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Murcko scaffold

1-(Phenylsulfonyl)-2-pyrrolidinone scaffold

61 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
61
With full pages
5
Scaffold SMILES

O=C1CCCN1S(=O)(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Phenylsulfonyl)-2-pyrrolidinone page
Murcko scaffold O=C1CCCN1S(=O)(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 61 chemicals

1-((4-Methylphenyl)sulfonyl)-5-oxoproline chemical structure, C12H13NO5S, CAS 6970-25-8
1-((4-Methylphenyl)sulfonyl)-5-oxoproline
CAS 6970-25-8C12H13NO5S
1-(Benzenesulfonyl)-5-ethoxypyrrolidin-2-one chemical structure, C12H15NO4S, CAS 111711-47-8
1-(Benzenesulfonyl)-5-ethoxypyrrolidin-2-one
CAS 111711-47-8C12H15NO4S
1-(4-Methylbenzene-1-sulfonyl)-5-oxoproline--cyclohexanamine (1/1) chemical structure, C18H26N2O5S, CAS 7770-20-9
1-(4-Methylbenzene-1-sulfonyl)-5-oxoproline--cyclohexanamine (1/1)
CAS 7770-20-9C18H26N2O5S
1-(p-Toluenesulfonyl)-2-pyrrolidinone chemical structure, C11H13NO3S, CAS 10019-95-1
1-(p-Toluenesulfonyl)-2-pyrrolidinone
CAS 10019-95-1C11H13NO3S
2-Pyrrolidinone, 1-((4-chlorophenyl)sulfonyl)- chemical structure, C10H10ClNO3S, CAS 73096-15-8
2-Pyrrolidinone, 1-((4-chlorophenyl)sulfonyl)-
CAS 73096-15-8C10H10ClNO3S
1-(Phenylsulfonyl)-2-pyrrolidinone chemical structure, C10H11NO3S, CAS 88000-68-4
1-(Phenylsulfonyl)-2-pyrrolidinone
CAS 88000-68-4C10H11NO3S
1-[(2,4,6-Trimethylphenyl)sulfonyl]pyrrolidin-2-one chemical structure, C13H17NO3S, CAS 298193-11-0
1-[(2,4,6-Trimethylphenyl)sulfonyl]pyrrolidin-2-one
CAS 298193-11-0C13H17NO3S
(2R)-1-(4-Methylphenyl)sulfonyl-5-oxopyrrolidine-2-carboxylic acid chemical structure, C12H13NO5S, CAS 882861-84-9
(2R)-1-(4-Methylphenyl)sulfonyl-5-oxopyrrolidine-2-carboxylic acid
CAS 882861-84-9C12H13NO5S
1-[(4-Methylphenyl)sulfonyl]-5-oxo-L-proline chemical structure, C12H13NO5S, CAS 21957-65-3
1-[(4-Methylphenyl)sulfonyl]-5-oxo-L-proline
CAS 21957-65-3C12H13NO5S
5-Ethoxy-1-(4-nitrobenzene-1-sulfonyl)pyrrolidin-2-one chemical structure, C12H14N2O6S, CAS 111711-48-9
5-Ethoxy-1-(4-nitrobenzene-1-sulfonyl)pyrrolidin-2-one
CAS 111711-48-9C12H14N2O6S
2-Pyrrolidinone, 5-(1-methylethoxy)-1-(phenylsulfonyl)- chemical structure, C13H17NO4S, CAS 111711-49-0
2-Pyrrolidinone, 5-(1-methylethoxy)-1-(phenylsulfonyl)-
CAS 111711-49-0C13H17NO4S
2-Pyrrolidinone, 1-(phenylsulfonyl)-5-propoxy- chemical structure, C13H17NO4S, CAS 111711-50-3
2-Pyrrolidinone, 1-(phenylsulfonyl)-5-propoxy-
CAS 111711-50-3C13H17NO4S
2-Pyrrolidinone, 5-ethoxy-1-((4-methoxyphenyl)sulfonyl)- chemical structure, C13H17NO5S, CAS 111711-51-4
2-Pyrrolidinone, 5-ethoxy-1-((4-methoxyphenyl)sulfonyl)-
CAS 111711-51-4C13H17NO5S
2-Pyrrolidinone, 1-((3,5-bis(trifluoromethyl)phenyl)sulfonyl)-5-ethoxy- chemical structure, C14H13F6NO4S, CAS 111711-53-6
2-Pyrrolidinone, 1-((3,5-bis(trifluoromethyl)phenyl)sulfonyl)-5-ethoxy-
CAS 111711-53-6C14H13F6NO4S
2-Pyrrolidinone, 1-(phenylsulfonyl)-5-(2-propenyloxy)- chemical structure, C13H15NO4S, CAS 136125-52-5
2-Pyrrolidinone, 1-(phenylsulfonyl)-5-(2-propenyloxy)-
CAS 136125-52-5C13H15NO4S
1-(Benzenesulfonyl)-5-ethoxy-3-hydroxypyrrolidin-2-one chemical structure, C12H15NO5S, CAS 120256-72-6
1-(Benzenesulfonyl)-5-ethoxy-3-hydroxypyrrolidin-2-one
CAS 120256-72-6C12H15NO5S
2-Pyrrolidinone, 3-hydroxy-5-(1-methylethoxy)-1-(phenylsulfonyl)-, trans- chemical structure, C13H17NO5S, CAS 120256-73-7
2-Pyrrolidinone, 3-hydroxy-5-(1-methylethoxy)-1-(phenylsulfonyl)-, trans-
CAS 120256-73-7C13H17NO5S
2-Pyrrolidinone, 3,5-diethoxy-1-(phenylsulfonyl)-, trans- chemical structure, C14H19NO5S, CAS 120256-74-8
2-Pyrrolidinone, 3,5-diethoxy-1-(phenylsulfonyl)-, trans-
CAS 120256-74-8C14H19NO5S
2-Pyrrolidinone, 3-(acetyloxy)-5-ethoxy-1-(phenylsulfonyl)-, trans- chemical structure, C14H17NO6S, CAS 120256-75-9
2-Pyrrolidinone, 3-(acetyloxy)-5-ethoxy-1-(phenylsulfonyl)-, trans-
CAS 120256-75-9C14H17NO6S
2-Pyrrolidinone, 5-(ethylthio)-1-(phenylsulfonyl)- chemical structure, C12H15NO3S2, CAS 120257-91-2
2-Pyrrolidinone, 5-(ethylthio)-1-(phenylsulfonyl)-
CAS 120257-91-2C12H15NO3S2
2-Pyrrolidinone, 5-(1-(methylethyl)thio)-1-(phenylsulfonyl)- chemical structure, C13H17NO3S2, CAS 120257-92-3
2-Pyrrolidinone, 5-(1-(methylethyl)thio)-1-(phenylsulfonyl)-
CAS 120257-92-3C13H17NO3S2
2-Pyrrolidinone, 1-((4-chloro-3-(trifluoromethyl)phenyl)sulfonyl)-5-ethoxy- chemical structure, C13H13ClF3NO4S, CAS 111711-54-7
2-Pyrrolidinone, 1-((4-chloro-3-(trifluoromethyl)phenyl)sulfonyl)-5-ethoxy-
CAS 111711-54-7C13H13ClF3NO4S
2-Pyrrolidinone, 1-((3,4-dichlorophenyl)sulfonyl)-5-ethoxy- chemical structure, C12H13Cl2NO4S, CAS 111711-55-8
2-Pyrrolidinone, 1-((3,4-dichlorophenyl)sulfonyl)-5-ethoxy-
CAS 111711-55-8C12H13Cl2NO4S
5-Ethoxy-1-(3-nitrobenzene-1-sulfonyl)pyrrolidin-2-one chemical structure, C12H14N2O6S, CAS 111711-56-9
5-Ethoxy-1-(3-nitrobenzene-1-sulfonyl)pyrrolidin-2-one
CAS 111711-56-9C12H14N2O6S