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Murcko scaffold

Ring system with 3 rings and 21 atoms

19 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
19
With full pages
3
Scaffold SMILES

c1ccc(OCCNCCc2ccc3c(c2)CCN3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(OCCNCCc2ccc3c(c2)CCN3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

(S)-Silodosin chemical structure, C25H32F3N3O4, CAS 2182279-45-2
(S)-Silodosin
CAS 2182279-45-2C25H32F3N3O4
Silodosin chemical structure, C25H32F3N3O4, CAS 160970-54-7
Silodosin
CAS 160970-54-7C25H32F3N3O4
1-(3-Hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)-2,3-dihydro-1H-indole-7-carboxamide chemical structure, C25H32F3N3O4, CAS 160970-64-9
1-(3-Hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)-2,3-dihydro-1H-indole-7-carboxamide
CAS 160970-64-9C25H32F3N3O4
2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile chemical structure, C25H30F3N3O3, CAS 885340-13-6
2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile
CAS 885340-13-6C25H30F3N3O3
O-Acetyl silodosin chemical structure, C27H34F3N3O5, CAS 160970-86-5
O-Acetyl silodosin
CAS 160970-86-5C27H34F3N3O5
1-Acetyl-2,3-dihydro-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile chemical structure, C24H26F3N3O3, CAS 175837-07-7
1-Acetyl-2,3-dihydro-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile
CAS 175837-07-7C24H26F3N3O3
N-tert-Butyloxycarbonyl Silodosin chemical structure, C30H40F3N3O6, CAS 160970-07-0
N-tert-Butyloxycarbonyl Silodosin
CAS 160970-07-0C30H40F3N3O6
Silodosin-d6 chemical structure, C25H32F3N3O4, CAS 1051374-52-7
Silodosin-d6
CAS 1051374-52-7C25H32F3N3O4
Silodosin-d6 DiHCl chemical structure, C25H34Cl2F3N3O4, CAS 1261392-62-4
Silodosin-d6 DiHCl
CAS 1261392-62-4C25H34Cl2F3N3O4
(R)-5-[2-[[2-(2-Ethoxyphenoxy)-ethyl]amino]propyl]-1-(3-hydroxypropyl)-2,3-dihydro-1H-indole-7-carboxamide chemical structure, C25H35N3O4, CAS 239463-74-2
(R)-5-[2-[[2-(2-Ethoxyphenoxy)-ethyl]amino]propyl]-1-(3-hydroxypropyl)-2,3-dihydro-1H-indole-7-carboxamide
CAS 239463-74-2C25H35N3O4
1-(3-Hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxylic acid chemical structure, C25H31F3N2O5, CAS 1431373-77-1
1-(3-Hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxylic acid
CAS 1431373-77-1C25H31F3N2O5
1H-Indole-1-propanoic acid, 7-(aminocarbonyl)-2,3-dihydro-5-((2R)-2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)- chemical structure, C25H30F3N3O5, CAS 1357252-79-9
1H-Indole-1-propanoic acid, 7-(aminocarbonyl)-2,3-dihydro-5-((2R)-2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)-
CAS 1357252-79-9C25H30F3N3O5
(R)-5-(2-((2-(2-(2,2,2-Trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide chemical structure, C22H26F3N3O3, CAS 2755910-23-5
(R)-5-(2-((2-(2-(2,2,2-Trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide
CAS 2755910-23-5C22H26F3N3O3
Deshydroxypropyl silodosin (mixture of isomers) chemical structure, C22H26F3N3O3, CAS 2052161-47-2
Deshydroxypropyl silodosin (mixture of isomers)
CAS 2052161-47-2C22H26F3N3O3
1-(3-Hydroxypropyl)-5-[(2S)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carbonitrile chemical structure, C25H30F3N3O3, CAS 2414147-44-5
1-(3-Hydroxypropyl)-5-[(2S)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carbonitrile
CAS 2414147-44-5C25H30F3N3O3
Silodosin-d4 chemical structure, C25H32F3N3O4, CAS 1426173-86-5
Silodosin-d4
CAS 1426173-86-5C25H32F3N3O4
(R)-1-Acetyl-5-(2-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethylamino)propyl)indoline-7-carbonitrile chemical structure, C25H28F3N3O2, CAS 161024-53-9
(R)-1-Acetyl-5-(2-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethylamino)propyl)indoline-7-carbonitrile
CAS 161024-53-9C25H28F3N3O2
Silodosin N-oxide chemical structure, C25H32F3N3O5, CAS 2361272-05-9
Silodosin N-oxide
CAS 2361272-05-9C25H32F3N3O5
Deuterated silodosin chemical structure, C25H32F3N3O4, CAS 3085544-73-3
Deuterated silodosin
CAS 3085544-73-3C25H32F3N3O4