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Murcko scaffold

Ring system with 3 rings and 25 atoms

62 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
62
With full pages
3
Scaffold SMILES

O=C(C=Cc1ccccc1OCc1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1OCc1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

(2E)-N-[4-(Acetylamino)phenyl]-3-{2-[(2-chlorobenzyl)oxy]phenyl}-2-cyanoprop-2-enamide chemical structure, C25H20ClN3O3, CAS 380475-47-8
(2E)-N-[4-(Acetylamino)phenyl]-3-{2-[(2-chlorobenzyl)oxy]phenyl}-2-cyanoprop-2-enamide
CAS 380475-47-8C25H20ClN3O3
Methyl 2-[[(E)-3-[2-[(2-chlorophenyl)methoxy]phenyl]-2-cyanoprop-2-enoyl]amino]benzoate chemical structure, C25H19ClN2O4, CAS 380477-56-5
Methyl 2-[[(E)-3-[2-[(2-chlorophenyl)methoxy]phenyl]-2-cyanoprop-2-enoyl]amino]benzoate
CAS 380477-56-5C25H19ClN2O4
(Z)-2-Cyano-3-[2-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl]-N-[2-(trifluoromethyl)phenyl]prop-2-enamide chemical structure, C25H17Cl2F3N2O3, CAS 634594-89-1
(Z)-2-Cyano-3-[2-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl]-N-[2-(trifluoromethyl)phenyl]prop-2-enamide
CAS 634594-89-1C25H17Cl2F3N2O3
(E)-3-[5-Bromo-2-[(2-cyanophenyl)methoxy]phenyl]-2-cyano-N-(4-ethylphenyl)prop-2-enamide chemical structure, C26H20BrN3O2, CAS 340301-45-3
(E)-3-[5-Bromo-2-[(2-cyanophenyl)methoxy]phenyl]-2-cyano-N-(4-ethylphenyl)prop-2-enamide
CAS 340301-45-3C26H20BrN3O2
Methyl 4-[[2-[(E)-3-(4-chloro-2-methoxy-5-methylanilino)-2-cyano-3-oxoprop-1-enyl]phenoxy]methyl]benzoate chemical structure, C27H23ClN2O5, CAS 749215-06-3
Methyl 4-[[2-[(E)-3-(4-chloro-2-methoxy-5-methylanilino)-2-cyano-3-oxoprop-1-enyl]phenoxy]methyl]benzoate
CAS 749215-06-3C27H23ClN2O5
(E)-3-[2-[(2-Chlorophenyl)methoxy]phenyl]-2-cyano-N-(3,5-dichlorophenyl)prop-2-enamide chemical structure, C23H15Cl3N2O2, CAS 380476-16-4
(E)-3-[2-[(2-Chlorophenyl)methoxy]phenyl]-2-cyano-N-(3,5-dichlorophenyl)prop-2-enamide
CAS 380476-16-4C23H15Cl3N2O2
(E)-3-[2-[(2-Chlorophenyl)methoxy]phenyl]-2-cyano-N-(2,5-dimethylphenyl)prop-2-enamide chemical structure, C25H21ClN2O2, CAS 380477-45-2
(E)-3-[2-[(2-Chlorophenyl)methoxy]phenyl]-2-cyano-N-(2,5-dimethylphenyl)prop-2-enamide
CAS 380477-45-2C25H21ClN2O2
2-Cyano-3-{2-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl}-N-[3-(trifluoromethyl)phenyl]prop-2-enamide chemical structure, C25H17Cl2F3N2O3, CAS 380478-33-1
2-Cyano-3-{2-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl}-N-[3-(trifluoromethyl)phenyl]prop-2-enamide
CAS 380478-33-1C25H17Cl2F3N2O3
3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyano-N-[3-(trifluoromethyl)phenyl]prop-2-enamide chemical structure, C25H18BrF3N2O3, CAS 380561-68-2
3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyano-N-[3-(trifluoromethyl)phenyl]prop-2-enamide
CAS 380561-68-2C25H18BrF3N2O3
3-[[(E)-3-[2-[(2-Chlorophenyl)methoxy]phenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid chemical structure, C24H17ClN2O4, CAS 380563-10-0
3-[[(E)-3-[2-[(2-Chlorophenyl)methoxy]phenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid
CAS 380563-10-0C24H17ClN2O4
(E)-2-Cyano-3-[2-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl]-N-(4-methoxyphenyl)prop-2-enamide chemical structure, C25H20Cl2N2O4, CAS 522604-19-9
(E)-2-Cyano-3-[2-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl]-N-(4-methoxyphenyl)prop-2-enamide
CAS 522604-19-9C25H20Cl2N2O4
Methyl 4-[[2-[(E)-2-cyano-3-[4-(difluoromethylsulfanyl)anilino]-3-oxoprop-1-enyl]phenoxy]methyl]benzoate chemical structure, C26H20F2N2O4S, CAS 737818-60-9
Methyl 4-[[2-[(E)-2-cyano-3-[4-(difluoromethylsulfanyl)anilino]-3-oxoprop-1-enyl]phenoxy]methyl]benzoate
CAS 737818-60-9C26H20F2N2O4S
(E)-3-(5-Bromo-2-phenylmethoxyphenyl)-2-cyano-N-(4-methoxyphenyl)prop-2-enamide chemical structure, C24H19BrN2O3, CAS 359026-51-0
(E)-3-(5-Bromo-2-phenylmethoxyphenyl)-2-cyano-N-(4-methoxyphenyl)prop-2-enamide
CAS 359026-51-0C24H19BrN2O3
2-Cyano-3-{2-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl}-N-(3,4-dimethylphenyl)prop-2-enamide chemical structure, C26H22Cl2N2O3, CAS 522656-83-3
2-Cyano-3-{2-[(2,4-dichlorophenyl)methoxy]-3-methoxyphenyl}-N-(3,4-dimethylphenyl)prop-2-enamide
CAS 522656-83-3C26H22Cl2N2O3
3-(3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyanoprop-2-enamido)benzoic acid chemical structure, C25H19BrN2O5, CAS 522656-86-6
3-(3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyanoprop-2-enamido)benzoic acid
CAS 522656-86-6C25H19BrN2O5
3-[[(Z)-3-[2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid chemical structure, C25H19BrN2O5
3-[[(Z)-3-[2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid
C25H19BrN2O5
(Z)-3-[2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl]-2-cyano-N-(3,5-dichlorophenyl)prop-2-enamide chemical structure, C24H17BrCl2N2O3, CAS 522656-90-2
(Z)-3-[2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl]-2-cyano-N-(3,5-dichlorophenyl)prop-2-enamide
CAS 522656-90-2C24H17BrCl2N2O3
3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyano-N-(4-fluorophenyl)prop-2-enamide chemical structure, C24H18BrFN2O3, CAS 522656-96-8
3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyano-N-(4-fluorophenyl)prop-2-enamide
CAS 522656-96-8C24H18BrFN2O3
3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyano-N-(3,4-dimethylphenyl)prop-2-enamide chemical structure, C26H23BrN2O3, CAS 522656-98-0
3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyano-N-(3,4-dimethylphenyl)prop-2-enamide
CAS 522656-98-0C26H23BrN2O3
(Z)-3-[2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl]-2-cyano-N-(2-fluorophenyl)prop-2-enamide chemical structure, C24H18BrFN2O3, CAS 522656-99-1
(Z)-3-[2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl]-2-cyano-N-(2-fluorophenyl)prop-2-enamide
CAS 522656-99-1C24H18BrFN2O3
3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyano-N-(2,4,6-trimethylphenyl)prop-2-enamide chemical structure, C27H25BrN2O3, CAS 522657-27-8
3-{2-[(4-Bromophenyl)methoxy]-3-methoxyphenyl}-2-cyano-N-(2,4,6-trimethylphenyl)prop-2-enamide
CAS 522657-27-8C27H25BrN2O3
Methyl 4-[[2-[(E)-2-cyano-3-oxo-3-[3-(trifluoromethyl)anilino]prop-1-enyl]phenoxy]methyl]benzoate chemical structure, C26H19F3N2O4, CAS 750618-62-3
Methyl 4-[[2-[(E)-2-cyano-3-oxo-3-[3-(trifluoromethyl)anilino]prop-1-enyl]phenoxy]methyl]benzoate
CAS 750618-62-3C26H19F3N2O4
Methyl 4-[(2-{2-cyano-2-[(2,6-dimethylphenyl)carbamoyl]eth-1-en-1-yl}phenoxy)methyl]benzoate chemical structure, C27H24N2O4, CAS 565194-78-7
Methyl 4-[(2-{2-cyano-2-[(2,6-dimethylphenyl)carbamoyl]eth-1-en-1-yl}phenoxy)methyl]benzoate
CAS 565194-78-7C27H24N2O4
Methyl 4-[(2-{2-cyano-2-[(2,4-dimethylphenyl)carbamoyl]eth-1-en-1-yl}phenoxy)methyl]benzoate chemical structure, C27H24N2O4, CAS 1164503-67-6
Methyl 4-[(2-{2-cyano-2-[(2,4-dimethylphenyl)carbamoyl]eth-1-en-1-yl}phenoxy)methyl]benzoate
CAS 1164503-67-6C27H24N2O4