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Murcko scaffold

Ring system with 3 rings and 18 atoms

15 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 18
Chemicals: 15
With full pages: 5

Scaffold SMILES

O=C(CSc1nncs1)N1CCc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nncs1)N1CCc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

1-(2-Methyl-2,3-dihydro-indol-1-yl)-2-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-ethanone chemical structure, C14H15N3OS2, CAS 552828-20-3

1-(2-Methyl-2,3-dihydro-indol-1-yl)-2-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-ethanone

CAS 552828-20-3C₁₄H₁₅N₃OS₂

1-(2,3-Dihydroindol-1-yl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone chemical structure, C13H13N3OS2, CAS 693234-12-7

1-(2,3-Dihydroindol-1-yl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone

CAS 693234-12-7C₁₃H₁₃N₃OS₂

2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-1-(indolin-1-yl)ethanone chemical structure, C12H12N4OS2, CAS 389073-57-8

2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-1-(indolin-1-yl)ethanone

CAS 389073-57-8C₁₂H₁₂N₄OS₂

N-[5-[2-(2,3-Dihydroindol-1-yl)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C14H14N4O2S2, CAS 392300-55-9

N-[5-[2-(2,3-Dihydroindol-1-yl)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]acetamide

CAS 392300-55-9C₁₄H₁₄N₄O₂S₂

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)propionamide chemical structure, C15H16N4O2S2, CAS 392300-56-0

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)propionamide

CAS 392300-56-0C₁₅H₁₆N₄O₂S₂

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)isobutyramide chemical structure, C16H18N4O2S2, CAS 392300-58-2

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)isobutyramide

CAS 392300-58-2C₁₆H₁₈N₄O₂S₂

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)butyramide chemical structure, C16H18N4O2S2, CAS 392300-59-3

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)butyramide

CAS 392300-59-3C₁₆H₁₈N₄O₂S₂

3-Chloro-N-(5-((2-(indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)propanamide chemical structure, C15H15ClN4O2S2, CAS 391868-97-6

3-Chloro-N-(5-((2-(indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)propanamide

CAS 391868-97-6C₁₅H₁₅ClN₄O₂S₂

2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(2-methyl-2,3-dihydro-1H-indol-1-yl)ethanone chemical structure, C13H14N4OS2, CAS 774561-96-5

2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(2-methyl-2,3-dihydro-1H-indol-1-yl)ethanone

CAS 774561-96-5C₁₃H₁₄N₄OS₂

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)pentanamide chemical structure, C17H20N4O2S2, CAS 392300-60-6

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)pentanamide

CAS 392300-60-6C₁₇H₂₀N₄O₂S₂

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-methylbutanamide chemical structure, C17H20N4O2S2, CAS 392300-61-7

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-methylbutanamide

CAS 392300-61-7C₁₇H₂₀N₄O₂S₂

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)pivalamide chemical structure, C17H20N4O2S2, CAS 392300-57-1

N-(5-((2-(Indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)pivalamide

CAS 392300-57-1C₁₇H₂₀N₄O₂S₂

2-Ethyl-N-(5-((2-(indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)butanamide chemical structure, C18H22N4O2S2, CAS 389073-97-6

2-Ethyl-N-(5-((2-(indolin-1-yl)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)butanamide

CAS 389073-97-6C₁₈H₂₂N₄O₂S₂

1-(5-Bromo-2,3-dihydro-1H-indol-1-yl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone chemical structure, C13H12BrN3OS2, CAS 914353-88-1

1-(5-Bromo-2,3-dihydro-1H-indol-1-yl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone

CAS 914353-88-1C₁₃H₁₂BrN₃OS₂

N-(5-{[2-(2,3-Dihydro-1H-indol-1-yl)-2-oxoethyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-2-(N-methylmethanesulfonamido)acetamide chemical structure, C16H19N5O4S3, CAS 1226438-02-3

N-(5-{[2-(2,3-Dihydro-1H-indol-1-yl)-2-oxoethyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-2-(N-methylmethanesulfonamido)acetamide

CAS 1226438-02-3C₁₆H₁₉N₅O₄S₃