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Murcko scaffold

Ring system with 2 rings and 18 atoms

17 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 18
Chemicals: 17
With full pages: 3

Scaffold SMILES

O=C(Cn1ccccc1=O)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Cn1ccccc1=O)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

N-Benzyl-2-[3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1-yl]acetamide chemical structure, C15H12ClF3N2O2, CAS 744230-23-7

N-Benzyl-2-[3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1-yl]acetamide

CAS 744230-23-7C₁₅H₁₂ClF₃N₂O₂

2-[3-Chloro-2-oxo-5-(trifluoromethyl)-1,2-dihydropyridin-1-yl]-N-[(4-fluorophenyl)methyl]acetamide chemical structure, C15H11ClF4N2O2, CAS 876903-55-8

2-[3-Chloro-2-oxo-5-(trifluoromethyl)-1,2-dihydropyridin-1-yl]-N-[(4-fluorophenyl)methyl]acetamide

CAS 876903-55-8C₁₅H₁₁ClF₄N₂O₂

N-Benzyl-2-[3-cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]acetamide chemical structure, C18H19N3O3, CAS 862660-82-0

N-Benzyl-2-[3-cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]acetamide

CAS 862660-82-0C₁₈H₁₉N₃O₃

N-[1-(4-Fluorophenyl)ethyl]-2-[2-oxo-5-(trifluoromethyl)pyridin-1-yl]acetamide chemical structure, C16H14F4N2O2, CAS 851721-09-0

N-[1-(4-Fluorophenyl)ethyl]-2-[2-oxo-5-(trifluoromethyl)pyridin-1-yl]acetamide

CAS 851721-09-0C₁₆H₁₄F₄N₂O₂

N-[(4-Chlorophenyl)methyl]-2-(3-cyano-4,6-dimethyl-2-oxo-1,2-dihydropyridin-1-yl)acetamide chemical structure, C17H16ClN3O2, CAS 932338-31-3

N-[(4-Chlorophenyl)methyl]-2-(3-cyano-4,6-dimethyl-2-oxo-1,2-dihydropyridin-1-yl)acetamide

CAS 932338-31-3C₁₇H₁₆ClN₃O₂

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-[(4-fluorophenyl)methyl]acetamide chemical structure, C17H16FN3O2, CAS 941913-38-8

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-[(4-fluorophenyl)methyl]acetamide

CAS 941913-38-8C₁₇H₁₆FN₃O₂

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-methoxybenzyl)acetamide chemical structure, C18H19N3O3, CAS 932314-83-5

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-methoxybenzyl)acetamide

CAS 932314-83-5C₁₈H₁₉N₃O₃

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(2-methoxybenzyl)acetamide chemical structure, C18H19N3O3, CAS 932338-34-6

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(2-methoxybenzyl)acetamide

CAS 932338-34-6C₁₈H₁₉N₃O₃

N-[(4-Fluorophenyl)methyl]-2-(2-oxopyridin-1-yl)acetamide chemical structure, C14H13FN2O2, CAS 923200-65-1

N-[(4-Fluorophenyl)methyl]-2-(2-oxopyridin-1-yl)acetamide

CAS 923200-65-1C₁₄H₁₃FN₂O₂

N-(2-Chlorobenzyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide chemical structure, C17H16ClN3O2, CAS 932528-63-7

N-(2-Chlorobenzyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide

CAS 932528-63-7C₁₇H₁₆ClN₃O₂

2-(5-Amino-2-oxo-1,2-dihydropyridin-1-yl)-N-benzylacetamide chemical structure, C14H15N3O2, CAS 1038738-18-9

2-(5-Amino-2-oxo-1,2-dihydropyridin-1-yl)-N-benzylacetamide

CAS 1038738-18-9C₁₄H₁₅N₃O₂

1-(Benzylcarbamoyl-methyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid chemical structure, C15H14N2O4, CAS 1039898-52-6

1-(Benzylcarbamoyl-methyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid

CAS 1039898-52-6C₁₅H₁₄N₂O₄

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(2,3-dimethoxybenzyl)acetamide chemical structure, C19H21N3O4, CAS 1032004-96-8

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(2,3-dimethoxybenzyl)acetamide

CAS 1032004-96-8C₁₉H₂₁N₃O₄

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-(methylthio)benzyl)acetamide chemical structure, C18H19N3O2S, CAS 1032005-00-7

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-(methylthio)benzyl)acetamide

CAS 1032005-00-7C₁₈H₁₉N₃O₂S

2-(3-Amino-2-oxo-1,2-dihydropyridin-1-yl)-N-benzylacetamide chemical structure, C14H15N3O2, CAS 1457909-29-3

2-(3-Amino-2-oxo-1,2-dihydropyridin-1-yl)-N-benzylacetamide

CAS 1457909-29-3C₁₄H₁₅N₃O₂

N-(3,4-Dimethoxybenzyl)-2-(4-hydroxy-6-methyl-2-oxopyridin-1(2H)-yl)acetamide chemical structure, C17H20N2O5, CAS 1574288-51-9

N-(3,4-Dimethoxybenzyl)-2-(4-hydroxy-6-methyl-2-oxopyridin-1(2H)-yl)acetamide

CAS 1574288-51-9C₁₇H₂₀N₂O₅

1,2-Dihydro-6-methyl-2-oxo-1-[2-oxo-2-[(1-phenylethyl)amino]ethyl]-3-pyridinecarboxylic acid chemical structure, C17H18N2O4, CAS 1225617-76-4

1,2-Dihydro-6-methyl-2-oxo-1-[2-oxo-2-[(1-phenylethyl)amino]ethyl]-3-pyridinecarboxylic acid

CAS 1225617-76-4C₁₇H₁₈N₂O₄