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Murcko scaffold

Ring system with 4 rings and 29 atoms

45 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
45
With full pages
1
Scaffold SMILES

O=C(CSc1cn(CC(=O)N2CCCCC2)c2ccccc12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1cn(CC(=O)N2CCCCC2)c2ccccc12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 45 of 45 chemicals

2-((1-(2-(4-Methylpiperidin-1-yl)-2-oxoethyl)-1H-indol-3-yl)thio)-N-phenylacetamide chemical structure, C24H27N3O2S, CAS 878055-56-2
2-((1-(2-(4-Methylpiperidin-1-yl)-2-oxoethyl)-1H-indol-3-yl)thio)-N-phenylacetamide
CAS 878055-56-2C24H27N3O2S
N-(2-Fluorophenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide chemical structure, C23H24FN3O2S, CAS 878052-80-3
N-(2-Fluorophenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 878052-80-3C23H24FN3O2S
N-(5-Chloro-2-methoxyphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide chemical structure, C24H26ClN3O3S, CAS 878052-96-1
N-(5-Chloro-2-methoxyphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 878052-96-1C24H26ClN3O3S
N-(2,4-Dimethoxyphenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C25H29N3O4S, CAS 878053-05-5
N-(2,4-Dimethoxyphenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 878053-05-5C25H29N3O4S
2-({1-[2-Oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)-N-[4-(trifluoromethyl)phenyl]acetamide chemical structure, C24H24F3N3O2S, CAS 878053-14-6
2-({1-[2-Oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)-N-[4-(trifluoromethyl)phenyl]acetamide
CAS 878053-14-6C24H24F3N3O2S
Methyl 4-[({[1-(2-oxo-2-piperidin-1-ylethyl)-1H-indol-3-yl]thio}acetyl)amino]benzoate chemical structure, C25H27N3O4S, CAS 878053-19-1
Methyl 4-[({[1-(2-oxo-2-piperidin-1-ylethyl)-1H-indol-3-yl]thio}acetyl)amino]benzoate
CAS 878053-19-1C25H27N3O4S
N-(4-Acetylphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide chemical structure, C25H27N3O3S, CAS 878053-20-4
N-(4-Acetylphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 878053-20-4C25H27N3O3S
2-((1-(2-Oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)-N-(m-tolyl)acetamide chemical structure, C24H27N3O2S, CAS 878052-65-4
2-((1-(2-Oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)-N-(m-tolyl)acetamide
CAS 878052-65-4C24H27N3O2S
N-(4-Methylphenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C24H27N3O2S, CAS 878052-67-6
N-(4-Methylphenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 878052-67-6C24H27N3O2S
N-(2,3-Dimethylphenyl)-2-{[1-(2-oxo-2-piperidin-1-ylethyl)-1H-indol-3-yl]thio}acetamide chemical structure, C25H29N3O2S, CAS 878052-70-1
N-(2,3-Dimethylphenyl)-2-{[1-(2-oxo-2-piperidin-1-ylethyl)-1H-indol-3-yl]thio}acetamide
CAS 878052-70-1C25H29N3O2S
N-(2,4-Dimethylphenyl)-2-{[1-(2-oxo-2-piperidin-1-ylethyl)-1H-indol-3-yl]thio}acetamide chemical structure, C25H29N3O2S, CAS 878052-72-3
N-(2,4-Dimethylphenyl)-2-{[1-(2-oxo-2-piperidin-1-ylethyl)-1H-indol-3-yl]thio}acetamide
CAS 878052-72-3C25H29N3O2S
N-(4-Butylphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide chemical structure, C27H33N3O2S, CAS 878052-78-9
N-(4-Butylphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 878052-78-9C27H33N3O2S
N-(4-Fluorophenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide chemical structure, C23H24FN3O2S, CAS 878052-84-7
N-(4-Fluorophenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 878052-84-7C23H24FN3O2S
N-(4-Chlorophenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C23H24ClN3O2S, CAS 878052-88-1
N-(4-Chlorophenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 878052-88-1C23H24ClN3O2S
N-(3-Chloro-4-methylphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide chemical structure, C24H26ClN3O2S, CAS 878052-94-9
N-(3-Chloro-4-methylphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 878052-94-9C24H26ClN3O2S
N-(3-Methoxyphenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C24H27N3O3S, CAS 878052-99-4
N-(3-Methoxyphenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 878052-99-4C24H27N3O3S
N-(4-Methoxyphenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C24H27N3O3S, CAS 878053-01-1
N-(4-Methoxyphenyl)-2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 878053-01-1C24H27N3O3S
N-(4-Ethoxyphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide chemical structure, C25H29N3O3S, CAS 878053-03-3
N-(4-Ethoxyphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 878053-03-3C25H29N3O3S
N-(3,4-Dimethoxyphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide chemical structure, C25H29N3O4S, CAS 878053-08-8
N-(3,4-Dimethoxyphenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 878053-08-8C25H29N3O4S
2-({1-[2-Oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C24H24F3N3O2S, CAS 878053-13-5
2-({1-[2-Oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 878053-13-5C24H24F3N3O2S
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide chemical structure, C24H23ClF3N3O2S, CAS 878053-15-7
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((1-(2-oxo-2-(piperidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 878053-15-7C24H23ClF3N3O2S
Ethyl 4-[2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamido]benzoate chemical structure, C26H29N3O4S, CAS 878053-18-0
Ethyl 4-[2-({1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamido]benzoate
CAS 878053-18-0C26H29N3O4S
4-[({[1-(2-Oxo-2-piperidin-1-ylethyl)-1H-indol-3-yl]thio}acetyl)amino]benzamide chemical structure, C24H26N4O3S, CAS 878053-50-0
4-[({[1-(2-Oxo-2-piperidin-1-ylethyl)-1H-indol-3-yl]thio}acetyl)amino]benzamide
CAS 878053-50-0C24H26N4O3S
2-((1-(2-(4-Methylpiperidin-1-yl)-2-oxoethyl)-1H-indol-3-yl)thio)-N-(o-tolyl)acetamide chemical structure, C25H29N3O2S, CAS 878055-60-8
2-((1-(2-(4-Methylpiperidin-1-yl)-2-oxoethyl)-1H-indol-3-yl)thio)-N-(o-tolyl)acetamide
CAS 878055-60-8C25H29N3O2S