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Murcko scaffold

Ring system with 4 rings and 26 atoms

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
8
With full pages
4
Scaffold SMILES

c1ccc(Nc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Nc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

2-((5-Chloro-2-((2-methoxy-4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide chemical structure, C23H25ClN6O3, CAS 761437-28-9
2-((5-Chloro-2-((2-methoxy-4-morpholin-4-ylphenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
CAS 761437-28-9C23H25ClN6O3
N4-(2-carboxyphenyl)-N2-(4-morpholinophenyl)pyrimidine-2,4-diamine chemical structure, C21H21N5O3, CAS 929007-68-1
N4-(2-carboxyphenyl)-N2-(4-morpholinophenyl)pyrimidine-2,4-diamine
CAS 929007-68-1C21H21N5O3
N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide chemical structure, C22H25ClN6O4S, CAS 1191911-27-9
N-(2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide
CAS 1191911-27-9C22H25ClN6O4S
N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide chemical structure, C22H25FN6O4S, CAS 1191911-26-8
N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide
CAS 1191911-26-8C22H25FN6O4S
2-((5-Chloro-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide chemical structure, C22H23ClN6O2, CAS 1042432-58-5
2-((5-Chloro-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
CAS 1042432-58-5C22H23ClN6O2
Nvp-tac544 chemical structure, C22H25BrN6O4S, CAS 761436-62-8
Nvp-tac544
CAS 761436-62-8C22H25BrN6O4S
CZC-25146 hydrochloride chemical structure, C22H26ClFN6O4S, CAS 1330003-04-7
CZC-25146 hydrochloride
CAS 1330003-04-7C22H26ClFN6O4S
CZC 54252 hydrochloride chemical structure, C22H26Cl2N6O4S, CAS 1784253-05-9
CZC 54252 hydrochloride
CAS 1784253-05-9C22H26Cl2N6O4S