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Murcko scaffold

Ring system with 3 rings and 19 atoms

20 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 20
With full pages: 6

Scaffold SMILES

O=C1NC(=Nc2ccccc2)SC1=Cc1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(=Nc2ccccc2)SC1=Cc1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

2-[(4-Ethoxyphenyl)imino]-3-ethyl-5-(2-thienylmethylene)-1,3-thiazolidin-4-one chemical structure, C18H18N2O2S2, CAS 443876-83-3

2-[(4-Ethoxyphenyl)imino]-3-ethyl-5-(2-thienylmethylene)-1,3-thiazolidin-4-one

CAS 443876-83-3C₁₈H₁₈N₂O₂S₂

2-[(4-Ethoxyphenyl)imino]-3-propyl-5-(2-thienylmethylene)-1,3-thiazolidin-4-one chemical structure, C19H20N2O2S2, CAS 443871-48-5

2-[(4-Ethoxyphenyl)imino]-3-propyl-5-(2-thienylmethylene)-1,3-thiazolidin-4-one

CAS 443871-48-5C₁₉H₂₀N₂O₂S₂

3-Ethyl-2-[(4-methoxyphenyl)imino]-5-(2-thienylmethylene)-1,3-thiazolidin-4-one chemical structure, C17H16N2O2S2, CAS 1164483-82-2

3-Ethyl-2-[(4-methoxyphenyl)imino]-5-(2-thienylmethylene)-1,3-thiazolidin-4-one

CAS 1164483-82-2C₁₇H₁₆N₂O₂S₂

(2E,5E)-5-(Thiophen-2-ylmethylene)-2-(p-tolylimino)thiazolidin-4-one chemical structure, C15H12N2OS2, CAS 312291-31-9

(2E,5E)-5-(Thiophen-2-ylmethylene)-2-(p-tolylimino)thiazolidin-4-one

CAS 312291-31-9C₁₅H₁₂N₂OS₂

(5Z)-2-[(2,3-Dichlorophenyl)amino]-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one chemical structure, C14H8Cl2N2OS2, CAS 381683-43-8

(5Z)-2-[(2,3-Dichlorophenyl)amino]-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one

CAS 381683-43-8C₁₄H₈Cl₂N₂OS₂

(Z)-2-((2,3-Dimethylphenyl)amino)-5-(thiophen-2-ylmethylene)thiazol-4(5H)-one chemical structure, C16H14N2OS2, CAS 308292-36-6

(Z)-2-((2,3-Dimethylphenyl)amino)-5-(thiophen-2-ylmethylene)thiazol-4(5H)-one

CAS 308292-36-6C₁₆H₁₄N₂OS₂

(2E,5E)-2-[(4-Fluorophenyl)imino]-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C14H9FN2OS2, CAS 307541-10-2

(2E,5E)-2-[(4-Fluorophenyl)imino]-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one

CAS 307541-10-2C₁₄H₉FN₂OS₂

(5Z)-2-(4-Bromoanilino)-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4-one chemical structure, C14H9BrN2OS2, CAS 353474-43-8

(5Z)-2-(4-Bromoanilino)-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4-one

CAS 353474-43-8C₁₄H₉BrN₂OS₂

(5Z)-2-[(4-Hydroxyphenyl)amino]-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one chemical structure, C14H10N2O2S2, CAS 461673-94-9

(5Z)-2-[(4-Hydroxyphenyl)amino]-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one

CAS 461673-94-9C₁₄H₁₀N₂O₂S₂

(5E)-2-[(3-Methylphenyl)amino]-5-[(thiophen-2-yl)methylidene]-4,5-dihydro-1,3-thiazol-4-one chemical structure, C15H12N2OS2

(5E)-2-[(3-Methylphenyl)amino]-5-[(thiophen-2-yl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

C₁₅H₁₂N₂OS₂

(5E)-2-(3,4-Dimethylanilino)-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4-one chemical structure, C16H14N2OS2, CAS 1164527-03-0

(5E)-2-(3,4-Dimethylanilino)-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4-one

CAS 1164527-03-0C₁₆H₁₄N₂OS₂

(E)-5-(Thiophen-2-ylmethylene)-2-(m-tolylamino)thiazol-4(5H)-one chemical structure, C15H12N2OS2, CAS 1164545-47-4

(E)-5-(Thiophen-2-ylmethylene)-2-(m-tolylamino)thiazol-4(5H)-one

CAS 1164545-47-4C₁₅H₁₂N₂OS₂

(2E,5E)-2-[(2-Ethoxyphenyl)imino]-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C16H14N2O2S2, CAS 488813-93-0

(2E,5E)-2-[(2-Ethoxyphenyl)imino]-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one

CAS 488813-93-0C₁₆H₁₄N₂O₂S₂

(5Z)-2-(Phenylamino)-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one chemical structure, C14H10N2OS2, CAS 330567-13-0

(5Z)-2-(Phenylamino)-5-(thiophen-2-ylmethylidene)-1,3-thiazol-4(5H)-one

CAS 330567-13-0C₁₄H₁₀N₂OS₂

2-(3-Hydroxyphenylamino)-5-(thiophen-2-ylmethylene)thiazol-4(5H)-one chemical structure, C14H10N2O2S2, CAS 862198-36-5

2-(3-Hydroxyphenylamino)-5-(thiophen-2-ylmethylene)thiazol-4(5H)-one

CAS 862198-36-5C₁₄H₁₀N₂O₂S₂

(2Z,5E)-2-[(2,4-Dimethylphenyl)imino]-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C16H14N2OS2, CAS 638140-12-2

(2Z,5E)-2-[(2,4-Dimethylphenyl)imino]-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one

CAS 638140-12-2C₁₆H₁₄N₂OS₂

(E)-5-(Thiophen-2-ylmethylene)-2-(o-tolylamino)thiazol-4(5H)-one chemical structure, C15H12N2OS2, CAS 638139-85-2

(E)-5-(Thiophen-2-ylmethylene)-2-(o-tolylamino)thiazol-4(5H)-one

CAS 638139-85-2C₁₅H₁₂N₂OS₂

(2E,5Z)-2-[(2-Chlorophenyl)imino]-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C14H9ClN2OS2, CAS 330567-14-1

(2E,5Z)-2-[(2-Chlorophenyl)imino]-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one

CAS 330567-14-1C₁₄H₉ClN₂OS₂

(E)-5-(Thiophen-2-ylmethylene)-2-((3-(trifluoromethyl)phenyl)amino)thiazol-4(5H)-one chemical structure, C15H9F3N2OS2, CAS 638139-89-6

(E)-5-(Thiophen-2-ylmethylene)-2-((3-(trifluoromethyl)phenyl)amino)thiazol-4(5H)-one

CAS 638139-89-6C₁₅H₉F₃N₂OS₂

2-[(4-Methoxyphenyl)amino]-5-[(thiophen-2-yl)methylidene]-4,5-dihydro-1,3-thiazol-4-one chemical structure, C15H12N2O2S2, CAS 402772-71-8

2-[(4-Methoxyphenyl)amino]-5-[(thiophen-2-yl)methylidene]-4,5-dihydro-1,3-thiazol-4-one

CAS 402772-71-8C₁₅H₁₂N₂O₂S₂