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Murcko scaffold

Ring system with 4 rings and 24 atoms

74 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
74
With full pages
1
Scaffold SMILES

O=C1C(=Cc2ccccc2)Oc2c(CN3CCCCC3)cccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccccc2)Oc2c(CN3CCCCC3)cccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 74 chemicals

(Z)-6-Hydroxy-7-((4-methylpiperidin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C25H29NO6, CAS 859133-09-8
(Z)-6-Hydroxy-7-((4-methylpiperidin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859133-09-8C25H29NO6
(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((4-methylpiperidin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C24H27NO5, CAS 859133-61-2
(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((4-methylpiperidin-1-yl)methyl)benzofuran-3(2H)-one
CAS 859133-61-2C24H27NO5
(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one chemical structure, C23H25NO5, CAS 859661-43-1
(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one
CAS 859661-43-1C23H25NO5
(Z)-6-Hydroxy-7-(piperidin-1-ylmethyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C24H27NO6, CAS 859662-80-9
(Z)-6-Hydroxy-7-(piperidin-1-ylmethyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859662-80-9C24H27NO6
(Z)-6-Hydroxy-7-((4-methylpiperidin-1-yl)methyl)-2-(2,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C25H29NO6, CAS 859666-53-8
(Z)-6-Hydroxy-7-((4-methylpiperidin-1-yl)methyl)-2-(2,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859666-53-8C25H29NO6
(Z)-6-Hydroxy-7-(piperidin-1-ylmethyl)-2-(2,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C24H27NO6, CAS 859666-76-5
(Z)-6-Hydroxy-7-(piperidin-1-ylmethyl)-2-(2,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859666-76-5C24H27NO6
(Z)-6-Hydroxy-7-((4-methylpiperidin-1-yl)methyl)-2-(4-nitrobenzylidene)benzofuran-3(2H)-one chemical structure, C22H22N2O5, CAS 896807-88-8
(Z)-6-Hydroxy-7-((4-methylpiperidin-1-yl)methyl)-2-(4-nitrobenzylidene)benzofuran-3(2H)-one
CAS 896807-88-8C22H22N2O5
(Z)-2-(3-Fluorobenzylidene)-6-hydroxy-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one chemical structure, C21H20FNO3, CAS 896822-50-7
(Z)-2-(3-Fluorobenzylidene)-6-hydroxy-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one
CAS 896822-50-7C21H20FNO3
(Z)-6-Hydroxy-2-(3-nitrobenzylidene)-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one chemical structure, C21H20N2O5, CAS 899388-29-5
(Z)-6-Hydroxy-2-(3-nitrobenzylidene)-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one
CAS 899388-29-5C21H20N2O5
(Z)-6-Hydroxy-2-(4-nitrobenzylidene)-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one chemical structure, C21H20N2O5, CAS 900259-17-8
(Z)-6-Hydroxy-2-(4-nitrobenzylidene)-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one
CAS 900259-17-8C21H20N2O5
(Z)-6-Hydroxy-7-((4-methylpiperidin-1-yl)methyl)-2-(3-nitrobenzylidene)benzofuran-3(2H)-one chemical structure, C22H22N2O5, CAS 900281-21-2
(Z)-6-Hydroxy-7-((4-methylpiperidin-1-yl)methyl)-2-(3-nitrobenzylidene)benzofuran-3(2H)-one
CAS 900281-21-2C22H22N2O5
6-Hydroxy-2-[(4-methoxyphenyl)methylene]-7-[(4-methylpiperidyl)methyl]benzo[b] furan-3-one chemical structure, C23H25NO4, CAS 637751-76-9
6-Hydroxy-2-[(4-methoxyphenyl)methylene]-7-[(4-methylpiperidyl)methyl]benzo[b] furan-3-one
CAS 637751-76-9C23H25NO4
(Z)-6-Hydroxy-7-((2-methylpiperidin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C25H29NO6, CAS 859132-31-3
(Z)-6-Hydroxy-7-((2-methylpiperidin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859132-31-3C25H29NO6
(Z)-7-((3,5-Dimethylpiperidin-1-yl)methyl)-6-hydroxy-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C26H31NO6, CAS 859133-65-6
(Z)-7-((3,5-Dimethylpiperidin-1-yl)methyl)-6-hydroxy-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859133-65-6C26H31NO6
(Z)-6-Hydroxy-7-((2-methylpiperidin-1-yl)methyl)-2-(2,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C25H29NO6, CAS 859662-13-8
(Z)-6-Hydroxy-7-((2-methylpiperidin-1-yl)methyl)-2-(2,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859662-13-8C25H29NO6
(Z)-6-Hydroxy-7-((3-methylpiperidin-1-yl)methyl)-2-(2,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C25H29NO6, CAS 859661-23-7
(Z)-6-Hydroxy-7-((3-methylpiperidin-1-yl)methyl)-2-(2,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859661-23-7C25H29NO6
(Z)-7-((3,5-Dimethylpiperidin-1-yl)methyl)-6-hydroxy-2-(3,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C26H31NO6, CAS 859661-82-8
(Z)-7-((3,5-Dimethylpiperidin-1-yl)methyl)-6-hydroxy-2-(3,4,5-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859661-82-8C26H31NO6
(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((2-methylpiperidin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C24H27NO5, CAS 859661-98-6
(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((2-methylpiperidin-1-yl)methyl)benzofuran-3(2H)-one
CAS 859661-98-6C24H27NO5
(Z)-6-Hydroxy-7-((3-methylpiperidin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one chemical structure, C25H29NO6, CAS 859664-21-4
(Z)-6-Hydroxy-7-((3-methylpiperidin-1-yl)methyl)-2-(2,3,4-trimethoxybenzylidene)benzofuran-3(2H)-one
CAS 859664-21-4C25H29NO6
(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((3-methylpiperidin-1-yl)methyl)benzofuran-3(2H)-one chemical structure, C24H27NO5, CAS 859666-74-3
(Z)-2-(2,3-Dimethoxybenzylidene)-6-hydroxy-7-((3-methylpiperidin-1-yl)methyl)benzofuran-3(2H)-one
CAS 859666-74-3C24H27NO5
(Z)-6-Hydroxy-7-((3-methylpiperidin-1-yl)methyl)-2-(4-nitrobenzylidene)benzofuran-3(2H)-one chemical structure, C22H22N2O5, CAS 896814-72-5
(Z)-6-Hydroxy-7-((3-methylpiperidin-1-yl)methyl)-2-(4-nitrobenzylidene)benzofuran-3(2H)-one
CAS 896814-72-5C22H22N2O5
(Z)-6-Hydroxy-2-(4-methylbenzylidene)-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one chemical structure, C22H23NO3, CAS 869077-30-5
(Z)-6-Hydroxy-2-(4-methylbenzylidene)-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one
CAS 869077-30-5C22H23NO3
(Z)-2-(4-Fluorobenzylidene)-6-hydroxy-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one chemical structure, C21H20FNO3, CAS 869077-31-6
(Z)-2-(4-Fluorobenzylidene)-6-hydroxy-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one
CAS 869077-31-6C21H20FNO3
(Z)-2-(2-Fluorobenzylidene)-6-hydroxy-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one chemical structure, C21H20FNO3, CAS 869077-32-7
(Z)-2-(2-Fluorobenzylidene)-6-hydroxy-7-(piperidin-1-ylmethyl)benzofuran-3(2H)-one
CAS 869077-32-7C21H20FNO3