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Murcko scaffold

Ring system with 4 rings and 24 atoms

17 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 17
With full pages: 2

Scaffold SMILES

O=c1oc2ccccc2cc1-c1csc(C=Cc2ccccc2)n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1oc2ccccc2cc1-c1csc(C=Cc2ccccc2)n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

(Z)-2-[4-(6-Bromo-2-oxochromen-3-yl)-1,3-thiazol-2-yl]-3-(4-methylphenyl)prop-2-enenitrile chemical structure, C22H13BrN2O2S, CAS 5309-76-2

(Z)-2-[4-(6-Bromo-2-oxochromen-3-yl)-1,3-thiazol-2-yl]-3-(4-methylphenyl)prop-2-enenitrile

CAS 5309-76-2C₂₂H₁₃BrN₂O₂S

(E)-3-(4-Methoxyphenyl)-2-[4-(2-oxochromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C22H14N2O3S, CAS 210287-77-7

(E)-3-(4-Methoxyphenyl)-2-[4-(2-oxochromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile

CAS 210287-77-7C₂₂H₁₄N₂O₃S

(E)-3-(2,5-Dimethoxyphenyl)-2-[4-(2-oxochromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C23H16N2O4S, CAS 330181-07-2

(E)-3-(2,5-Dimethoxyphenyl)-2-[4-(2-oxochromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile

CAS 330181-07-2C₂₃H₁₆N₂O₄S

(E)-3-(4-Butoxy-3-methoxyphenyl)-2-[4-(2-oxochromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C26H22N2O4S, CAS 635297-97-1

(E)-3-(4-Butoxy-3-methoxyphenyl)-2-[4-(2-oxochromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile

CAS 635297-97-1C₂₆H₂₂N₂O₄S

(Z)-3-(4-Chlorophenyl)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acrylonitrile chemical structure, C21H11ClN2O2S, CAS 210287-74-4

(Z)-3-(4-Chlorophenyl)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acrylonitrile

CAS 210287-74-4C₂₁H₁₁ClN₂O₂S

(E)-Methyl 4-(2-(4-(6-bromo-2-oxo-2H-chromen-3-yl)thiazol-2-yl)-2-cyanovinyl)benzoate chemical structure, C23H13BrN2O4S, CAS 683250-12-6

(E)-Methyl 4-(2-(4-(6-bromo-2-oxo-2H-chromen-3-yl)thiazol-2-yl)-2-cyanovinyl)benzoate

CAS 683250-12-6C₂₃H₁₃BrN₂O₄S

3-(4-Ethoxyphenyl)-2-(4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl)acrylonitrile chemical structure, C23H16N2O3S, CAS 308101-50-0

3-(4-Ethoxyphenyl)-2-(4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl)acrylonitrile

CAS 308101-50-0C₂₃H₁₆N₂O₃S

(E)-3-(4-Methylphenyl)-2-[4-(2-oxochromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C22H14N2O2S, CAS 326915-14-4

(E)-3-(4-Methylphenyl)-2-[4-(2-oxochromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile

CAS 326915-14-4C₂₂H₁₄N₂O₂S

(E)-4-(2-Cyano-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)vinyl)-2-methoxyphenyl acetate chemical structure, C24H16N2O5S, CAS 683250-36-4

(E)-4-(2-Cyano-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)vinyl)-2-methoxyphenyl acetate

CAS 683250-36-4C₂₄H₁₆N₂O₅S

(E)-3-(2-Methoxy-5-nitrophenyl)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acrylonitrile chemical structure, C22H13N3O5S, CAS 683256-14-6

(E)-3-(2-Methoxy-5-nitrophenyl)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acrylonitrile

CAS 683256-14-6C₂₂H₁₃N₃O₅S

7-(Diethylamino)-3-[2-[(E)-2-phenylethenyl]-1,3-thiazol-4-yl]chromen-2-one chemical structure, C24H22N2O2S, CAS 143102-93-6

7-(Diethylamino)-3-[2-[(E)-2-phenylethenyl]-1,3-thiazol-4-yl]chromen-2-one

CAS 143102-93-6C₂₄H₂₂N₂O₂S

(E)-4-(2-(4-(6-Bromo-2-oxo-2H-chromen-3-yl)thiazol-2-yl)-2-cyanovinyl)-2,6-dimethoxyphenyl acetate chemical structure, C25H17BrN2O6S, CAS 683250-63-7

(E)-4-(2-(4-(6-Bromo-2-oxo-2H-chromen-3-yl)thiazol-2-yl)-2-cyanovinyl)-2,6-dimethoxyphenyl acetate

CAS 683250-63-7C₂₅H₁₇BrN₂O₆S

(2Z)-2-[4-(6-Bromo-2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl]-3-(4-fluorophenyl)prop-2-enenitrile chemical structure, C21H10BrFN2O2S, CAS 415714-06-6

(2Z)-2-[4-(6-Bromo-2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl]-3-(4-fluorophenyl)prop-2-enenitrile

CAS 415714-06-6C₂₁H₁₀BrFN₂O₂S

(2Z)-3-[4-(Dimethylamino)phenyl]-2-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C23H17N3O2S, CAS 210287-79-9

(2Z)-3-[4-(Dimethylamino)phenyl]-2-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile

CAS 210287-79-9C₂₃H₁₇N₃O₂S

(E)-3-(3-Ethoxy-4-isopropoxyphenyl)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acrylonitrile chemical structure, C26H22N2O4S, CAS 1021228-26-1

(E)-3-(3-Ethoxy-4-isopropoxyphenyl)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acrylonitrile

CAS 1021228-26-1C₂₆H₂₂N₂O₄S

(2E)-3-(4-Hydroxy-3-methoxy-5-nitrophenyl)-2-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C22H13N3O6S, CAS 683255-21-2

(2E)-3-(4-Hydroxy-3-methoxy-5-nitrophenyl)-2-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile

CAS 683255-21-2C₂₂H₁₃N₃O₆S

(E)-3-(3-Bromo-4-hydroxy-5-methoxyphenyl)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acrylonitrile chemical structure, C22H13BrN2O4S, CAS 683254-75-3

(E)-3-(3-Bromo-4-hydroxy-5-methoxyphenyl)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acrylonitrile

CAS 683254-75-3C₂₂H₁₃BrN₂O₄S