Murcko scaffold
Ring system with 4 rings and 25 atoms
21 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 21
- With full pages
- 3
Scaffold SMILES
O=C(c1ccccc1)N1CCN(c2cccc(-n3cccn3)c2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 21 of 21 chemicals
![(2-Chloro-4,5-difluorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C22H20ClF2N5O3, CAS 378765-26-5](/s/SRZZCVVJQQEVTK-UHFFFAOYSA-N.svg)
(2-Chloro-4,5-difluorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 378765-26-5C22H20ClF2N5O3
![(4-Bromophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C22H22BrN5O3, CAS 380566-94-9](/s/XXUGWPRWESQXRG-UHFFFAOYSA-N.svg)
(4-Bromophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 380566-94-9C22H22BrN5O3
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(3-methylphenyl)methanone chemical structure, C23H25N5O3, CAS 381713-30-0](/s/ZSIKQRIHPPWZTO-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(3-methylphenyl)methanone
CAS 381713-30-0C23H25N5O3
![(3-Chlorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C22H22ClN5O3, CAS 378752-01-3](/s/UGPUNMJZMGHUQG-UHFFFAOYSA-N.svg)
(3-Chlorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 378752-01-3C22H22ClN5O3
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(2-fluorophenyl)methanone chemical structure, C22H22FN5O3, CAS 401631-84-3](/s/AVIDLHQJALCDQU-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(2-fluorophenyl)methanone
CAS 401631-84-3C22H22FN5O3
![(4-Chlorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C22H22ClN5O3, CAS 430448-76-3](/s/RRVBWAQSYSNIMV-UHFFFAOYSA-N.svg)
(4-Chlorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 430448-76-3C22H22ClN5O3
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-fluorophenyl)methanone chemical structure, C22H22FN5O3, CAS 430450-49-0](/s/OYDXXFSCHWSMNN-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-fluorophenyl)methanone
CAS 430450-49-0C22H22FN5O3
![(2-Chlorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C22H22ClN5O3, CAS 441782-87-2](/s/UTHTYMGCHDCTLL-UHFFFAOYSA-N.svg)
(2-Chlorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 441782-87-2C22H22ClN5O3
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-phenylmethanone chemical structure, C22H23N5O3, CAS 430454-99-2](/s/VASRYFLLGQNRIT-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-phenylmethanone
CAS 430454-99-2C22H23N5O3
![(2-Bromophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C22H22BrN5O3, CAS 430448-14-9](/s/CGCUAYRHTFHFJD-UHFFFAOYSA-N.svg)
(2-Bromophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 430448-14-9C22H22BrN5O3
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-methylphenyl)methanone chemical structure, C23H25N5O3, CAS 441782-86-1](/s/AVEANYYBJDJHKI-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-methylphenyl)methanone
CAS 441782-86-1C23H25N5O3
![1-(4-tert-Butylbenzoyl)-4-[3-(3,5-dimethyl-1H-pyrazol-1-yl)-4-nitrophenyl]piperazine chemical structure, C26H31N5O3, CAS 432501-40-1](/s/RDRFKINNPACGJA-UHFFFAOYSA-N.svg)
1-(4-tert-Butylbenzoyl)-4-[3-(3,5-dimethyl-1H-pyrazol-1-yl)-4-nitrophenyl]piperazine
CAS 432501-40-1C26H31N5O3
![1-(3-Bromobenzoyl)-4-[3-(3,5-dimethyl-1H-pyrazol-1-yl)-4-nitrophenyl]piperazine chemical structure, C22H22BrN5O3, CAS 432503-23-6](/s/XKJUEJLUOUOXBT-UHFFFAOYSA-N.svg)
1-(3-Bromobenzoyl)-4-[3-(3,5-dimethyl-1H-pyrazol-1-yl)-4-nitrophenyl]piperazine
CAS 432503-23-6C22H22BrN5O3
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-ethoxyphenyl)methanone chemical structure, C24H27N5O4, CAS 432532-33-7](/s/QUZGUKAJFXGBMT-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-ethoxyphenyl)methanone
CAS 432532-33-7C24H27N5O4
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(2-methylphenyl)methanone chemical structure, C23H25N5O3, CAS 433235-91-7](/s/GLOSBYOJPSLHJI-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(2-methylphenyl)methanone
CAS 433235-91-7C23H25N5O3
![1-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-nitrophenyl]-4-(3-fluorobenzoyl)piperazine chemical structure, C22H22FN5O3, CAS 433238-92-7](/s/YDXLMCQTHQGLGZ-UHFFFAOYSA-N.svg)
1-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-nitrophenyl]-4-(3-fluorobenzoyl)piperazine
CAS 433238-92-7C22H22FN5O3
![(3,4-Dichlorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C22H21Cl2N5O3, CAS 524034-64-8](/s/COCOIAQFBMZYAY-UHFFFAOYSA-N.svg)
(3,4-Dichlorophenyl)-[4-[3-(3,5-dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]methanone
CAS 524034-64-8C22H21Cl2N5O3
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-ethylphenyl)methanone chemical structure, C24H27N5O3, CAS 591736-99-1](/s/JLTDYQRSMBLLFR-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-ethylphenyl)methanone
CAS 591736-99-1C24H27N5O3
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(3-propan-2-yloxyphenyl)methanone chemical structure, C25H29N5O4, CAS 591765-32-1](/s/GQZBOCMRDXMFDQ-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(3-propan-2-yloxyphenyl)methanone
CAS 591765-32-1C25H29N5O4
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-propan-2-yloxyphenyl)methanone chemical structure, C25H29N5O4, CAS 956185-04-9](/s/KYRWWACZRZTNMG-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(4-propan-2-yloxyphenyl)methanone
CAS 956185-04-9C25H29N5O4
![[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(2-methoxy-3-methylphenyl)methanone chemical structure, C24H27N5O4, CAS 894526-23-9](/s/ILPCLPQNMQAFGC-UHFFFAOYSA-N.svg)
[4-[3-(3,5-Dimethylpyrazol-1-yl)-4-nitrophenyl]piperazin-1-yl]-(2-methoxy-3-methylphenyl)methanone
CAS 894526-23-9C24H27N5O4
Related scaffolds
Same ring framework with different atoms or bond orders
