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Murcko scaffold

Ring system with 5 rings and 28 atoms

197 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
197
With full pages
4
Scaffold SMILES

O=C(C1=CC(=O)N(c2nc3ccccc3s2)C1c1ccccc1)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(c2nc3ccccc3s2)C1c1ccccc1)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 197 chemicals

1-(6-Chloro-1,3-benzothiazol-2-yl)-5-(2-fluorophenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H14ClFN2O4S, CAS 607350-78-7
1-(6-Chloro-1,3-benzothiazol-2-yl)-5-(2-fluorophenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 607350-78-7C23H14ClFN2O4S
1-(6-Fluorobenzothiazol-2-yl)-4-(2-furylcarbonyl)-3-hydroxy-5-(2-methoxyphenyl)-3-pyrrolin-2-one chemical structure, C23H15FN2O5S, CAS 514191-37-8
1-(6-Fluorobenzothiazol-2-yl)-4-(2-furylcarbonyl)-3-hydroxy-5-(2-methoxyphenyl)-3-pyrrolin-2-one
CAS 514191-37-8C23H15FN2O5S
1-(6-Fluorobenzothiazol-2-yl)-5-(3-fluorophenyl)-4-(2-furylcarbonyl)-3-hydroxy-3-pyrrolin-2-one chemical structure, C22H12F2N2O4S, CAS 514191-29-8
1-(6-Fluorobenzothiazol-2-yl)-5-(3-fluorophenyl)-4-(2-furylcarbonyl)-3-hydroxy-3-pyrrolin-2-one
CAS 514191-29-8C22H12F2N2O4S
5-(2,5-Dimethoxyphenyl)-1-(6-ethyl-1,3-benzothiazol-2-yl)-4-(2-furoyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H22N2O6S, CAS 618414-63-4
5-(2,5-Dimethoxyphenyl)-1-(6-ethyl-1,3-benzothiazol-2-yl)-4-(2-furoyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
CAS 618414-63-4C26H22N2O6S
1-(6-Ethylbenzothiazol-2-yl)-4-(2-furylcarbonyl)-3-hydroxy-5-(4-methoxyphenyl)-3-pyrrolin-2-one chemical structure, C25H20N2O5S, CAS 618414-21-4
1-(6-Ethylbenzothiazol-2-yl)-4-(2-furylcarbonyl)-3-hydroxy-5-(4-methoxyphenyl)-3-pyrrolin-2-one
CAS 618414-21-4C25H20N2O5S
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-1-(6-methoxy-1,3-benzothiazol-2-yl)-5-phenylpyrrolidine-2,3-dione chemical structure, C23H16N2O5S, CAS 514187-82-7
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-1-(6-methoxy-1,3-benzothiazol-2-yl)-5-phenylpyrrolidine-2,3-dione
CAS 514187-82-7C23H16N2O5S
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-hydroxy-phenyl)-1-(6-methoxy-benzothiazol-2-yl)-1,5-dihydro-pyrrol-2-one chemical structure, C23H16N2O6S, CAS 607339-51-5
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-hydroxy-phenyl)-1-(6-methoxy-benzothiazol-2-yl)-1,5-dihydro-pyrrol-2-one
CAS 607339-51-5C23H16N2O6S
4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(6-methoxy-1,3-benzothiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H16N2O6S, CAS 607339-73-1
4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(6-methoxy-1,3-benzothiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 607339-73-1C23H16N2O6S
4-(2-Furylcarbonyl)-3-hydroxy-5-(4-hydroxyphenyl)-1-(6-methyl-1,3-benzothiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H16N2O5S, CAS 608114-48-3
4-(2-Furylcarbonyl)-3-hydroxy-5-(4-hydroxyphenyl)-1-(6-methyl-1,3-benzothiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 608114-48-3C23H16N2O5S
4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(6-methyl-1,3-benzothiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H16N2O5S, CAS 608114-72-3
4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(6-methyl-1,3-benzothiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 608114-72-3C23H16N2O5S
3-Hydroxy-5-(4-hydroxy-phenyl)-1-(6-methyl-benzothiazol-2-yl)-4-(5-methyl-furan-2-carbonyl)-1,5-dihydro-pyrrol-2-one chemical structure, C24H18N2O5S, CAS 608114-89-2
3-Hydroxy-5-(4-hydroxy-phenyl)-1-(6-methyl-benzothiazol-2-yl)-4-(5-methyl-furan-2-carbonyl)-1,5-dihydro-pyrrol-2-one
CAS 608114-89-2C24H18N2O5S
1-(4,6-Dimethyl-benzothiazol-2-yl)-4-(furan-2-carbonyl)-3-hydroxy-5-(3-hydroxy-phenyl)-1,5-dihydro-pyrrol-2-one chemical structure, C24H18N2O5S, CAS 608116-32-1
1-(4,6-Dimethyl-benzothiazol-2-yl)-4-(furan-2-carbonyl)-3-hydroxy-5-(3-hydroxy-phenyl)-1,5-dihydro-pyrrol-2-one
CAS 608116-32-1C24H18N2O5S
(4E)-5-(4-Bromophenyl)-1-(4,6-dimethyl-1,3-benzothiazol-2-yl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]pyrrolidine-2,3-dione chemical structure, C25H19BrN2O4S, CAS 514194-92-4
(4E)-5-(4-Bromophenyl)-1-(4,6-dimethyl-1,3-benzothiazol-2-yl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]pyrrolidine-2,3-dione
CAS 514194-92-4C25H19BrN2O4S
2-(4-Bromophenyl)-1-(6-ethyl-1,3-benzothiazol-2-yl)-3-(furan-2-carbonyl)-4-hydroxy-2H-pyrrol-5-one chemical structure, C24H17BrN2O4S, CAS 618414-03-2
2-(4-Bromophenyl)-1-(6-ethyl-1,3-benzothiazol-2-yl)-3-(furan-2-carbonyl)-4-hydroxy-2H-pyrrol-5-one
CAS 618414-03-2C24H17BrN2O4S
(4E)-5-(2,3-Dimethoxyphenyl)-1-(4,6-dimethyl-1,3-benzothiazol-2-yl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]pyrrolidine-2,3-dione chemical structure, C27H24N2O6S, CAS 514194-98-0
(4E)-5-(2,3-Dimethoxyphenyl)-1-(4,6-dimethyl-1,3-benzothiazol-2-yl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]pyrrolidine-2,3-dione
CAS 514194-98-0C27H24N2O6S
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-1-(6-methoxy-1,3-benzothiazol-2-yl)-5-(2-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H18N2O6S, CAS 514187-96-3
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-1-(6-methoxy-1,3-benzothiazol-2-yl)-5-(2-methoxyphenyl)pyrrolidine-2,3-dione
CAS 514187-96-3C24H18N2O6S
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-1-(6-methoxy-1,3-benzothiazol-2-yl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione chemical structure, C26H22N2O8S, CAS 514188-03-5
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-1-(6-methoxy-1,3-benzothiazol-2-yl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione
CAS 514188-03-5C26H22N2O8S
1-(4,6-Dimethylbenzo[d]thiazol-2-yl)-5-(3-fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C24H17FN2O4S, CAS 514194-63-9
1-(4,6-Dimethylbenzo[d]thiazol-2-yl)-5-(3-fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one
CAS 514194-63-9C24H17FN2O4S
1-(6-Ethoxy-1,3-benzothiazol-2-yl)-4-(furan-2-ylcarbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H20N2O6S, CAS 514192-19-9
1-(6-Ethoxy-1,3-benzothiazol-2-yl)-4-(furan-2-ylcarbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 514192-19-9C25H20N2O6S
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-1-(6-methoxy-1,3-benzothiazol-2-yl)-5-(3-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H18N2O6S, CAS 514187-97-4
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-1-(6-methoxy-1,3-benzothiazol-2-yl)-5-(3-methoxyphenyl)pyrrolidine-2,3-dione
CAS 514187-97-4C24H18N2O6S
5-(4-Ethoxyphenyl)-1-(6-fluorobenzothiazol-2-yl)-4-(2-furylcarbonyl)-3-hydroxy-3-pyrrolin-2-one chemical structure, C24H17FN2O5S, CAS 514191-40-3
5-(4-Ethoxyphenyl)-1-(6-fluorobenzothiazol-2-yl)-4-(2-furylcarbonyl)-3-hydroxy-3-pyrrolin-2-one
CAS 514191-40-3C24H17FN2O5S
2-(4-tert-Butylphenyl)-1-(6-ethyl-1,3-benzothiazol-2-yl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-2H-pyrrol-5-one chemical structure, C29H28N2O4S, CAS 618415-22-8
2-(4-tert-Butylphenyl)-1-(6-ethyl-1,3-benzothiazol-2-yl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-2H-pyrrol-5-one
CAS 618415-22-8C29H28N2O4S
1-(4,6-Dimethylbenzothiazol-2-yl)-5-[4-(tert-butyl)phenyl]-4-(2-furylcarbonyl)-3-hydroxy-3-pyrrolin-2-one chemical structure, C28H26N2O4S, CAS 514194-61-7
1-(4,6-Dimethylbenzothiazol-2-yl)-5-[4-(tert-butyl)phenyl]-4-(2-furylcarbonyl)-3-hydroxy-3-pyrrolin-2-one
CAS 514194-61-7C28H26N2O4S
(4E)-1-(4,6-Dimethyl-1,3-benzothiazol-2-yl)-5-(4-fluorophenyl)-4-[furan-2-yl(hydroxy)methylidene]pyrrolidine-2,3-dione chemical structure, C24H17FN2O4S, CAS 514194-64-0
(4E)-1-(4,6-Dimethyl-1,3-benzothiazol-2-yl)-5-(4-fluorophenyl)-4-[furan-2-yl(hydroxy)methylidene]pyrrolidine-2,3-dione
CAS 514194-64-0C24H17FN2O4S