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Murcko scaffold

Ring system with 4 rings and 25 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
9
With full pages
2
Scaffold SMILES

O=C(Nc1c2c(nn1-c1ccccc1)CSC2)C(=O)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1c2c(nn1-c1ccccc1)CSC2)C(=O)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

N-[2-(4-Methoxyphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-(4-methylpiperazin-1-yl)-2-oxoacetamide chemical structure, C19H23N5O3S, CAS 946332-04-3
N-[2-(4-Methoxyphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-(4-methylpiperazin-1-yl)-2-oxoacetamide
CAS 946332-04-3C19H23N5O3S
2-(4-Ethylpiperazin-1-yl)-N-[2-(4-methoxyphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-oxoacetamide chemical structure, C20H25N5O3S, CAS 899969-72-3
2-(4-Ethylpiperazin-1-yl)-N-[2-(4-methoxyphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-oxoacetamide
CAS 899969-72-3C20H25N5O3S
N-[2-(4-Fluorophenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-(4-methylpiperazin-1-yl)-2-oxoacetamide chemical structure, C18H20FN5O2S, CAS 946209-21-8
N-[2-(4-Fluorophenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-(4-methylpiperazin-1-yl)-2-oxoacetamide
CAS 946209-21-8C18H20FN5O2S
2-(4-Acetylpiperazin-1-yl)-N-[2-(4-fluorophenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-oxoacetamide chemical structure, C19H20FN5O3S, CAS 899969-90-5
2-(4-Acetylpiperazin-1-yl)-N-[2-(4-fluorophenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-oxoacetamide
CAS 899969-90-5C19H20FN5O3S
N-[2-(4-Chlorophenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-(4-methylpiperazin-1-yl)-2-oxoacetamide chemical structure, C18H20ClN5O2S, CAS 946332-28-1
N-[2-(4-Chlorophenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-(4-methylpiperazin-1-yl)-2-oxoacetamide
CAS 946332-28-1C18H20ClN5O2S
N-[2-(3-Chlorophenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-(4-methylpiperazin-1-yl)-2-oxoacetamide chemical structure, C18H20ClN5O2S, CAS 946354-28-5
N-[2-(3-Chlorophenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-(4-methylpiperazin-1-yl)-2-oxoacetamide
CAS 946354-28-5C18H20ClN5O2S
2-(4-Methylpiperazin-1-yl)-2-oxo-N-(2-phenyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)acetamide chemical structure, C18H21N5O2S, CAS 899969-54-1
2-(4-Methylpiperazin-1-yl)-2-oxo-N-(2-phenyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)acetamide
CAS 899969-54-1C18H21N5O2S
2-(4-Acetylpiperazin-1-yl)-2-oxo-N-(2-phenyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)acetamide chemical structure, C19H21N5O3S, CAS 941884-04-4
2-(4-Acetylpiperazin-1-yl)-2-oxo-N-(2-phenyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)acetamide
CAS 941884-04-4C19H21N5O3S
2-(4-Acetylpiperazin-1-yl)-N-(2-(4-chlorophenyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-oxoacetamide chemical structure, C19H20ClN5O3S, CAS 946209-33-2
2-(4-Acetylpiperazin-1-yl)-N-(2-(4-chlorophenyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-oxoacetamide
CAS 946209-33-2C19H20ClN5O3S