Murcko scaffold
Ring system with 4 rings and 23 atoms
58 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 23
- Chemicals
- 58
- With full pages
- 14
Scaffold SMILES
c1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3ccnc3)cc2)c1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold c1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3ccnc3)cc2)c1](/scaffold/JVBNNNQTULLPIJ-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 58 chemicals
Losartan
CAS 114798-26-4C22H23ClN6O
DuP 532
CAS 124750-95-4C23H19F5N6O2
Losartan carboxylic acid
CAS 124750-92-1C22H21ClN6O2
2-Propyl-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-4-(trifluoromethyl)-1H-imidazole-5-carboxylic acid
CAS 124750-93-2C22H19F3N6O2
Exp3880
CAS 138330-11-7C21H19F3N6O
Olmesartan
CAS 144689-24-7C24H26N6O3
Elisartan
CAS 149968-26-3C27H29ClN6O5
Exp3312
CAS 114798-35-5C21H19ClN6O
Dmp 811
CAS 139964-19-5C23H24N6O2
Losartan carboxaldehyde
CAS 114798-36-6C22H21ClN6O
Losartan metabolite M2
CAS 141675-57-2C22H23ClN6O2
Dehydro olmesartan
CAS 172875-98-8C24H24N6O2
Losartan metabolite M5
CAS 141675-59-4C22H23ClN6O2
Olmesartan monohydrate
CAS 913529-31-4C24H28N6O4
Hyzaar
CAS 156154-37-9C29H31Cl2N9O5S2
Olmesartan ethyl ester
CAS 144689-23-6C26H30N6O3
![Ethyl 5-prop-1-en-2-yl-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate chemical structure, C26H28N6O2, CAS 172875-87-5](/s/JRUZGUHGYSRJNX-UHFFFAOYSA-N.svg)
Ethyl 5-prop-1-en-2-yl-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate
CAS 172875-87-5C26H28N6O2
Sevikar
CAS 1188913-21-4C44H51ClN8O8
Losartan potassium
CAS 124750-99-8C22H22ClKN6O
![2-Butyl-4-chloro-1-[(2'-(1-H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxylic acid hydrochloride chemical structure, C22H22Cl2N6O2, CAS 913611-26-4](/s/MQEYGHYUCYCJDC-UHFFFAOYSA-N.svg)
2-Butyl-4-chloro-1-[(2'-(1-H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxylic acid hydrochloride
CAS 913611-26-4C22H22Cl2N6O2
Allisartan isoproxil impurity 27
CAS 947331-07-9C26H27ClN6O5
Losartan hydrochloride
CAS 343311-44-4C22H24Cl2N6O
Elisartan potassium
CAS 154568-18-0C27H28ClKN6O5
Allisartan isoproxil impurity 32
CAS 947330-97-4C24H25ClN6O2
- 1 suppliersAllisartan isoproxil947331-05-7C27H29ClN6O5
- 1 suppliers(2-Butyl-4-chloro-1-((2'-(2H-tetrazol-5-yl)(2,3,5,6-~2~H_4_)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazol-5-yl)methanol1030937-27-9C22H23ClN6O
- Losartan-d91030937-18-8C22H23ClN6O
- Losartan methyl ether114798-94-6C23H25ClN6O
- Losartan carboxaldehyde-d31184999-26-5C22H21ClN6O
- Losartan-d31030936-74-3C22H23ClN6O
- Losartan-d3 carboxylic acid1189729-40-5C22H21ClN6O2
- Olmesartan-d6 acid1185144-74-4C24H26N6O3
- Losartan-d4 carboxylic acid1246820-62-1C22H21ClN6O2
- 1 suppliersO-Acetyl losartan1006062-27-6C24H25ClN6O2
- Losartan impurity K1159977-26-0C21H20Cl2N6
- Deshydroxymethyl losartan trifluoroacetic acid salt1215727-33-5C23H22ClF3N6O2
- 1H-Imidazole-4-methanol, 2-butyl-5-chloro-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-114799-13-2C22H23ClN6O
- Losartan impurity 4141949-90-8C22H21ClN6O
- Potassium 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylate143412-42-4C22H20ClKN6O2
- Losartan amine141949-89-5C22H24ClN7
- 5-[2-[4-[[5-(Azidomethyl)-2-butyl-4-chloroimidazol-1-yl]methyl]phenyl]phenyl]-2H-tetrazole727718-93-6C22H22ClN9
- 5-(4'-((2-Butyl-4-chloro-5-(((1-methylethyl)oxy)methyl)-1H-imidazol-1-yl)methyl)biphenyl-2-yl)-1H-tetrazole1332713-64-0C25H29ClN6O
- (R)-Methyl 4-benzyl-6,6-dimethylmorpholine-3-carboxylate hydrochloride2891581-38-5C23H23ClN6O3
- O-Methyl ether olmesartan acid1039762-40-7C25H28N6O3
- Olmesartan impurity 991427168-36-2C27H32N6O3
- 2-Butyl-5-chloro-3-((4-(2-(2-(1-ethoxyethyl)tetrazol-5-yl)phenyl)phenyl)methyl)imidazole-4-carbaldehyde165276-40-4C26H29ClN6O2
- N-1-Ethoxyethyl losartan carboxylic acid165276-41-5C26H29ClN6O3
- Olmesartan methyl ester1347262-29-6C25H28N6O3
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1[nH]ncn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1](/scaffold/KPUKLCJVNHJLDZ-UHFFFAOYSA-N/structure.svg)
![Scaffold c1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3cncn3)cn2)c1](/scaffold/PSGCJWIKUYBWKX-UHFFFAOYSA-N/structure.svg)