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Murcko scaffold

Ring system with 3 rings and 18 atoms

42 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
42
With full pages
9
Scaffold SMILES

O=C(CC1C(=O)Nc2ccccc21)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)Nc2ccccc21)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-5-nitro-1,3-dihydro-2H-indol-2-one chemical structure, C14H10N2O6, CAS 83393-63-9
3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-5-nitro-1,3-dihydro-2H-indol-2-one
CAS 83393-63-9C14H10N2O6
3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one chemical structure, C14H11NO4, CAS 5654-03-5
3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one
CAS 5654-03-5C14H11NO4
3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C17H15NO4, CAS 309734-17-6
3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one
CAS 309734-17-6C17H15NO4
5-Bromo-3-[2-(2-furyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C14H10BrNO4, CAS 83393-62-8
5-Bromo-3-[2-(2-furyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 83393-62-8C14H10BrNO4
Ethyl {3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C18H17NO6, CAS 353466-96-3
Ethyl {3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate
CAS 353466-96-3C18H17NO6
3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-1-methylindol-2-one chemical structure, C15H13NO4, CAS 83393-61-7
3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-1-methylindol-2-one
CAS 83393-61-7C15H13NO4
5-Bromo-3-hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-1H-indol-2-one chemical structure, C15H12BrNO4, CAS 439091-86-8
5-Bromo-3-hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-1H-indol-2-one
CAS 439091-86-8C15H12BrNO4
5-Chloro-3-(2-(furan-2-yl)-2-oxoethyl)-3-hydroxyindolin-2-one chemical structure, C14H10ClNO4, CAS 356099-55-3
5-Chloro-3-(2-(furan-2-yl)-2-oxoethyl)-3-hydroxyindolin-2-one
CAS 356099-55-3C14H10ClNO4
1-Ethyl-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one chemical structure, C16H15NO4, CAS 356081-50-0
1-Ethyl-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one
CAS 356081-50-0C16H15NO4
3-Hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-1H-indol-2-one chemical structure, C15H13NO4, CAS 367276-69-5
3-Hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-1H-indol-2-one
CAS 367276-69-5C15H13NO4
4-{3-Hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}butanenitrile chemical structure, C19H18N2O4, CAS 439093-54-6
4-{3-Hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}butanenitrile
CAS 439093-54-6C19H18N2O4
3-(2-(Furan-2-yl)-2-oxoethyl)-3-hydroxy-5-methylindolin-2-one chemical structure, C15H13NO4, CAS 439091-17-5
3-(2-(Furan-2-yl)-2-oxoethyl)-3-hydroxy-5-methylindolin-2-one
CAS 439091-17-5C15H13NO4
Methyl {3-hydroxy-3-[2-(5-methyl-2-furyl)-2-oxoethyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C18H17NO6, CAS 439092-04-3
Methyl {3-hydroxy-3-[2-(5-methyl-2-furyl)-2-oxoethyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate
CAS 439092-04-3C18H17NO6
4-[3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-2-oxoindol-1-yl]butanenitrile chemical structure, C18H16N2O4, CAS 439093-48-8
4-[3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-2-oxoindol-1-yl]butanenitrile
CAS 439093-48-8C18H16N2O4
3-Hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-1-prop-2-ynylindol-2-one chemical structure, C18H15NO4, CAS 439092-01-0
3-Hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-1-prop-2-ynylindol-2-one
CAS 439092-01-0C18H15NO4
5-Bromo-1-butyl-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C18H18BrNO4, CAS 688040-15-5
5-Bromo-1-butyl-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 688040-15-5C18H18BrNO4
3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-1,7-dimethylindol-2-one chemical structure, C16H15NO4, CAS 709009-04-1
3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-1,7-dimethylindol-2-one
CAS 709009-04-1C16H15NO4
1-Butyl-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one chemical structure, C18H19NO4, CAS 689740-56-5
1-Butyl-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one
CAS 689740-56-5C18H19NO4
5-Bromo-1-ethyl-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one chemical structure, C16H14BrNO4, CAS 689769-70-8
5-Bromo-1-ethyl-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxyindol-2-one
CAS 689769-70-8C16H14BrNO4
5-Bromo-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-7-methyl-1H-indol-2-one chemical structure, C15H12BrNO4, CAS 712321-90-9
5-Bromo-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-7-methyl-1H-indol-2-one
CAS 712321-90-9C15H12BrNO4
7-Bromo-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1,5-dimethylindol-2-one chemical structure, C16H14BrNO4, CAS 712322-53-7
7-Bromo-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1,5-dimethylindol-2-one
CAS 712322-53-7C16H14BrNO4
5-Fluoro-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one chemical structure, C14H10FNO4, CAS 712325-76-3
5-Fluoro-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one
CAS 712325-76-3C14H10FNO4
6-Chloro-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-7-methyl-1H-indol-2-one chemical structure, C15H12ClNO4, CAS 712335-59-6
6-Chloro-3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-7-methyl-1H-indol-2-one
CAS 712335-59-6C15H12ClNO4
3-Hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-1-prop-2-enylindol-2-one chemical structure, C18H17NO4, CAS 439091-88-0
3-Hydroxy-3-[2-(5-methylfuran-2-yl)-2-oxoethyl]-1-prop-2-enylindol-2-one
CAS 439091-88-0C18H17NO4