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Murcko scaffold

1-[2-(1H-Indol-3-yl)ethyl]pyrrolidin-2-one scaffold

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
15
With full pages
3
Scaffold SMILES

O=C1CCCN1CCc1c[nH]c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-[2-(1H-Indol-3-yl)ethyl]pyrrolidin-2-one page
Murcko scaffold O=C1CCCN1CCc1c[nH]c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

1-[2-(1H-Indol-3-yl)ethyl]pyrrolidin-2-one chemical structure, C14H16N2O, CAS 888-19-7
1-[2-(1H-Indol-3-yl)ethyl]pyrrolidin-2-one
CAS 888-19-7C14H16N2O
1-[2-(1H-Indol-3-yl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid chemical structure, C15H16N2O3, CAS 295344-74-0
1-[2-(1H-Indol-3-yl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid
CAS 295344-74-0C15H16N2O3
Methyl 1-[2-(1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylate chemical structure, C16H18N2O3, CAS 4868-78-4
Methyl 1-[2-(1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylate
CAS 4868-78-4C16H18N2O3
1-[2-(5-Chloro-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C15H15ClN2O3, CAS 931374-75-3
1-[2-(5-Chloro-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 931374-75-3C15H15ClN2O3
1-[2-(5-Methyl-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C16H18N2O3, CAS 931374-78-6
1-[2-(5-Methyl-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 931374-78-6C16H18N2O3
1-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C15H15FN2O3, CAS 931374-81-1
1-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 931374-81-1C15H15FN2O3
1-[2-(5-Chloro-1H-indol-3-yl)ethyl]-5-oxo-N-(propan-2-yl)pyrrolidine-3-carboxamide chemical structure, C18H22ClN3O2, CAS 931373-90-9
1-[2-(5-Chloro-1H-indol-3-yl)ethyl]-5-oxo-N-(propan-2-yl)pyrrolidine-3-carboxamide
CAS 931373-90-9C18H22ClN3O2
1-[2-(5-Chloro-1H-indol-3-yl)ethyl]-N-ethyl-5-oxopyrrolidine-3-carboxamide chemical structure, C17H20ClN3O2, CAS 931374-30-0
1-[2-(5-Chloro-1H-indol-3-yl)ethyl]-N-ethyl-5-oxopyrrolidine-3-carboxamide
CAS 931374-30-0C17H20ClN3O2
1-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-5-oxo-N-(propan-2-yl)pyrrolidine-3-carboxamide chemical structure, C18H22FN3O2, CAS 931375-01-8
1-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-5-oxo-N-(propan-2-yl)pyrrolidine-3-carboxamide
CAS 931375-01-8C18H22FN3O2
1-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-5-oxo-N-propylpyrrolidine-3-carboxamide chemical structure, C18H22FN3O2, CAS 931375-45-0
1-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-5-oxo-N-propylpyrrolidine-3-carboxamide
CAS 931375-45-0C18H22FN3O2
1-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-N-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H24FN3O2, CAS 931376-33-9
1-[2-(5-Fluoro-1H-indol-3-yl)ethyl]-N-(2-methylpropyl)-5-oxopyrrolidine-3-carboxamide
CAS 931376-33-9C19H24FN3O2
N-(3-Methoxypropyl)-1-[2-(5-methyl-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H27N3O3, CAS 945210-98-0
N-(3-Methoxypropyl)-1-[2-(5-methyl-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxamide
CAS 945210-98-0C20H27N3O3
1-[2-(5-Methoxy-1H-indol-3-yl)ethyl]pyrrolidin-2-one chemical structure, C15H18N2O2, CAS 190328-45-1
1-[2-(5-Methoxy-1H-indol-3-yl)ethyl]pyrrolidin-2-one
CAS 190328-45-1C15H18N2O2
1-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C16H18N2O4, CAS 1142202-51-4
1-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 1142202-51-4C16H18N2O4
3-Ethyl-1-[2-(1H-indol-3-yl)ethyl]pyrrolidin-2-one chemical structure, C16H20N2O, CAS 88115-34-8
3-Ethyl-1-[2-(1H-indol-3-yl)ethyl]pyrrolidin-2-one
CAS 88115-34-8C16H20N2O