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Murcko scaffold

Ring system with 4 rings and 24 atoms

183 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
183
With full pages
13
Scaffold SMILES

O=C(Nc1c2c(nn1-c1ccccc1)CS(=O)C2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1c2c(nn1-c1ccccc1)CS(=O)C2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 183 chemicals

4-Bromo-N-(5-oxido-2-(p-tolyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C19H16BrN3O2S, CAS 958587-45-6
4-Bromo-N-(5-oxido-2-(p-tolyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 958587-45-6C19H16BrN3O2S
4-Bromo-N-(2-(4-fluorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C18H13BrFN3O2S, CAS 958587-46-7
4-Bromo-N-(2-(4-fluorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 958587-46-7C18H13BrFN3O2S
N-[2-(3-Chlorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-fluorobenzamide chemical structure, C18H13ClFN3O2S, CAS 958228-81-4
N-[2-(3-Chlorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-fluorobenzamide
CAS 958228-81-4C18H13ClFN3O2S
2-Fluoro-N-[2-(4-fluorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide chemical structure, C18H13F2N3O2S, CAS 958228-80-3
2-Fluoro-N-[2-(4-fluorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide
CAS 958228-80-3C18H13F2N3O2S
4-Fluoro-N-(2-(4-fluorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C18H13F2N3O2S, CAS 1007192-49-5
4-Fluoro-N-(2-(4-fluorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 1007192-49-5C18H13F2N3O2S
N-(2-(4-Fluorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-nitrobenzamide chemical structure, C18H13FN4O4S, CAS 1008857-95-1
N-(2-(4-Fluorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-nitrobenzamide
CAS 1008857-95-1C18H13FN4O4S
4-tert-Butyl-N-[2-(4-methylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide chemical structure, C23H25N3O2S, CAS 1009599-37-4
4-tert-Butyl-N-[2-(4-methylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide
CAS 1009599-37-4C23H25N3O2S
N-[2-(3-Chlorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2,6-difluorobenzamide chemical structure, C18H12ClF2N3O2S, CAS 1008475-36-2
N-[2-(3-Chlorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2,6-difluorobenzamide
CAS 1008475-36-2C18H12ClF2N3O2S
2-Chloro-6-fluoro-N-[2-(4-fluorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide chemical structure, C18H12ClF2N3O2S, CAS 1009459-54-4
2-Chloro-6-fluoro-N-[2-(4-fluorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide
CAS 1009459-54-4C18H12ClF2N3O2S
N-[2-(4-Fluorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethylbenzamide chemical structure, C20H18FN3O2S, CAS 1007550-69-7
N-[2-(4-Fluorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethylbenzamide
CAS 1007550-69-7C20H18FN3O2S
4-(N,N-Dimethylsulfamoyl)-N-(5-oxido-2-(p-tolyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C21H22N4O4S2, CAS 1008857-96-2
4-(N,N-Dimethylsulfamoyl)-N-(5-oxido-2-(p-tolyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 1008857-96-2C21H22N4O4S2
N-[2-(3-Chlorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,5-dimethylbenzamide chemical structure, C20H18ClN3O2S, CAS 1009518-12-0
N-[2-(3-Chlorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,5-dimethylbenzamide
CAS 1009518-12-0C20H18ClN3O2S
N-(2-(3-Chlorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-ethoxybenzamide chemical structure, C20H18ClN3O3S, CAS 1009696-91-6
N-(2-(3-Chlorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-ethoxybenzamide
CAS 1009696-91-6C20H18ClN3O3S
2-Ethoxy-N-(2-(4-fluorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C20H18FN3O3S, CAS 958702-50-6
2-Ethoxy-N-(2-(4-fluorophenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 958702-50-6C20H18FN3O3S
2-Ethoxy-N-(2-(4-methoxyphenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C21H21N3O4S, CAS 958711-25-6
2-Ethoxy-N-(2-(4-methoxyphenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 958711-25-6C21H21N3O4S
N-[2-(2,3-Dimethylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-ethoxybenzamide chemical structure, C22H23N3O3S, CAS 1008397-65-6
N-[2-(2,3-Dimethylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-2-ethoxybenzamide
CAS 1008397-65-6C22H23N3O3S
N-(2-(2,4-Dimethylphenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-ethoxybenzamide chemical structure, C22H23N3O3S, CAS 1007194-64-0
N-(2-(2,4-Dimethylphenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-ethoxybenzamide
CAS 1007194-64-0C22H23N3O3S
2-Ethoxy-N-(5-oxido-2-(o-tolyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C21H21N3O3S, CAS 958703-35-0
2-Ethoxy-N-(5-oxido-2-(o-tolyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 958703-35-0C21H21N3O3S
3,4-Diethoxy-N-[2-(4-methylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide chemical structure, C23H25N3O4S, CAS 958984-53-7
3,4-Diethoxy-N-[2-(4-methylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide
CAS 958984-53-7C23H25N3O4S
N-[2-(3-Chlorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-diethoxybenzamide chemical structure, C22H22ClN3O4S, CAS 958703-41-8
N-[2-(3-Chlorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-diethoxybenzamide
CAS 958703-41-8C22H22ClN3O4S
3,4-Diethoxy-N-[2-(4-fluorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide chemical structure, C22H22FN3O4S, CAS 958711-29-0
3,4-Diethoxy-N-[2-(4-fluorophenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]benzamide
CAS 958711-29-0C22H22FN3O4S
3,4-Diethoxy-N-(2-(4-methoxyphenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C23H25N3O5S, CAS 1007550-65-3
3,4-Diethoxy-N-(2-(4-methoxyphenyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 1007550-65-3C23H25N3O5S
N-[2-(2,3-Dimethylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-diethoxybenzamide chemical structure, C24H27N3O4S, CAS 1020478-70-9
N-[2-(2,3-Dimethylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-diethoxybenzamide
CAS 1020478-70-9C24H27N3O4S
N-[2-(2,4-Dimethylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-diethoxybenzamide chemical structure, C24H27N3O4S, CAS 1020478-72-1
N-[2-(2,4-Dimethylphenyl)-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-diethoxybenzamide
CAS 1020478-72-1C24H27N3O4S