Murcko scaffold
Ring system with 2 rings and 15 atoms
53 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 15
- Chemicals
- 53
- With full pages
- 5
Scaffold SMILES
O=S(=O)(c1ccccc1)N1CCSCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 53 chemicals
3-(Thiomorpholinosulfonyl)benzoic acid
CAS 799262-54-7C11H13NO4S2
![4-[(4-Fluorophenyl)sulfonyl]thiomorpholine chemical structure, C10H12FNO2S2, CAS 312537-82-9](/s/OKUUURQVMYFVAH-UHFFFAOYSA-N.svg)
4-[(4-Fluorophenyl)sulfonyl]thiomorpholine
CAS 312537-82-9C10H12FNO2S2
4-(4-Methoxy-benzenesulfonyl)-thiomorpholine
CAS 352446-43-6C11H15NO3S2
Methyl 2-(4,5-dimethoxy-2-(thiomorpholinosulfonyl)phenyl)acetate
CAS 886499-16-7C15H21NO6S2
4-((3,4-Dichlorophenyl)sulfonyl)thiomorpholine
CAS 294211-99-7C10H11Cl2NO2S2
4-(4-Chloro-benzenesulfonyl)-thiomorpholine
CAS 450354-67-3C10H12ClNO2S2
![4-[[3,5-Bis(trifluoromethyl)phenyl]sulfonyl]thiomorpholine chemical structure, C12H11F6NO2S2, CAS 663884-53-5](/s/XQNCHVQLPAORJA-UHFFFAOYSA-N.svg)
4-[[3,5-Bis(trifluoromethyl)phenyl]sulfonyl]thiomorpholine
CAS 663884-53-5C12H11F6NO2S2
3-Bromo-5-thiomorpholin-4-ylsulfonylbenzoic acid
CAS 522652-13-7C11H12BrNO4S2
4-((2-Chlorophenyl)sulfonyl)thiomorpholine
CAS 494778-14-2C10H12ClNO2S2
4-((2,4-Dichlorophenyl)sulfonyl)thiomorpholine
CAS 1022332-86-0C10H11Cl2NO2S2
4-((2,4-Difluorophenyl)sulfonyl)thiomorpholine
CAS 1022698-96-9C10H11F2NO2S2
4-((3-Chlorophenyl)sulfonyl)thiomorpholine
CAS 1023142-21-3C10H12ClNO2S2
![4-[(2-Bromophenyl)sulfonyl]thiomorpholine chemical structure, C10H12BrNO2S2, CAS 494778-16-4](/s/FWWGTQDCMHUROG-UHFFFAOYSA-N.svg)
4-[(2-Bromophenyl)sulfonyl]thiomorpholine
CAS 494778-16-4C10H12BrNO2S2
4-((3-Fluorophenyl)sulfonyl)thiomorpholine
CAS 1022847-46-6C10H12FNO2S2
4-Tosylthiomorpholine
CAS 91329-86-1C11H15NO2S2
![(3S)-4-{[4-(But-2-ynyloxy)phenyl]sulfonyl}-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide chemical structure, C17H22N2O5S2, CAS 287403-39-8](/s/CVZIHNYAZLXRRS-HNNXBMFYSA-N.svg)
(3S)-4-{[4-(But-2-ynyloxy)phenyl]sulfonyl}-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
CAS 287403-39-8C17H22N2O5S2
4-Methoxy-3-(4-thiomorpholinylsulfonyl)benzoic acid
CAS 299181-39-8C12H15NO5S2
4-((2-Fluorophenyl)sulfonyl)thiomorpholine
CAS 913481-94-4C10H12FNO2S2
![4-[(4-Methoxyphenyl)sulfonyl]-3-thiomorpholinecarboxylic acid chemical structure, C12H15NO5S2, CAS 253195-13-0](/s/RFTUHYGDLMRPJB-UHFFFAOYSA-N.svg)
4-[(4-Methoxyphenyl)sulfonyl]-3-thiomorpholinecarboxylic acid
CAS 253195-13-0C12H15NO5S2
Apratastat
CAS 287405-51-0C17H22N2O6S2
4-(3-Bromo-benzenesulfonyl)-thiomorpholine
CAS 850349-32-5C10H12BrNO2S2
2-(Thiomorpoline-4-sulfonyl)-benzoic acid methyl ester
CAS 902137-96-6C12H15NO4S2
4-(4-Bromo-2-chloro-benzenesulfonyl)-thiomorpholine
CAS 902137-97-7C10H11BrClNO2S2
![1-[4-(Thiomorpholine-4-sulfonyl)-phenyl]-ethanone chemical structure, C12H15NO3S2, CAS 902137-95-5](/s/MHKYDSXPPIQXFY-UHFFFAOYSA-N.svg)
1-[4-(Thiomorpholine-4-sulfonyl)-phenyl]-ethanone
CAS 902137-95-5C12H15NO3S2
- 2-Chloro-5-(4-thiomorpholinylsulfonyl)benzoic acid494839-71-3C11H12ClNO4S2
- 2-(Thiomorpholine-4-sulfonyl)benzonitrile918812-56-3C11H12N2O2S2
- 4-((3,4-Difluorophenyl)sulfonyl)thiomorpholine1177671-26-9C10H11F2NO2S2
- 3-(Thiomorpholinosulfonyl)benzonitrile1042632-25-6C11H12N2O2S2
- 2,4-Dichloro-5-(thiomorpholinosulfonyl)benzoic acid352673-29-1C11H11Cl2NO4S2
- (4-(Thiomorpholinosulfonyl)phenyl)boronic acid871329-69-0C10H14BNO4S2
- 4-((2-Bromo-4-methylphenyl)sulfonyl)thiomorpholine1178285-38-5C11H14BrNO2S2
- 4-[(4-Bromo-2,6-dichlorophenyl)sulfonyl]thiomorpholine1183446-87-8C10H10BrCl2NO2S2
- 4-(3-Fluoro-4-methoxybenzenesulfonyl)thiomorpholine2322224-36-0C11H14FNO3S2
- 4-(Thiomorpholine-4-sulfonyl)benzene-1-sulfonamide55657-47-1C10H14N2O4S3
- 4-((2,5-Dichlorophenyl)sulfonyl)thiomorpholine2326057-51-4C10H11Cl2NO2S2
- 4-((3-Chloro-4-fluorophenyl)sulfonyl)thiomorpholine2329597-30-8C10H11ClFNO2S2
- 4-((4-(Bromomethyl)phenyl)sulfonyl)thiomorpholine1468836-61-4C11H14BrNO2S2
- 4-((2-(Chloromethyl)phenyl)sulfonyl)thiomorpholine1485687-81-7C11H14ClNO2S2
- 4-((3-(Chloromethyl)phenyl)sulfonyl)thiomorpholine1492540-54-1C11H14ClNO2S2
- 4-((4-(Chloromethyl)phenyl)sulfonyl)thiomorpholine1479781-15-1C11H14ClNO2S2
- 4-[(4-Methoxy-2,6-dimethylphenyl)sulfonyl]-3-thiomorpholinemethanol947729-89-7C14H21NO4S2
- (3R)-4-(2,4-Difluorobenzene-1-sulfonyl)thiomorpholine-3-carboxylic acid821800-13-9C11H11F2NO4S2
- (3R)-4-(3-Fluorobenzene-1-sulfonyl)thiomorpholine-3-carboxylic acid821800-12-8C11H12FNO4S2
- (3R)-4-(2-Fluorobenzene-1-sulfonyl)thiomorpholine-3-carboxylic acid821800-11-7C11H12FNO4S2
- 2-(4,5-Dimethoxy-2-(thiomorpholin-4-ylsulfonyl)phenyl)acetic acid1797096-12-8C14H19NO6S2
- 4-(4-Bromo-2-fluorophenylsulfonyl)thiomorpholine1771023-89-2C10H11BrFNO2S2
- 4-(5-Fluoro-2-methoxybenzenesulfonyl)thiomorpholine2327477-72-3C11H14FNO3S2
- 4-(3,5-Difluorobenzenesulfonyl)thiomorpholine2327064-41-3C10H11F2NO2S2
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(Cc2ccccc2)cc1952 chemicals
c1ccc(Oc2ccccc2)cc1933 chemicals
O=C(c1ccccc1)c1ccccc1537 chemicals
c1ccc(Nc2ccccc2)cc1395 chemicals
c1ccc(CN2CCCCC2)cc1283 chemicals
c1ccc(CN2CCNCC2)cc1267 chemicals
O=S(=O)(c1ccccc1)N1CCCCC1266 chemicals
c1ccc(Oc2ccccn2)cc1238 chemicals
c1ccc(Sc2ccccc2)cc1195 chemicals
O=S(=O)(c1ccccc1)N1CCNCC1195 chemicals
c1ccc(OC2CCCCO2)cc1164 chemicals
O=C(c1ccccc1)N1CCCCC1164 chemicals