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Murcko scaffold

1-Phenyl-1,4-dihydroisoquinolin-3(2H)-one scaffold

42 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
42
With full pages
6
Scaffold SMILES

O=C1Cc2ccccc2C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-1,4-dihydroisoquinolin-3(2H)-one page
Murcko scaffold O=C1Cc2ccccc2C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

1-Phenyl-1,4-dihydroisoquinolin-3(2H)-one chemical structure, C15H13NO, CAS 17507-05-0
1-Phenyl-1,4-dihydroisoquinolin-3(2H)-one
CAS 17507-05-0C15H13NO
Acetanilide, 4'-(3-oxo-1,2,3,4-tetrahydro-1-isoquinolyl)-2-(propylamino)- chemical structure, C20H23N3O2, CAS 54087-38-6
Acetanilide, 4'-(3-oxo-1,2,3,4-tetrahydro-1-isoquinolyl)-2-(propylamino)-
CAS 54087-38-6C20H23N3O2
Acetanilide, 4'-(4-isopropyl-3-oxo-1,2,3,4-tetrahydro-1-isoquinolyl)-2-(propylamino)- chemical structure, C23H29N3O2, CAS 54087-41-1
Acetanilide, 4'-(4-isopropyl-3-oxo-1,2,3,4-tetrahydro-1-isoquinolyl)-2-(propylamino)-
CAS 54087-41-1C23H29N3O2
Acetanilide, 2-(methylamino)-4'-(3-oxo-1,2,3,4-tetrahydro-1-isoquinolyl)- chemical structure, C18H19N3O2, CAS 54087-44-4
Acetanilide, 2-(methylamino)-4'-(3-oxo-1,2,3,4-tetrahydro-1-isoquinolyl)-
CAS 54087-44-4C18H19N3O2
Isoquinolin-3-one, 1,2,3,4-tetrahydro-1-(p-aminophenyl)-, hydrochloride chemical structure, C15H15ClN2O, CAS 64097-17-2
Isoquinolin-3-one, 1,2,3,4-tetrahydro-1-(p-aminophenyl)-, hydrochloride
CAS 64097-17-2C15H15ClN2O
1-(4-Aminophenyl)-1,4-dihydroisoquinolin-3(2H)-one chemical structure, C15H14N2O, CAS 54087-54-6
1-(4-Aminophenyl)-1,4-dihydroisoquinolin-3(2H)-one
CAS 54087-54-6C15H14N2O
3(2H)-Isoquinolinone, 1,4-dihydro-1-(4-aminophenyl)-4-(1-methylethyl)- chemical structure, C18H20N2O, CAS 40119-27-5
3(2H)-Isoquinolinone, 1,4-dihydro-1-(4-aminophenyl)-4-(1-methylethyl)-
CAS 40119-27-5C18H20N2O
Acetamide, 2-(ethylamino)-N-(4-(1,2,3,4-tetrahydro-4,4-dimethyl-3-oxo-1-isoquinolinyl)phenyl)- chemical structure, C21H25N3O2, CAS 54087-43-3
Acetamide, 2-(ethylamino)-N-(4-(1,2,3,4-tetrahydro-4,4-dimethyl-3-oxo-1-isoquinolinyl)phenyl)-
CAS 54087-43-3C21H25N3O2
3(2H)-Isoquinolinone, 1,4-dihydro-1-(4-aminophenyl)-4,4-dimethyl- chemical structure, C17H18N2O, CAS 40119-29-7
3(2H)-Isoquinolinone, 1,4-dihydro-1-(4-aminophenyl)-4,4-dimethyl-
CAS 40119-29-7C17H18N2O
1-(4-Aminophenyl)-1,4-dihydro-4,4,7-trimethyl-3(2H)-isoquinolinone chemical structure, C18H20N2O, CAS 40119-35-5
1-(4-Aminophenyl)-1,4-dihydro-4,4,7-trimethyl-3(2H)-isoquinolinone
CAS 40119-35-5C18H20N2O
1-(2,4-Dichlorophenyl)-1,4-dihydroisoquinolin-3(2H)-one chemical structure, C15H11Cl2NO, CAS 22990-11-0
1-(2,4-Dichlorophenyl)-1,4-dihydroisoquinolin-3(2H)-one
CAS 22990-11-0C15H11Cl2NO
1-(4-Chlorophenyl)-1,4-dihydro-3(2H)-isoquinolinone chemical structure, C15H12ClNO, CAS 22989-91-9
1-(4-Chlorophenyl)-1,4-dihydro-3(2H)-isoquinolinone
CAS 22989-91-9C15H12ClNO
1-(2-Chlorophenyl)-1,4-dihydro-3(2H)-isoquinolinone chemical structure, C15H12ClNO, CAS 98788-13-7
1-(2-Chlorophenyl)-1,4-dihydro-3(2H)-isoquinolinone
CAS 98788-13-7C15H12ClNO
1-(4-Chlorophenyl)-6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone chemical structure, C17H16ClNO3, CAS 98788-26-2
1-(4-Chlorophenyl)-6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone
CAS 98788-26-2C17H16ClNO3
3(2H)-Isoquinolinone, 1,4-dihydro-6,7-dimethoxy-1-phenyl- chemical structure, C17H17NO3, CAS 22990-16-5
3(2H)-Isoquinolinone, 1,4-dihydro-6,7-dimethoxy-1-phenyl-
CAS 22990-16-5C17H17NO3
3(2H)-Isoquinolinone, 1-(2,6-dichlorophenyl)-1,4-dihydro- chemical structure, C15H11Cl2NO, CAS 59214-83-4
3(2H)-Isoquinolinone, 1-(2,6-dichlorophenyl)-1,4-dihydro-
CAS 59214-83-4C15H11Cl2NO
Acetamide, 2-(propylamino)-N-(4-(1,2,3,4-tetrahydro-4,4-dimethyl-3-oxo-1-isoquinolinyl)phenyl)- chemical structure, C22H27N3O2, CAS 54087-39-7
Acetamide, 2-(propylamino)-N-(4-(1,2,3,4-tetrahydro-4,4-dimethyl-3-oxo-1-isoquinolinyl)phenyl)-
CAS 54087-39-7C22H27N3O2
Acetamide, 2-(propylamino)-N-(4-(1,2,3,4-tetrahydro-4-methyl-3-oxo-1-isoquinolinyl)phenyl)- chemical structure, C21H25N3O2, CAS 54087-40-0
Acetamide, 2-(propylamino)-N-(4-(1,2,3,4-tetrahydro-4-methyl-3-oxo-1-isoquinolinyl)phenyl)-
CAS 54087-40-0C21H25N3O2
Acetamide, 2-(ethylamino)-N-(4-(1,2,3,4-tetrahydro-3-oxo-1-isoquinolinyl)phenyl)- chemical structure, C19H21N3O2, CAS 54087-42-2
Acetamide, 2-(ethylamino)-N-(4-(1,2,3,4-tetrahydro-3-oxo-1-isoquinolinyl)phenyl)-
CAS 54087-42-2C19H21N3O2
Acetamide, 2-((1-methylethyl)amino)-N-(4-(1,2,3,4-tetrahydro-3-oxo-1-isoquinolinyl)phenyl)- chemical structure, C20H23N3O2, CAS 54087-45-5
Acetamide, 2-((1-methylethyl)amino)-N-(4-(1,2,3,4-tetrahydro-3-oxo-1-isoquinolinyl)phenyl)-
CAS 54087-45-5C20H23N3O2
Acetamide, 2-((1-methylethyl)amino)-N-(4-(1,2,3,4-tetrahydro-4,4-dimethyl-3-oxo-1-isoquinolinyl)phenyl)- chemical structure, C22H27N3O2, CAS 54087-48-8
Acetamide, 2-((1-methylethyl)amino)-N-(4-(1,2,3,4-tetrahydro-4,4-dimethyl-3-oxo-1-isoquinolinyl)phenyl)-
CAS 54087-48-8C22H27N3O2
Acetamide, 2-(butylamino)-N-(4-(1,2,3,4-tetrahydro-4,4-dimethyl-3-oxo-1-isoquinolinyl)phenyl)- chemical structure, C23H29N3O2, CAS 54087-50-2
Acetamide, 2-(butylamino)-N-(4-(1,2,3,4-tetrahydro-4,4-dimethyl-3-oxo-1-isoquinolinyl)phenyl)-
CAS 54087-50-2C23H29N3O2
Acetanilide, 2-diethylamino-4'-(4,4-dimethyl-3-oxo-1,2,3,4-tetrahydroisoquinol-1-yl)- chemical structure, C23H29N3O2, CAS 54087-51-3
Acetanilide, 2-diethylamino-4'-(4,4-dimethyl-3-oxo-1,2,3,4-tetrahydroisoquinol-1-yl)-
CAS 54087-51-3C23H29N3O2
3(2H)-Isoquinolinone, 1,4-dihydro-1-(4-aminophenyl)-4-methyl- chemical structure, C16H16N2O, CAS 54087-55-7
3(2H)-Isoquinolinone, 1,4-dihydro-1-(4-aminophenyl)-4-methyl-
CAS 54087-55-7C16H16N2O