Murcko scaffold
Ring system with 4 rings and 28 atoms
13 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 28
- Chemicals
- 13
- With full pages
- 3
Scaffold SMILES
O=C(NNc1nc2ccccc2s1)c1ccc(S(=O)(=O)N2CCNCC2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 13 of 13 chemicals
![Ethyl 4-((4-(2-(4,5-dimethylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C23H27N5O5S2, CAS 851980-57-9](/s/RZEVTLSRXGMYAT-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(4,5-dimethylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851980-57-9C23H27N5O5S2
![Ethyl 4-((4-(2-(5,7-dimethylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C23H27N5O5S2, CAS 851987-61-6](/s/AVFUJRZKCHGNOF-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(5,7-dimethylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851987-61-6C23H27N5O5S2
![Ethyl 4-((4-(2-(4,6-dimethylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C23H27N5O5S2, CAS 851987-33-2](/s/IMLVCASAGOAUAF-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(4,6-dimethylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851987-33-2C23H27N5O5S2
![Ethyl 4-((4-(2-(6-chlorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C21H22ClN5O5S2, CAS 851980-27-3](/s/AWONOMOUJUIQSM-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(6-chlorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851980-27-3C21H22ClN5O5S2
![Ethyl 4-((4-(2-(4-methylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C22H25N5O5S2, CAS 851978-03-5](/s/ZLSBQISVXSOJGH-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(4-methylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851978-03-5C22H25N5O5S2
![Ethyl 4-((4-(2-(4,7-dimethoxybenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C23H27N5O7S2, CAS 851988-06-2](/s/ULIBLANJANCFKO-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(4,7-dimethoxybenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851988-06-2C23H27N5O7S2
![Ethyl 4-((4-(2-(4-methoxybenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C22H25N5O6S2, CAS 851978-40-0](/s/JTVNQZCUXSLDHB-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(4-methoxybenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851978-40-0C22H25N5O6S2
![Ethyl 4-((4-(2-(4-fluorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C21H22FN5O5S2, CAS 851978-89-7](/s/DIAYXDLSYLSJAA-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(4-fluorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851978-89-7C21H22FN5O5S2
![Ethyl 4-((4-(2-(4-chlorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C21H22ClN5O5S2, CAS 851979-26-5](/s/LSYOHUACFUGNDI-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(4-chlorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851979-26-5C21H22ClN5O5S2
![Ethyl 4-((4-(2-(6-methoxybenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C22H25N5O6S2, CAS 851979-85-6](/s/HQHPYHQWTHEDTM-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(6-methoxybenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851979-85-6C22H25N5O6S2
![Ethyl 4-((4-(2-(6-fluorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C21H22FN5O5S2, CAS 851980-10-4](/s/GAQZHSHFCJETHE-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(6-fluorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851980-10-4C21H22FN5O5S2
![Ethyl 4-((4-(2-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C23H27N5O6S2, CAS 851987-83-2](/s/IMNFGSDPHWJZBW-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851987-83-2C23H27N5O6S2
![Ethyl 4-((4-(2-(4,6-difluorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate chemical structure, C21H21F2N5O5S2, CAS 851988-37-9](/s/DJIUJHRGWHBUID-UHFFFAOYSA-N.svg)
Ethyl 4-((4-(2-(4,6-difluorobenzo[d]thiazol-2-yl)hydrazinecarbonyl)phenyl)sulfonyl)piperazine-1-carboxylate
CAS 851988-37-9C21H21F2N5O5S2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(NN=c1[nH]c2ccccc2s1)c1ccc(S(=O)(=O)N2CCCCC2)cc1](/scaffold/XHCUNGCGODESBD-UHFFFAOYSA-N/structure.svg)
O=C(NN=c1[nH]c2ccccc2s1)c1ccc(S(=O)(=O)N2CCCCC2)cc15 chemicals
O=C(CCN1C(=O)c2ccccc2C1=O)N1CCN(Cc2ccccc2)CC13 chemicals
O=C(CN1C(=O)c2ccccc2C1=O)Nc1ccc(S(=O)(=O)N2CCOCC2)cc12 chemicals
O=C(CCN1C(=O)c2ccccc2C1=O)N1CCN(C(=O)c2ccccc2)CC11 chemical![Scaffold C(=Cc1nc2ccccc2[nH]1)CN1CCN(Cc2ccccc2)CC1](/scaffold/DFNUTPZFNVVIOJ-UHFFFAOYSA-N/structure.svg)
C(=Cc1nc2ccccc2[nH]1)CN1CCN(Cc2ccccc2)CC11 chemical![Scaffold c1ccc(Oc2ccc(OCCc3cc4ccccc4[nH]3)cc2)cc1](/scaffold/DNUJIOUWSPLPKM-UHFFFAOYSA-N/structure.svg)
c1ccc(Oc2ccc(OCCc3cc4ccccc4[nH]3)cc2)cc11 chemical![Scaffold O=C(NCc1ccc(S(=O)(=O)c2ccccc2)cc1)c1cc2cnccc2[nH]1](/scaffold/LGQSNALVWIMFPP-UHFFFAOYSA-N/structure.svg)
O=C(NCc1ccc(S(=O)(=O)c2ccccc2)cc1)c1cc2cnccc2[nH]11 chemical
O=C(CN1CCN(Cc2ccccc2)CC1)Nc1nc2ccccc2s11 chemical![Scaffold O=C(CSc1nc2ncccc2[nH]1)N1CCC(Cc2ccccc2)CC1](/scaffold/VTRAHMWJDGPJTF-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc2ncccc2[nH]1)N1CCC(Cc2ccccc2)CC11 chemical
O=C(CN1C(=O)c2ccccc2S1(=O)=O)Nc1ccc(S(=O)(=O)N2CCCCC2)cc11 chemical