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Murcko scaffold

Ring system with 3 rings and 19 atoms

93 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
93
With full pages
14
Scaffold SMILES

O=C1CC(N2CCNCC2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(N2CCNCC2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 93 chemicals

4-[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]piperazine-1-carbaldehyde chemical structure, C16H19N3O4, CAS 311783-13-8
4-[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]piperazine-1-carbaldehyde
CAS 311783-13-8C16H19N3O4
1-(4-Ethoxyphenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C17H23N3O3, CAS 21621-46-5
1-(4-Ethoxyphenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 21621-46-5C17H23N3O3
1-(4-Fluorophenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C16H20FN3O3, CAS 333398-66-6
1-(4-Fluorophenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 333398-66-6C16H20FN3O3
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-1-(4-iodophenyl)pyrrolidine-2,5-dione chemical structure, C16H20IN3O3, CAS 312496-51-8
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-1-(4-iodophenyl)pyrrolidine-2,5-dione
CAS 312496-51-8C16H20IN3O3
1-(4-Methoxyphenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C16H21N3O3, CAS 98708-34-0
1-(4-Methoxyphenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 98708-34-0C16H21N3O3
1-(4-Chlorophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C15H18ClN3O2, CAS 299408-37-0
1-(4-Chlorophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 299408-37-0C15H18ClN3O2
1-(3-Chlorophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C15H18ClN3O2, CAS 95498-30-9
1-(3-Chlorophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 95498-30-9C15H18ClN3O2
3-(4-Methyl-piperazin-1-yl)-1-m-tolyl-pyrrolidine-2,5-dione chemical structure, C16H21N3O2, CAS 299408-38-1
3-(4-Methyl-piperazin-1-yl)-1-m-tolyl-pyrrolidine-2,5-dione
CAS 299408-38-1C16H21N3O2
1-(4-Bromophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C15H18BrN3O2, CAS 301354-74-5
1-(4-Bromophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 301354-74-5C15H18BrN3O2
1-(3,4-Dichlorophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C15H17Cl2N3O2, CAS 331966-19-9
1-(3,4-Dichlorophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 331966-19-9C15H17Cl2N3O2
1-(3-Bromophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C15H18BrN3O2, CAS 301354-82-5
1-(3-Bromophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 301354-82-5C15H18BrN3O2
3-(4-Methylpiperazin-1-yl)-1-phenylpyrrolidine-2,5-dione chemical structure, C15H19N3O2, CAS 21621-57-8
3-(4-Methylpiperazin-1-yl)-1-phenylpyrrolidine-2,5-dione
CAS 21621-57-8C15H19N3O2
4-{3-[4-(2-Hydroxyethyl)piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl}benzoic acid chemical structure, C17H21N3O5, CAS 296771-60-3
4-{3-[4-(2-Hydroxyethyl)piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl}benzoic acid
CAS 296771-60-3C17H21N3O5
1-(4-Ethoxyphenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C18H25N3O4, CAS 21621-50-1
1-(4-Ethoxyphenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 21621-50-1C18H25N3O4
1-(4-Bromophenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C16H20BrN3O3, CAS 311332-74-8
1-(4-Bromophenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 311332-74-8C16H20BrN3O3
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione chemical structure, C16H21N3O3, CAS 21621-58-9
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione
CAS 21621-58-9C16H21N3O3
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C17H23N3O4, CAS 313377-60-5
3-[4-(2-Hydroxyethyl)piperazin-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione
CAS 313377-60-5C17H23N3O4
1-(2,4-Dimethylphenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C17H23N3O2, CAS 311331-90-5
1-(2,4-Dimethylphenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 311331-90-5C17H23N3O2
1-(4-Chlorophenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C16H20ClN3O3, CAS 333398-67-7
1-(4-Chlorophenyl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 333398-67-7C16H20ClN3O3
3-(4-Methylpiperazin-1-yl)-1-(4-propoxyphenyl)pyrrolidine-2,5-dione chemical structure, C18H25N3O3, CAS 98708-35-1
3-(4-Methylpiperazin-1-yl)-1-(4-propoxyphenyl)pyrrolidine-2,5-dione
CAS 98708-35-1C18H25N3O3
1-(3,5-Dichlorophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C15H17Cl2N3O2, CAS 333398-91-7
1-(3,5-Dichlorophenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 333398-91-7C15H17Cl2N3O2
1-(3-Methoxyphenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C16H21N3O3, CAS 333398-57-5
1-(3-Methoxyphenyl)-3-(4-methylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 333398-57-5C16H21N3O3
Ethyl 4-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]piperazine-1-carboxylate chemical structure, C20H27N3O5, CAS 352021-32-0
Ethyl 4-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]piperazine-1-carboxylate
CAS 352021-32-0C20H27N3O5
Ethyl 4-[1-(4-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]piperazine-1-carboxylate chemical structure, C17H20FN3O4, CAS 4185-27-7
Ethyl 4-[1-(4-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]piperazine-1-carboxylate
CAS 4185-27-7C17H20FN3O4