-methoxy-4-[2-(2-prop-2-enylphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C23H22BrNO4S2, CAS 300367-57-1
(5E)-5-[[3-Bromo-5-methoxy-4-[2-(2-prop-2-enylphenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 300367-57-1C23H22BrNO4S2
3-Ethyl-5-{4-[2-(3-methoxyphenoxy)ethoxy]benzylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H21NO4S2, CAS 6193-64-2
3-Ethyl-5-{4-[2-(3-methoxyphenoxy)ethoxy]benzylidene}-2-thioxo-1,3-thiazolidin-4-one
CAS 6193-64-2C21H21NO4S2
(5E)-5-{4-[2-(3-Methoxyphenoxy)ethoxy]benzylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H17NO4S2, CAS 299905-84-3
(5E)-5-{4-[2-(3-Methoxyphenoxy)ethoxy]benzylidene}-2-thioxo-1,3-thiazolidin-4-one
CAS 299905-84-3C19H17NO4S2
(5E)-5-[[3-Chloro-4-[2-(3-ethyl-5-methylphenoxy)ethoxy]-5-methoxyphenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C23H24ClNO4S2, CAS 300385-53-9
(5E)-5-[[3-Chloro-4-[2-(3-ethyl-5-methylphenoxy)ethoxy]-5-methoxyphenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 300385-53-9C23H24ClNO4S2
(5E)-5-[[4-[2-(3-Methoxyphenoxy)ethoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C22H21NO4S2, CAS 6230-85-9
(5E)-5-[[4-[2-(3-Methoxyphenoxy)ethoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 6230-85-9C22H21NO4S2
(5E)-5-[[3-Methoxy-4-[2-(4-nitrophenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H18N2O6S2, CAS 6235-75-2
(5E)-5-[[3-Methoxy-4-[2-(4-nitrophenoxy)ethoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 6235-75-2C20H18N2O6S2