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Murcko scaffold

Ring system with 4 rings and 24 atoms

121 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 121
With full pages: 7

Scaffold SMILES

O=C1C(=Cc2ccccc2)Oc2c(CN3CCNCC3)cccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=Cc2ccccc2)Oc2c(CN3CCNCC3)cccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 121 chemicals

(Z)-2-(2,3-Dimethoxybenzylidene)-7-((4-ethylpiperazin-1-yl)methyl)-6-hydroxybenzofuran-3(2H)-one chemical structure, C24H28N2O5, CAS 859131-44-5

(Z)-2-(2,3-Dimethoxybenzylidene)-7-((4-ethylpiperazin-1-yl)methyl)-6-hydroxybenzofuran-3(2H)-one

CAS 859131-44-5C₂₄H₂₈N₂O₅

(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C24H28N2O6, CAS 859132-61-9

(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 859132-61-9C₂₄H₂₈N₂O₆

(Z)-6-Hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C25H30N2O7, CAS 859135-19-6

(Z)-6-Hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one

CAS 859135-19-6C₂₅H₃₀N₂O₇

(Z)-6-Hydroxy-7-((4-methylpiperazin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C24H28N2O6, CAS 859662-39-8

(Z)-6-Hydroxy-7-((4-methylpiperazin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one

CAS 859662-39-8C₂₄H₂₈N₂O₆

(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C23H26N2O5, CAS 859666-31-2

(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 859666-31-2C₂₃H₂₆N₂O₅

(2Z)-2-(4-tert-Butylbenzylidene)-6-hydroxy-7-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-1-benzofuran-3(2H)-one chemical structure, C26H32N2O4, CAS 1177494-33-5

(2Z)-2-(4-tert-Butylbenzylidene)-6-hydroxy-7-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-1-benzofuran-3(2H)-one

CAS 1177494-33-5C₂₆H₃₂N₂O₄

(Z)-7-((4-Ethylpiperazin-1-yl)methyl)-6-hydroxy-2-(4-nitrobenzylidene)benzofuran-3(2H)-one chemical structure, C22H23N3O5, CAS 896807-03-7

(Z)-7-((4-Ethylpiperazin-1-yl)methyl)-6-hydroxy-2-(4-nitrobenzylidene)benzofuran-3(2H)-one

CAS 896807-03-7C₂₂H₂₃N₃O₅

(Z)-2-(3-Chlorobenzylidene)-7-((4-ethylpiperazin-1-yl)methyl)-6-hydroxybenzofuran-3(2H)-one chemical structure, C22H23ClN2O3, CAS 896805-23-5

(Z)-2-(3-Chlorobenzylidene)-7-((4-ethylpiperazin-1-yl)methyl)-6-hydroxybenzofuran-3(2H)-one

CAS 896805-23-5C₂₂H₂₃ClN₂O₃

(Z)-2-(2-Chloro-6-fluorobenzylidene)-7-((4-ethylpiperazin-1-yl)methyl)-6-hydroxybenzofuran-3(2H)-one chemical structure, C22H22ClFN2O3, CAS 896806-36-3

(Z)-2-(2-Chloro-6-fluorobenzylidene)-7-((4-ethylpiperazin-1-yl)methyl)-6-hydroxybenzofuran-3(2H)-one

CAS 896806-36-3C₂₂H₂₂ClFN₂O₃

(Z)-2-(4-Bromobenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C22H23BrN2O4, CAS 896806-60-3

(Z)-2-(4-Bromobenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896806-60-3C₂₂H₂₃BrN₂O₄

(Z)-2-(5-Bromo-2-methoxybenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C22H23BrN2O4, CAS 896808-14-3

(Z)-2-(5-Bromo-2-methoxybenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896808-14-3C₂₂H₂₃BrN₂O₄

(Z)-2-(4-Ethylbenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C24H28N2O4, CAS 896810-59-6

(Z)-2-(4-Ethylbenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896810-59-6C₂₄H₂₈N₂O₄

(Z)-2-(5-Bromo-2-methoxybenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C23H25BrN2O5, CAS 896811-16-8

(Z)-2-(5-Bromo-2-methoxybenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896811-16-8C₂₃H₂₅BrN₂O₅

(Z)-7-((4-Ethylpiperazin-1-yl)methyl)-6-hydroxy-2-(3-nitrobenzylidene)benzofuran-3(2H)-one chemical structure, C22H23N3O5, CAS 896824-22-9

(Z)-7-((4-Ethylpiperazin-1-yl)methyl)-6-hydroxy-2-(3-nitrobenzylidene)benzofuran-3(2H)-one

CAS 896824-22-9C₂₂H₂₃N₃O₅

(Z)-6-Hydroxy-7-((4-methylpiperazin-1-yl)methyl)-2-(4-nitrobenzylidene)benzofuran-3(2H)-one chemical structure, C21H21N3O5, CAS 896835-58-8

(Z)-6-Hydroxy-7-((4-methylpiperazin-1-yl)methyl)-2-(4-nitrobenzylidene)benzofuran-3(2H)-one

CAS 896835-58-8C₂₁H₂₁N₃O₅

(Z)-6-Hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-(3-methylbenzylidene)benzofuran-3(2H)-one chemical structure, C23H26N2O4, CAS 896836-06-9

(Z)-6-Hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-(3-methylbenzylidene)benzofuran-3(2H)-one

CAS 896836-06-9C₂₃H₂₆N₂O₄

(Z)-2-(2-Bromobenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C21H21BrN2O3, CAS 896846-80-3

(Z)-2-(2-Bromobenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896846-80-3C₂₁H₂₁BrN₂O₃

(Z)-2-(3-Fluorobenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C21H21FN2O3, CAS 896850-07-0

(Z)-2-(3-Fluorobenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896850-07-0C₂₁H₂₁FN₂O₃

(Z)-2-(2-Bromobenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C22H23BrN2O4, CAS 896846-94-9

(Z)-2-(2-Bromobenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896846-94-9C₂₂H₂₃BrN₂O₄

(Z)-2-(3-Chlorobenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C22H23ClN2O4, CAS 896850-95-6

(Z)-2-(3-Chlorobenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896850-95-6C₂₂H₂₃ClN₂O₄

(Z)-7-((4-Ethylpiperazin-1-yl)methyl)-6-hydroxy-2-(3-methylbenzylidene)benzofuran-3(2H)-one chemical structure, C23H26N2O3, CAS 896850-62-7

(Z)-7-((4-Ethylpiperazin-1-yl)methyl)-6-hydroxy-2-(3-methylbenzylidene)benzofuran-3(2H)-one

CAS 896850-62-7C₂₃H₂₆N₂O₃

(Z)-6-Hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-(3-nitrobenzylidene)benzofuran-3(2H)-one chemical structure, C22H23N3O6, CAS 896850-61-6

(Z)-6-Hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-(3-nitrobenzylidene)benzofuran-3(2H)-one

CAS 896850-61-6C₂₂H₂₃N₃O₆

(Z)-2-(4-Bromobenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C21H21BrN2O3, CAS 896853-61-5

(Z)-2-(4-Bromobenzylidene)-6-hydroxy-7-((4-methylpiperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896853-61-5C₂₁H₂₁BrN₂O₃

(Z)-2-(3-Bromobenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C22H23BrN2O4, CAS 896854-20-9

(Z)-2-(3-Bromobenzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one

CAS 896854-20-9C₂₂H₂₃BrN₂O₄