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Murcko scaffold

Ring system with 5 rings and 28 atoms

19 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 28
Chemicals: 19
With full pages: 5

Scaffold SMILES

O=c1cc(CN2CCN(Cc3ccc4c(c3)OCO4)CC2)c2ccccc2o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1cc(CN2CCN(Cc3ccc4c(c3)OCO4)CC2)c2ccccc2o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-5,7,8-trimethyl-2H-chromen-2-one chemical structure, C25H28N2O4, CAS 850751-22-3

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-5,7,8-trimethyl-2H-chromen-2-one

CAS 850751-22-3C₂₅H₂₈N₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6,8-dimethyl-2H-chromen-2-one chemical structure, C24H26N2O4, CAS 862207-75-8

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6,8-dimethyl-2H-chromen-2-one

CAS 862207-75-8C₂₄H₂₆N₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-5,7-dimethyl-2H-chromen-2-one chemical structure, C24H26N2O4, CAS 877788-97-1

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-5,7-dimethyl-2H-chromen-2-one

CAS 877788-97-1C₂₄H₂₆N₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6,7-dimethyl-2H-chromen-2-one chemical structure, C24H26N2O4, CAS 877795-05-6

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6,7-dimethyl-2H-chromen-2-one

CAS 877795-05-6C₂₄H₂₆N₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-hydroxy-7-methyl-2H-chromen-2-one chemical structure, C23H24N2O5, CAS 859142-50-0

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-hydroxy-7-methyl-2H-chromen-2-one

CAS 859142-50-0C₂₃H₂₄N₂O₅

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7-methoxy-2H-chromen-2-one chemical structure, C23H24N2O5, CAS 859143-76-3

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7-methoxy-2H-chromen-2-one

CAS 859143-76-3C₂₃H₂₄N₂O₅

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-hydroxy-2H-chromen-2-one chemical structure, C22H22N2O5, CAS 859862-56-9

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-hydroxy-2H-chromen-2-one

CAS 859862-56-9C₂₂H₂₂N₂O₅

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-chloro-5,7-dimethyl-2H-chromen-2-one chemical structure, C24H25ClN2O4, CAS 849917-60-8

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-chloro-5,7-dimethyl-2H-chromen-2-one

CAS 849917-60-8C₂₄H₂₅ClN₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-methyl-2H-chromen-2-one chemical structure, C23H24N2O4, CAS 850238-57-2

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-methyl-2H-chromen-2-one

CAS 850238-57-2C₂₃H₂₄N₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one chemical structure, C23H24N2O4, CAS 556019-39-7

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one

CAS 556019-39-7C₂₃H₂₄N₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7,8-dimethyl-2H-chromen-2-one chemical structure, C24H26N2O4, CAS 850900-73-1

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7,8-dimethyl-2H-chromen-2-one

CAS 850900-73-1C₂₄H₂₆N₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-chloro-7-methyl-2H-chromen-2-one chemical structure, C23H23ClN2O4, CAS 862193-74-6

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-chloro-7-methyl-2H-chromen-2-one

CAS 862193-74-6C₂₃H₂₃ClN₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-ethyl-2H-chromen-2-one chemical structure, C24H26N2O4, CAS 877646-03-2

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-ethyl-2H-chromen-2-one

CAS 877646-03-2C₂₄H₂₆N₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-isopropyl-2H-chromen-2-one chemical structure, C25H28N2O4, CAS 862485-11-8

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-isopropyl-2H-chromen-2-one

CAS 862485-11-8C₂₅H₂₈N₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-chloro-2H-chromen-2-one chemical structure, C22H21ClN2O4, CAS 902018-15-9

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-chloro-2H-chromen-2-one

CAS 902018-15-9C₂₂H₂₁ClN₂O₄

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7-hydroxy-8-methyl-2H-chromen-2-one chemical structure, C23H24N2O5, CAS 848182-60-5

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7-hydroxy-8-methyl-2H-chromen-2-one

CAS 848182-60-5C₂₃H₂₄N₂O₅

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-ethyl-7-hydroxy-2H-chromen-2-one chemical structure, C24H26N2O5, CAS 896806-48-7

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-6-ethyl-7-hydroxy-2H-chromen-2-one

CAS 896806-48-7C₂₄H₂₆N₂O₅

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-5-hydroxy-7-methyl-2H-chromen-2-one chemical structure, C23H24N2O5, CAS 896816-22-1

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-5-hydroxy-7-methyl-2H-chromen-2-one

CAS 896816-22-1C₂₃H₂₄N₂O₅

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7,8-dihydroxy-2H-chromen-2-one dihydrochloride chemical structure, C22H24Cl2N2O6, CAS 1177861-22-1

4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7,8-dihydroxy-2H-chromen-2-one dihydrochloride

CAS 1177861-22-1C₂₂H₂₄Cl₂N₂O₆