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Murcko scaffold

Ring system with 3 rings and 19 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
12
With full pages
3
Scaffold SMILES

O=C1NC(=Nc2ccccc2)SC1=Cc1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=Nc2ccccc2)SC1=Cc1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

2-[(4-Ethoxyphenyl)imino]-5-(2-furylmethylene)-3-propyl-1,3-thiazolidin-4-one chemical structure, C19H20N2O3S, CAS 443875-39-6
2-[(4-Ethoxyphenyl)imino]-5-(2-furylmethylene)-3-propyl-1,3-thiazolidin-4-one
CAS 443875-39-6C19H20N2O3S
5-[1-Furan-2-yl-meth-(Z)-ylidene]-2-(4-methoxy-phenylamino)-thiazol-4-one chemical structure, C15H12N2O3S, CAS 301337-88-2
5-[1-Furan-2-yl-meth-(Z)-ylidene]-2-(4-methoxy-phenylamino)-thiazol-4-one
CAS 301337-88-2C15H12N2O3S
2-(2,3-Dichloroanilino)-5-(2-furylmethylene)-1,3-thiazol-4(5H)-one chemical structure, C14H8Cl2N2O2S, CAS 380865-37-2
2-(2,3-Dichloroanilino)-5-(2-furylmethylene)-1,3-thiazol-4(5H)-one
CAS 380865-37-2C14H8Cl2N2O2S
N-[4-({(5E)-5-[(5-methylfuran-2-yl)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl}amino)phenyl]acetamide chemical structure, C17H15N3O3S, CAS 868142-92-1
N-[4-({(5E)-5-[(5-methylfuran-2-yl)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl}amino)phenyl]acetamide
CAS 868142-92-1C17H15N3O3S
(5E)-5-(Furan-2-ylmethylidene)-2-[(4-hydroxyphenyl)amino]-1,3-thiazol-4(5H)-one chemical structure, C14H10N2O3S, CAS 24045-28-1
(5E)-5-(Furan-2-ylmethylidene)-2-[(4-hydroxyphenyl)amino]-1,3-thiazol-4(5H)-one
CAS 24045-28-1C14H10N2O3S
(2E,5E)-5-[(5-Methylfuran-2-yl)methylidene]-2-[(4-methylphenyl)imino]-1,3-thiazolidin-4-one chemical structure, C16H14N2O2S, CAS 6075-64-5
(2E,5E)-5-[(5-Methylfuran-2-yl)methylidene]-2-[(4-methylphenyl)imino]-1,3-thiazolidin-4-one
CAS 6075-64-5C16H14N2O2S
(2E,5E)-2-((4-Hydroxyphenyl)imino)-5-((5-methylfuran-2-yl)methylene)thiazolidin-4-one chemical structure, C15H12N2O3S, CAS 461673-93-8
(2E,5E)-2-((4-Hydroxyphenyl)imino)-5-((5-methylfuran-2-yl)methylene)thiazolidin-4-one
CAS 461673-93-8C15H12N2O3S
5-{[5-(2-Furylmethylene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]amino}isophthalic acid chemical structure, C16H10N2O6S, CAS 881053-10-7
5-{[5-(2-Furylmethylene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]amino}isophthalic acid
CAS 881053-10-7C16H10N2O6S
4(5H)-Thiazolone,2-[(4-bromo-3,5-dimethylphenyl)amino]-5-[[5-(diethylamino)-2-furanyl]methylene]- chemical structure, C20H22BrN3O2S, CAS 359594-13-1
4(5H)-Thiazolone,2-[(4-bromo-3,5-dimethylphenyl)amino]-5-[[5-(diethylamino)-2-furanyl]methylene]-
CAS 359594-13-1C20H22BrN3O2S
(5E)-2-(5-Chloro-2-methylphenyl)imino-5-[[5-(diethylamino)furan-2-yl]methylidene]-1,3-thiazolidin-4-one chemical structure, C19H20ClN3O2S, CAS 366472-35-7
(5E)-2-(5-Chloro-2-methylphenyl)imino-5-[[5-(diethylamino)furan-2-yl]methylidene]-1,3-thiazolidin-4-one
CAS 366472-35-7C19H20ClN3O2S
4(5H)-Thiazolone,5-[[5-(diethylamino)-2-furanyl]methylene]-2-(phenylamino)- chemical structure, C18H19N3O2S, CAS 366826-63-3
4(5H)-Thiazolone,5-[[5-(diethylamino)-2-furanyl]methylene]-2-(phenylamino)-
CAS 366826-63-3C18H19N3O2S
4(5H)-Thiazolone,5-[[5-(diethylamino)-2-furanyl]methylene]-2-[(2-methylphenyl)amino]- chemical structure, C19H21N3O2S, CAS 366461-03-2
4(5H)-Thiazolone,5-[[5-(diethylamino)-2-furanyl]methylene]-2-[(2-methylphenyl)amino]-
CAS 366461-03-2C19H21N3O2S