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Murcko scaffold

Ring system with 4 rings and 26 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
9
With full pages
3
Scaffold SMILES

c1ccc(Nc2ncnc(CN3CCN(c4ccccn4)CC3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Nc2ncnc(CN3CCN(c4ccccn4)CC3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

2-N-(4-Chlorophenyl)-6-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1,3,5-triazine-2,4-diamine chemical structure, C19H21ClN8, CAS 827002-46-0
2-N-(4-Chlorophenyl)-6-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1,3,5-triazine-2,4-diamine
CAS 827002-46-0C19H21ClN8
N2-(4-fluorophenyl)-6-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine chemical structure, C19H21FN8, CAS 727680-28-6
N2-(4-fluorophenyl)-6-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine
CAS 727680-28-6C19H21FN8
N-(2-Methylphenyl)-6-{[4-(2-pyridinyl)-1-piperazinyl]methyl}-1,3,5-triazine-2,4-diamine chemical structure, C20H24N8, CAS 827002-31-3
N-(2-Methylphenyl)-6-{[4-(2-pyridinyl)-1-piperazinyl]methyl}-1,3,5-triazine-2,4-diamine
CAS 827002-31-3C20H24N8
N-(2-Methoxyphenyl)-6-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}-1,3,5-triazine-2,4-diamine chemical structure, C20H24N8O, CAS 775289-24-2
N-(2-Methoxyphenyl)-6-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}-1,3,5-triazine-2,4-diamine
CAS 775289-24-2C20H24N8O
N-(4-Methoxyphenyl)-6-{[4-(2-pyridinyl)-1-piperazinyl]methyl}-1,3,5-triazine-2,4-diamine chemical structure, C20H24N8O, CAS 835894-42-3
N-(4-Methoxyphenyl)-6-{[4-(2-pyridinyl)-1-piperazinyl]methyl}-1,3,5-triazine-2,4-diamine
CAS 835894-42-3C20H24N8O
N-(4-Amino-6-{[4-(2-pyridyl)piperazino]methyl}-1,3,5-triazin-2-yl)-N-(2-methoxy-5-methylphenyl)amine chemical structure, C21H26N8O, CAS 827001-85-4
N-(4-Amino-6-{[4-(2-pyridyl)piperazino]methyl}-1,3,5-triazin-2-yl)-N-(2-methoxy-5-methylphenyl)amine
CAS 827001-85-4C21H26N8O
{4-Amino-6-[(4-(2-pyridyl)piperazinyl)methyl](1,3,5-triazin-2-yl)}phenylamine chemical structure, C19H22N8, CAS 885902-87-4
{4-Amino-6-[(4-(2-pyridyl)piperazinyl)methyl](1,3,5-triazin-2-yl)}phenylamine
CAS 885902-87-4C19H22N8
N-(4-Amino-6-{[4-(2-pyridyl)piperazino]methyl}-1,3,5-triazin-2-yl)-N-(3-chlorophenyl)amine chemical structure, C19H21ClN8, CAS 827003-05-4
N-(4-Amino-6-{[4-(2-pyridyl)piperazino]methyl}-1,3,5-triazin-2-yl)-N-(3-chlorophenyl)amine
CAS 827003-05-4C19H21ClN8
N-(3-Methoxyphenyl)-6-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}-1,3,5-triazine-2,4-diamine chemical structure, C20H24N8O, CAS 827003-00-9
N-(3-Methoxyphenyl)-6-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}-1,3,5-triazine-2,4-diamine
CAS 827003-00-9C20H24N8O