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Murcko scaffold

Ring system with 3 rings and 18 atoms

55 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
55
With full pages
9
Scaffold SMILES

O=C(CC1C(=O)Nc2ccccc21)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)Nc2ccccc21)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

7-Chloro-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one chemical structure, C14H10ClNO3S, CAS 83393-71-9
7-Chloro-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one
CAS 83393-71-9C14H10ClNO3S
3-Hydroxy-3-[2-oxo-2-(2-thienyl)ethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C14H11NO3S, CAS 78660-85-2
3-Hydroxy-3-[2-oxo-2-(2-thienyl)ethyl]-1,3-dihydro-2H-indol-2-one
CAS 78660-85-2C14H11NO3S
5-Bromo-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one chemical structure, C14H10BrNO3S, CAS 83393-69-5
5-Bromo-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one
CAS 83393-69-5C14H10BrNO3S
Ethyl {3-hydroxy-2-oxo-3-[2-oxo-2-(thiophen-2-yl)ethyl]-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C18H17NO5S, CAS 6066-26-8
Ethyl {3-hydroxy-2-oxo-3-[2-oxo-2-(thiophen-2-yl)ethyl]-2,3-dihydro-1H-indol-1-yl}acetate
CAS 6066-26-8C18H17NO5S
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C14H10BrNO3S, CAS 83393-73-1
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 83393-73-1C14H10BrNO3S
3-Hydroxy-5-iodo-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one chemical structure, C14H10INO3S, CAS 486994-42-7
3-Hydroxy-5-iodo-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one
CAS 486994-42-7C14H10INO3S
5-Bromo-3-hydroxy-1-methyl-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C15H12BrNO3S, CAS 356075-56-4
5-Bromo-3-hydroxy-1-methyl-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one
CAS 356075-56-4C15H12BrNO3S
5-Fluoro-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one chemical structure, C14H10FNO3S, CAS 486994-39-2
5-Fluoro-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one
CAS 486994-39-2C14H10FNO3S
5-Ethyl-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one chemical structure, C16H15NO3S, CAS 486994-74-5
5-Ethyl-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)-1H-indol-2-one
CAS 486994-74-5C16H15NO3S
5-Chloro-3-hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C14H10ClNO3S, CAS 355434-76-3
5-Chloro-3-hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one
CAS 355434-76-3C14H10ClNO3S
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-5-chloro-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C14H9BrClNO3S, CAS 356075-52-0
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-5-chloro-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 356075-52-0C14H9BrClNO3S
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-7-methyl-1H-indol-2-one chemical structure, C15H12BrNO3S, CAS 693823-64-2
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-7-methyl-1H-indol-2-one
CAS 693823-64-2C15H12BrNO3S
1-Butyl-3-hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C18H19NO3S, CAS 689740-64-5
1-Butyl-3-hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one
CAS 689740-64-5C18H19NO3S
5-Bromo-1-ethyl-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one chemical structure, C16H14BrNO3S, CAS 689769-82-2
5-Bromo-1-ethyl-3-hydroxy-3-(2-oxo-2-thiophen-2-ylethyl)indol-2-one
CAS 689769-82-2C16H14BrNO3S
4-{3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}butanenitrile chemical structure, C18H15BrN2O3S, CAS 439093-52-4
4-{3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}butanenitrile
CAS 439093-52-4C18H15BrN2O3S
3-[2-(5-Chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-5-methyl-1H-indol-2-one chemical structure, C15H12ClNO3S, CAS 439091-22-2
3-[2-(5-Chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-5-methyl-1H-indol-2-one
CAS 439091-22-2C15H12ClNO3S
3-Hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C17H15NO3S, CAS 439091-24-4
3-Hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one
CAS 439091-24-4C17H15NO3S
4-[3-[2-(5-Chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-2-oxoindol-1-yl]butanenitrile chemical structure, C18H15ClN2O3S, CAS 439093-58-0
4-[3-[2-(5-Chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-2-oxoindol-1-yl]butanenitrile
CAS 439093-58-0C18H15ClN2O3S
2-[3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-2-oxoindol-1-yl]acetamide chemical structure, C16H13BrN2O4S, CAS 439093-42-2
2-[3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-2-oxoindol-1-yl]acetamide
CAS 439093-42-2C16H13BrN2O4S
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-4-chloro-3-hydroxy-7-methyl-1H-indol-2-one chemical structure, C15H11BrClNO3S, CAS 439091-38-0
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-4-chloro-3-hydroxy-7-methyl-1H-indol-2-one
CAS 439091-38-0C15H11BrClNO3S
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-(propan-2-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C17H16BrNO3S, CAS 688038-35-9
3-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-(propan-2-yl)-1,3-dihydro-2H-indol-2-one
CAS 688038-35-9C17H16BrNO3S
Ethyl {3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C18H16ClNO5S, CAS 688037-43-6
Ethyl {3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate
CAS 688037-43-6C18H16ClNO5S
5-Bromo-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C17H13BrClNO3S, CAS 688040-34-8
5-Bromo-3-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one
CAS 688040-34-8C17H13BrClNO3S
3-[2-(5-Chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-propylindol-2-one chemical structure, C17H16ClNO3S, CAS 688037-42-5
3-[2-(5-Chlorothiophen-2-yl)-2-oxoethyl]-3-hydroxy-1-propylindol-2-one
CAS 688037-42-5C17H16ClNO3S