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Murcko scaffold

Ring system with 4 rings and 26 atoms

96 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
96
With full pages
64
Scaffold SMILES

O=C1CCCC2=C1C(c1ccccc1)C(C(=O)Nc1ccccn1)=CN2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCCC2=C1C(c1ccccc1)C(C(=O)Nc1ccccn1)=CN2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 96 chemicals

4-(2,4-Dimethoxyphenyl)-2,7,7-trimethyl-N-(4-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C27H31N3O4, CAS 361195-31-5
4-(2,4-Dimethoxyphenyl)-2,7,7-trimethyl-N-(4-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 361195-31-5C27H31N3O4
N-(5-Bromopyridin-2-yl)-4-(4-fluorophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxamide chemical structure, C24H23BrFN3O2, CAS 361195-38-2
N-(5-Bromopyridin-2-yl)-4-(4-fluorophenyl)-2,7,7-trimethyl-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxamide
CAS 361195-38-2C24H23BrFN3O2
4-(3-Methoxyphenyl)-2,7,7-trimethyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C26H29N3O3, CAS 354793-85-4
4-(3-Methoxyphenyl)-2,7,7-trimethyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 354793-85-4C26H29N3O3
N-(5-Bromopyridin-2-yl)-2-methyl-5-oxo-4-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide chemical structure, C22H20BrN3O2, CAS 361193-44-4
N-(5-Bromopyridin-2-yl)-2-methyl-5-oxo-4-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS 361193-44-4C22H20BrN3O2
2,7,7-Trimethyl-N-(6-methylpyridin-2-yl)-5-oxo-4-(3,4,5-trimethoxyphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxamide chemical structure, C28H33N3O5, CAS 361195-55-3
2,7,7-Trimethyl-N-(6-methylpyridin-2-yl)-5-oxo-4-(3,4,5-trimethoxyphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxamide
CAS 361195-55-3C28H33N3O5
4-(2,3-Dimethoxyphenyl)-2-methyl-N-(4-methylpyridin-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide chemical structure, C25H27N3O4, CAS 361193-93-3
4-(2,3-Dimethoxyphenyl)-2-methyl-N-(4-methylpyridin-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
CAS 361193-93-3C25H27N3O4
4-(2,3-Dichlorophenyl)-2-methyl-N-(5-methylpyridin-2-yl)-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide chemical structure, C23H21Cl2N3O2, CAS 6313-48-0
4-(2,3-Dichlorophenyl)-2-methyl-N-(5-methylpyridin-2-yl)-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS 6313-48-0C23H21Cl2N3O2
N-(5-Bromopyridin-2-yl)-4-(4-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide chemical structure, C23H22BrN3O3, CAS 361195-14-4
N-(5-Bromopyridin-2-yl)-4-(4-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS 361195-14-4C23H22BrN3O3
2,7,7-Trimethyl-N-(6-methyl-2-pyridinyl)-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C25H26N4O4, CAS 361194-50-5
2,7,7-Trimethyl-N-(6-methyl-2-pyridinyl)-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 361194-50-5C25H26N4O4
4-(4-Fluorophenyl)-2,7,7-trimethyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C25H26FN3O2, CAS 361195-39-3
4-(4-Fluorophenyl)-2,7,7-trimethyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 361195-39-3C25H26FN3O2
4-(4-Bromophenyl)-2,7,7-trimethyl-5-oxo-N-pyridin-2-yl-1,4,6,8-tetrahydroquinoline-3-carboxamide chemical structure, C24H24BrN3O2, CAS 354794-31-3
4-(4-Bromophenyl)-2,7,7-trimethyl-5-oxo-N-pyridin-2-yl-1,4,6,8-tetrahydroquinoline-3-carboxamide
CAS 354794-31-3C24H24BrN3O2
4-(3-Bromophenyl)-2-methyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C23H22BrN3O2, CAS 361194-20-9
4-(3-Bromophenyl)-2-methyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 361194-20-9C23H22BrN3O2
4-(2,5-Dimethoxyphenyl)-2-methyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C25H27N3O4, CAS 361193-78-4
4-(2,5-Dimethoxyphenyl)-2-methyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 361193-78-4C25H27N3O4
4-(3-Chlorophenyl)-2,7,7-trimethyl-N-(5-methylpyridin-2-yl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxamide chemical structure, C25H26ClN3O2, CAS 361196-02-3
4-(3-Chlorophenyl)-2,7,7-trimethyl-N-(5-methylpyridin-2-yl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxamide
CAS 361196-02-3C25H26ClN3O2
4-(3-Methoxyphenyl)-2-methyl-N-(4-methylpyridin-2-yl)-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide chemical structure, C24H25N3O3, CAS 361193-59-1
4-(3-Methoxyphenyl)-2-methyl-N-(4-methylpyridin-2-yl)-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS 361193-59-1C24H25N3O3
4-(2,4-Dichlorophenyl)-2-methyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C23H21Cl2N3O2, CAS 400845-97-8
4-(2,4-Dichlorophenyl)-2-methyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 400845-97-8C23H21Cl2N3O2
4-(4-Chlorophenyl)-2-methyl-N-(6-methylpyridin-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide chemical structure, C23H22ClN3O2, CAS 361194-87-8
4-(4-Chlorophenyl)-2-methyl-N-(6-methylpyridin-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
CAS 361194-87-8C23H22ClN3O2
4-(4-Bromophenyl)-2-methyl-N-(4-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C23H22BrN3O2, CAS 361195-62-2
4-(4-Bromophenyl)-2-methyl-N-(4-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 361195-62-2C23H22BrN3O2
2,7,7-Trimethyl-5-oxo-N-pyridin-2-yl-4-(3,4,5-trimethoxyphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxamide chemical structure, C27H31N3O5, CAS 361195-53-1
2,7,7-Trimethyl-5-oxo-N-pyridin-2-yl-4-(3,4,5-trimethoxyphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxamide
CAS 361195-53-1C27H31N3O5
4-(2,5-Dimethoxyphenyl)-2,7,7-trimethyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C27H31N3O4, CAS 354793-92-3
4-(2,5-Dimethoxyphenyl)-2,7,7-trimethyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 354793-92-3C27H31N3O4
4-(4-(Dimethylamino)phenyl)-2,7,7-trimethyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C27H32N4O2, CAS 354118-83-5
4-(4-(Dimethylamino)phenyl)-2,7,7-trimethyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 354118-83-5C27H32N4O2
4-(2-Methoxyphenyl)-2-methyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide chemical structure, C24H25N3O3, CAS 361194-09-4
4-(2-Methoxyphenyl)-2-methyl-N-(6-methyl-2-pyridinyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
CAS 361194-09-4C24H25N3O3
2-Methyl-N-(4-methylpyridin-2-yl)-5-oxo-4-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide chemical structure, C26H29N3O5, CAS 361195-51-9
2-Methyl-N-(4-methylpyridin-2-yl)-5-oxo-4-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
CAS 361195-51-9C26H29N3O5
4-(4-Chlorophenyl)-2-methyl-N-(5-methylpyridin-2-yl)-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide chemical structure, C23H22ClN3O2, CAS 361194-88-9
4-(4-Chlorophenyl)-2-methyl-N-(5-methylpyridin-2-yl)-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS 361194-88-9C23H22ClN3O2