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Murcko scaffold

Ring system with 4 rings and 24 atoms

270 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 270
With full pages: 0

Scaffold SMILES

O=C(N=c1ccc2c(=O)n3ccccc3nc2[nH]1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(N=c1ccc2c(=O)n3ccccc3nc2[nH]1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 270 chemicals

(Z)-Ethyl 2-((3-nitrobenzoyl)imino)-5-oxo-1-propyl-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate chemical structure, C24H21N5O6, CAS 534566-18-2

(Z)-Ethyl 2-((3-nitrobenzoyl)imino)-5-oxo-1-propyl-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate

CAS 534566-18-2C₂₄H₂₁N₅O₆

(Z)-Ethyl 2-((3,4-dimethoxybenzoyl)imino)-1-methyl-5-oxo-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate chemical structure, C24H22N4O6, CAS 534565-79-2

(Z)-Ethyl 2-((3,4-dimethoxybenzoyl)imino)-1-methyl-5-oxo-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate

CAS 534565-79-2C₂₄H₂₂N₄O₆

N-[(2E)-3-Cyano-10-methyl-5-oxo-1-pentyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidin-2-ylidene]-4-nitrobenzamide chemical structure, C25H22N6O4, CAS 5291-33-8

N-[(2E)-3-Cyano-10-methyl-5-oxo-1-pentyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidin-2-ylidene]-4-nitrobenzamide

CAS 5291-33-8C₂₅H₂₂N₆O₄

(E)-N-(1-Butyl-3-cyano-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-3-methoxybenzamide chemical structure, C25H23N5O3, CAS 849920-99-6

(E)-N-(1-Butyl-3-cyano-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-3-methoxybenzamide

CAS 849920-99-6C₂₅H₂₃N₅O₃

Ethyl 1-butyl-2-[(4-fluorobenzoyl)imino]-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate chemical structure, C26H25FN4O4, CAS 847339-13-3

Ethyl 1-butyl-2-[(4-fluorobenzoyl)imino]-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate

CAS 847339-13-3C₂₆H₂₅FN₄O₄

(E)-4-(tert-Butyl)-N-(1-butyl-3-cyano-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide chemical structure, C28H29N5O2, CAS 847339-92-8

(E)-4-(tert-Butyl)-N-(1-butyl-3-cyano-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide

CAS 847339-92-8C₂₈H₂₉N₅O₂

(E)-2,4-Dichloro-N-(3-cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide chemical structure, C24H19Cl2N5O2, CAS 573942-05-9

(E)-2,4-Dichloro-N-(3-cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide

CAS 573942-05-9C₂₄H₁₉Cl₂N₅O₂

Ethyl 1-isopropyl-10-methyl-2-[(3-methylbenzoyl)imino]-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate chemical structure, C26H26N4O4, CAS 847364-53-8

Ethyl 1-isopropyl-10-methyl-2-[(3-methylbenzoyl)imino]-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate

CAS 847364-53-8C₂₆H₂₆N₄O₄

(E)-2,4-Dichloro-N-(3-cyano-1-(2-methoxyethyl)-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide chemical structure, C23H17Cl2N5O3, CAS 847365-86-0

(E)-2,4-Dichloro-N-(3-cyano-1-(2-methoxyethyl)-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide

CAS 847365-86-0C₂₃H₁₇Cl₂N₅O₃

N-[3-Cyano-1-(3-isopropoxypropyl)-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene]-2-methylbenzamide chemical structure, C26H25N5O3, CAS 847368-29-0

N-[3-Cyano-1-(3-isopropoxypropyl)-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene]-2-methylbenzamide

CAS 847368-29-0C₂₆H₂₅N₅O₃

(E)-N-(3-Cyano-1-(3-isopropoxypropyl)-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-2,6-difluorobenzamide chemical structure, C26H23F2N5O3, CAS 847379-55-9

(E)-N-(3-Cyano-1-(3-isopropoxypropyl)-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-2,6-difluorobenzamide

CAS 847379-55-9C₂₆H₂₃F₂N₅O₃

(E)-N-(3-Cyano-10-methyl-5-oxo-1-pentyl-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-4-ethoxybenzamide chemical structure, C27H27N5O3, CAS 847380-33-0

(E)-N-(3-Cyano-10-methyl-5-oxo-1-pentyl-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-4-ethoxybenzamide

CAS 847380-33-0C₂₇H₂₇N₅O₃

N-[3-Cyano-1-(3-methoxypropyl)-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene]-3-methylbenzamide chemical structure, C25H23N5O3, CAS 840517-45-5

N-[3-Cyano-1-(3-methoxypropyl)-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene]-3-methylbenzamide

CAS 840517-45-5C₂₅H₂₃N₅O₃

(E)-N-(3-Cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-4-methoxybenzamide chemical structure, C25H23N5O3, CAS 840517-62-6

(E)-N-(3-Cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-4-methoxybenzamide

CAS 840517-62-6C₂₅H₂₃N₅O₃

(E)-3-Chloro-N-(3-cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide chemical structure, C24H20ClN5O2, CAS 840517-70-6

(E)-3-Chloro-N-(3-cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide

CAS 840517-70-6C₂₄H₂₀ClN₅O₂

Ethyl 2-[(3-methoxybenzoyl)imino]-1-(2-methoxyethyl)-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate chemical structure, C26H26N4O6, CAS 850229-84-4

Ethyl 2-[(3-methoxybenzoyl)imino]-1-(2-methoxyethyl)-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate

CAS 850229-84-4C₂₆H₂₆N₄O₆

(E)-4-Chloro-N-(3-cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide chemical structure, C24H20ClN5O2, CAS 840514-76-3

(E)-4-Chloro-N-(3-cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)benzamide

CAS 840514-76-3C₂₄H₂₀ClN₅O₂

Ethyl 1-isopropyl-2-[(3-methoxybenzoyl)imino]-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate chemical structure, C26H26N4O5, CAS 850235-54-0

Ethyl 1-isopropyl-2-[(3-methoxybenzoyl)imino]-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate

CAS 850235-54-0C₂₆H₂₆N₄O₅

N-(1-Butyl-3-cyano-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene)-4-chlorobenzamide chemical structure, C24H20ClN5O2, CAS 843620-57-5

N-(1-Butyl-3-cyano-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene)-4-chlorobenzamide

CAS 843620-57-5C₂₄H₂₀ClN₅O₂

(E)-N-(3-Cyano-1-(3-methoxypropyl)-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-4-methoxybenzamide chemical structure, C25H23N5O4, CAS 577996-46-4

(E)-N-(3-Cyano-1-(3-methoxypropyl)-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-4-methoxybenzamide

CAS 577996-46-4C₂₅H₂₃N₅O₄

N-(3-Cyano-1-isobutyl-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene)-4-fluorobenzamide chemical structure, C24H20FN5O2, CAS 578002-66-1

N-(3-Cyano-1-isobutyl-10-methyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidin-2-ylidene)-4-fluorobenzamide

CAS 578002-66-1C₂₄H₂₀FN₅O₂

Ethyl 2-[(4-methoxybenzoyl)imino]-5-oxo-1-pentyl-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate chemical structure, C27H28N4O5, CAS 847160-13-8

Ethyl 2-[(4-methoxybenzoyl)imino]-5-oxo-1-pentyl-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate

CAS 847160-13-8C₂₇H₂₈N₄O₅

(E)-N-(3-Cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-3-fluorobenzamide chemical structure, C24H20FN5O2, CAS 847160-20-7

(E)-N-(3-Cyano-1-isobutyl-10-methyl-5-oxo-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-2(5H)-ylidene)-3-fluorobenzamide

CAS 847160-20-7C₂₄H₂₀FN₅O₂

Ethyl 2-(benzoylimino)-10-methyl-5-oxo-1-propyl-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate chemical structure, C25H24N4O4, CAS 847163-32-0

Ethyl 2-(benzoylimino)-10-methyl-5-oxo-1-propyl-1,5-dihydro-2H-dipyrido[1,2-a:2,3-d]pyrimidine-3-carboxylate

CAS 847163-32-0C₂₅H₂₄N₄O₄