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Murcko scaffold

Ring system with 3 rings and 17 atoms

109 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 17
Chemicals: 109
With full pages: 17

Scaffold SMILES

O=c1ccoc2c1OC=CC2c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1ccoc2c1OC=CC2c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 109 chemicals

2-Amino-6-(hydroxymethyl)-8-oxo-4-(3,4,5-trimethoxyphenyl)-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C19H18N2O7, CAS 625376-08-1

2-Amino-6-(hydroxymethyl)-8-oxo-4-(3,4,5-trimethoxyphenyl)-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 625376-08-1C₁₉H₁₈N₂O₇

Ethyl 2-amino-4-(2-chloro-6-fluorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carboxylate chemical structure, C18H15ClFNO6, CAS 664999-76-2

Ethyl 2-amino-4-(2-chloro-6-fluorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carboxylate

CAS 664999-76-2C₁₈H₁₅ClFNO₆

2-Amino-6-(hydroxymethyl)-4-(4-isopropoxy-3-methoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C20H20N2O6, CAS 674805-37-9

2-Amino-6-(hydroxymethyl)-4-(4-isopropoxy-3-methoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 674805-37-9C₂₀H₂₀N₂O₆

2-Amino-4-(2,3-dimethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C18H16N2O6, CAS 674805-35-7

2-Amino-4-(2,3-dimethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 674805-35-7C₁₈H₁₆N₂O₆

2-Amino-6-(hydroxymethyl)-8-oxo-4-(2,3,4-trimethoxyphenyl)-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C19H18N2O7, CAS 674805-36-8

2-Amino-6-(hydroxymethyl)-8-oxo-4-(2,3,4-trimethoxyphenyl)-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 674805-36-8C₁₉H₁₈N₂O₇

2-Amino-4-(4-tert-butylphenyl)-6-(hydroxymethyl)-8-oxo-4H-pyrano[3,2-b]pyran-3-carbonitrile chemical structure, C20H20N2O4, CAS 860648-65-3

2-Amino-4-(4-tert-butylphenyl)-6-(hydroxymethyl)-8-oxo-4H-pyrano[3,2-b]pyran-3-carbonitrile

CAS 860648-65-3C₂₀H₂₀N₂O₄

2-Amino-4-(2-ethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C18H16N2O5, CAS 860648-69-7

2-Amino-4-(2-ethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 860648-69-7C₁₈H₁₆N₂O₅

2-Amino-6-(hydroxymethyl)-8-oxo-4-[3-(trifluoromethyl)phenyl]-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C17H11F3N2O4, CAS 695203-79-3

2-Amino-6-(hydroxymethyl)-8-oxo-4-[3-(trifluoromethyl)phenyl]-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 695203-79-3C₁₇H₁₁F₃N₂O₄

2-Amino-6-(hydroxymethyl)-8-oxo-4-[2-(trifluoromethyl)phenyl]-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C17H11F3N2O4, CAS 697246-16-5

2-Amino-6-(hydroxymethyl)-8-oxo-4-[2-(trifluoromethyl)phenyl]-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 697246-16-5C₁₇H₁₁F₃N₂O₄

2-Amino-4-(4-fluorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C16H11FN2O4, CAS 797028-50-3

2-Amino-4-(4-fluorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 797028-50-3C₁₆H₁₁FN₂O₄

2-Amino-6-(hydroxymethyl)-4-(4-isopropylphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C19H18N2O4, CAS 797028-53-6

2-Amino-6-(hydroxymethyl)-4-(4-isopropylphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 797028-53-6C₁₉H₁₈N₂O₄

2-Amino-4,8-dihydro-6-(hydroxymethyl)-4-(4-methoxyphenyl)-8-oxopyrano[3,2-b]pyran-3-carbonitrile chemical structure, C17H14N2O5, CAS 194282-56-9

2-Amino-4,8-dihydro-6-(hydroxymethyl)-4-(4-methoxyphenyl)-8-oxopyrano[3,2-b]pyran-3-carbonitrile

CAS 194282-56-9C₁₇H₁₄N₂O₅

2-Amino-4-(3-fluorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C16H11FN2O4, CAS 876709-71-6

2-Amino-4-(3-fluorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 876709-71-6C₁₆H₁₁FN₂O₄

2-Amino-4-(2-chloro-6-fluorophenyl)-6-(hydroxymethyl)-8-oxo-4H-pyrano[3,2-b]pyran-3-carbonitrile chemical structure, C16H10ClFN2O4, CAS 698977-44-5

2-Amino-4-(2-chloro-6-fluorophenyl)-6-(hydroxymethyl)-8-oxo-4H-pyrano[3,2-b]pyran-3-carbonitrile

CAS 698977-44-5C₁₆H₁₀ClFN₂O₄

2-Amino-6-(hydroxymethyl)-8-oxo-4-(2,4,5-trimethoxyphenyl)-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C19H18N2O7, CAS 876709-77-2

2-Amino-6-(hydroxymethyl)-8-oxo-4-(2,4,5-trimethoxyphenyl)-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 876709-77-2C₁₉H₁₈N₂O₇

2-Amino-6-(hydroxymethyl)-8-oxo-4-phenyl-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C16H12N2O4, CAS 194282-54-7

2-Amino-6-(hydroxymethyl)-8-oxo-4-phenyl-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 194282-54-7C₁₆H₁₂N₂O₄

2-Amino-4-(2,4-dichlorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C16H10Cl2N2O4, CAS 697246-15-4

2-Amino-4-(2,4-dichlorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 697246-15-4C₁₆H₁₀Cl₂N₂O₄

2-Amino-4-(4-ethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C18H16N2O5, CAS 876709-81-8

2-Amino-4-(4-ethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 876709-81-8C₁₈H₁₆N₂O₅

2-Amino-6-(hydroxymethyl)-4-(2-methoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C17H14N2O5, CAS 698977-48-9

2-Amino-6-(hydroxymethyl)-4-(2-methoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 698977-48-9C₁₇H₁₄N₂O₅

2-Amino-4-(2,4-dimethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C18H16N2O6, CAS 876709-84-1

2-Amino-4-(2,4-dimethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 876709-84-1C₁₈H₁₆N₂O₆

2-Amino-4-(3,5-dimethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C18H16N2O6, CAS 876709-87-4

2-Amino-4-(3,5-dimethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 876709-87-4C₁₈H₁₆N₂O₆

2-Amino-4-(2,5-dimethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C18H16N2O6, CAS 876709-89-6

2-Amino-4-(2,5-dimethoxyphenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 876709-89-6C₁₈H₁₆N₂O₆

2-Amino-4-(2,3-dichlorophenyl)-6-(hydroxymethyl)-8-oxo-4H-pyrano[3,2-b]pyran-3-carbonitrile chemical structure, C16H10Cl2N2O4, CAS 698977-40-1

2-Amino-4-(2,3-dichlorophenyl)-6-(hydroxymethyl)-8-oxo-4H-pyrano[3,2-b]pyran-3-carbonitrile

CAS 698977-40-1C₁₆H₁₀Cl₂N₂O₄

2-Amino-6-(hydroxymethyl)-4-(2-methylphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile chemical structure, C17H14N2O4, CAS 876709-95-4

2-Amino-6-(hydroxymethyl)-4-(2-methylphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

CAS 876709-95-4C₁₇H₁₄N₂O₄