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Murcko scaffold

Ring system with 3 rings and 20 atoms

19 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
19
With full pages
4
Scaffold SMILES

O=C1C(=Cc2ccccc2)SC(=S)N1CC1CCCO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccccc2)SC(=S)N1CC1CCCO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

5-[(2-Methoxyphenyl)methylene]-3-[(tetrahydro-2-furanyl)methyl]-2-thioxo-4-thiazolidinone chemical structure, C16H17NO3S2, CAS 331852-17-6
5-[(2-Methoxyphenyl)methylene]-3-[(tetrahydro-2-furanyl)methyl]-2-thioxo-4-thiazolidinone
CAS 331852-17-6C16H17NO3S2
5-[[4-(Difluoromethoxy)phenyl]methylidene]-3-(oxolan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C16H15F2NO3S2
5-[[4-(Difluoromethoxy)phenyl]methylidene]-3-(oxolan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one
C16H15F2NO3S2
(5Z)-5-[(2-Fluorophenyl)methylidene]-3-(oxolan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C15H14FNO2S2, CAS 314046-16-7
(5Z)-5-[(2-Fluorophenyl)methylidene]-3-(oxolan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 314046-16-7C15H14FNO2S2
5(4-Dimethylamino-benzylidene)3-(4H-furan-2-ylmethyl)-2-thioxo-thiazolidin-4-one chemical structure, C17H20N2O2S2, CAS 313966-47-1
5(4-Dimethylamino-benzylidene)3-(4H-furan-2-ylmethyl)-2-thioxo-thiazolidin-4-one
CAS 313966-47-1C17H20N2O2S2
(5Z)-5-(2,4-Dichlorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H13Cl2NO2S2, CAS 324070-89-5
(5Z)-5-(2,4-Dichlorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 324070-89-5C15H13Cl2NO2S2
RefChem:314129 chemical structure, C15H13Cl2NO2S2, CAS 5865-19-0
RefChem:314129
CAS 5865-19-0C15H13Cl2NO2S2
(5Z)-5-(2-Chloro-6-fluorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H13ClFNO2S2, CAS 314046-17-8
(5Z)-5-(2-Chloro-6-fluorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 314046-17-8C15H13ClFNO2S2
(5Z)-5-(4-Fluorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H14FNO2S2, CAS 324546-79-4
(5Z)-5-(4-Fluorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 324546-79-4C15H14FNO2S2
5-(4-Propoxybenzylidene)-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H21NO3S2, CAS 1164475-01-7
5-(4-Propoxybenzylidene)-3-(tetrahydro-2-furanylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 1164475-01-7C18H21NO3S2
(5Z)-5-(3,4-Dimethoxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H19NO4S2, CAS 500279-03-8
(5Z)-5-(3,4-Dimethoxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 500279-03-8C17H19NO4S2
(5Z)-5-(4-Chlorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H14ClNO2S2, CAS 438461-74-6
(5Z)-5-(4-Chlorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 438461-74-6C15H14ClNO2S2
(5Z)-5-(2-Chlorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H14ClNO2S2, CAS 488138-26-7
(5Z)-5-(2-Chlorobenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 488138-26-7C15H14ClNO2S2
(5Z)-5-(4-Hydroxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H15NO3S2, CAS 438460-08-3
(5Z)-5-(4-Hydroxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 438460-08-3C15H15NO3S2
(5Z)-5-(4-Methoxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C16H17NO3S2, CAS 438461-73-5
(5Z)-5-(4-Methoxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 438461-73-5C16H17NO3S2
(5Z)-5-(2,4-Dimethoxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H19NO4S2, CAS 438460-09-4
(5Z)-5-(2,4-Dimethoxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 438460-09-4C17H19NO4S2
5-[[4-(Difluoromethoxy)phenyl]methylene]-3-[(tetrahydro-2-furanyl)methyl]-2-thioxo-4-thiazolidinone chemical structure, C16H15F2NO3S2
5-[[4-(Difluoromethoxy)phenyl]methylene]-3-[(tetrahydro-2-furanyl)methyl]-2-thioxo-4-thiazolidinone
C16H15F2NO3S2
(5Z)-5-(4-Methylbenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C16H17NO2S2, CAS 324070-80-6
(5Z)-5-(4-Methylbenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 324070-80-6C16H17NO2S2
(5Z)-5-(4-tert-Butylbenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H23NO2S2, CAS 438461-72-4
(5Z)-5-(4-tert-Butylbenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 438461-72-4C19H23NO2S2
(E)-5-(4-(Difluoromethoxy)benzylidene)-3-((tetrahydrofuran-2-yl)methyl)-2-thioxothiazolidin-4-one chemical structure, C16H15F2NO3S2, CAS 326871-47-0
(E)-5-(4-(Difluoromethoxy)benzylidene)-3-((tetrahydrofuran-2-yl)methyl)-2-thioxothiazolidin-4-one
CAS 326871-47-0C16H15F2NO3S2