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Murcko scaffold

Ring system with 2 rings and 15 atoms

60 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
60
With full pages
6
Scaffold SMILES

O=C1CC(C(=O)Nc2ccccc2)CN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(C(=O)Nc2ccccc2)CN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 60 chemicals

N-(4-Ethoxyphenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide chemical structure, C16H22N2O3, CAS 591211-81-3
N-(4-Ethoxyphenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide
CAS 591211-81-3C16H22N2O3
N-(4-Chloro-3-nitrophenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide chemical structure, C14H16ClN3O4, CAS 346456-89-1
N-(4-Chloro-3-nitrophenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide
CAS 346456-89-1C14H16ClN3O4
N-(4-Methoxyphenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide chemical structure, C15H20N2O3, CAS 309733-56-0
N-(4-Methoxyphenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide
CAS 309733-56-0C15H20N2O3
N-(4-Bromo-3-methylphenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide chemical structure, C15H19BrN2O2, CAS 510724-39-7
N-(4-Bromo-3-methylphenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide
CAS 510724-39-7C15H19BrN2O2
N-(4-Chlorophenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide chemical structure, C14H17ClN2O2, CAS 404378-22-9
N-(4-Chlorophenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide
CAS 404378-22-9C14H17ClN2O2
N-(3-Chloro-4-fluorophenyl)-1-methyl-5-oxopyrrolidine-3-carboxamide chemical structure, C12H12ClFN2O2, CAS 878738-73-9
N-(3-Chloro-4-fluorophenyl)-1-methyl-5-oxopyrrolidine-3-carboxamide
CAS 878738-73-9C12H12ClFN2O2
N-(4-Bromo-2-fluorophenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide chemical structure, C14H16BrFN2O2, CAS 887677-66-9
N-(4-Bromo-2-fluorophenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide
CAS 887677-66-9C14H16BrFN2O2
N-(5-Chloro-2-methoxyphenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide chemical structure, C15H19ClN2O3, CAS 887677-64-7
N-(5-Chloro-2-methoxyphenyl)-5-oxo-1-propan-2-ylpyrrolidine-3-carboxamide
CAS 887677-64-7C15H19ClN2O3
1-tert-Butyl-N-(3,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C17H24N2O2, CAS 887675-59-4
1-tert-Butyl-N-(3,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 887675-59-4C17H24N2O2
N-(3,5-Dimethylphenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C17H24N2O3, CAS 887677-27-2
N-(3,5-Dimethylphenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 887677-27-2C17H24N2O3
1-tert-Butyl-N-(4-cyanophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H19N3O2, CAS 887675-82-3
1-tert-Butyl-N-(4-cyanophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 887675-82-3C16H19N3O2
1-tert-Butyl-5-oxo-N-[2-(propan-2-yl)phenyl]pyrrolidine-3-carboxamide chemical structure, C18H26N2O2, CAS 896918-17-5
1-tert-Butyl-5-oxo-N-[2-(propan-2-yl)phenyl]pyrrolidine-3-carboxamide
CAS 896918-17-5C18H26N2O2
Ethyl 4-{[(1-tert-butyl-5-oxopyrrolidin-3-yl)carbonyl]amino}benzoate chemical structure, C18H24N2O4, CAS 887675-61-8
Ethyl 4-{[(1-tert-butyl-5-oxopyrrolidin-3-yl)carbonyl]amino}benzoate
CAS 887675-61-8C18H24N2O4
N-(2,5-Dimethylphenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C17H24N2O3, CAS 887677-47-6
N-(2,5-Dimethylphenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 887677-47-6C17H24N2O3
N-(3-Chloro-4-fluorophenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C15H18ClFN2O3, CAS 887677-53-4
N-(3-Chloro-4-fluorophenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 887677-53-4C15H18ClFN2O3
1-tert-Butyl-N-(3-fluorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C15H19FN2O2, CAS 887675-63-0
1-tert-Butyl-N-(3-fluorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 887675-63-0C15H19FN2O2
N-(3,5-Difluorophenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C15H18F2N2O3, CAS 887677-72-7
N-(3,5-Difluorophenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 887677-72-7C15H18F2N2O3
N-(4-Bromophenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C15H19BrN2O3, CAS 887677-35-2
N-(4-Bromophenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 887677-35-2C15H19BrN2O3
N-(2,5-Dichlorophenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C15H18Cl2N2O3, CAS 887677-38-5
N-(2,5-Dichlorophenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 887677-38-5C15H18Cl2N2O3
1-tert-Butyl-N-(4-chloro-2,5-dimethoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C17H23ClN2O4, CAS 896927-13-2
1-tert-Butyl-N-(4-chloro-2,5-dimethoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 896927-13-2C17H23ClN2O4
1-tert-Butyl-N-(4-carbamoylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H21N3O3, CAS 887675-86-7
1-tert-Butyl-N-(4-carbamoylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 887675-86-7C16H21N3O3
N-(3-Chloro-4-methylphenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H21ClN2O3, CAS 887677-59-0
N-(3-Chloro-4-methylphenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 887677-59-0C16H21ClN2O3
1-Methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide chemical structure, C12H14N2O2, CAS 304858-50-2
1-Methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide
CAS 304858-50-2C12H14N2O2
N-(5-Chloro-2-methoxyphenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H21ClN2O4, CAS 892714-49-7
N-(5-Chloro-2-methoxyphenyl)-1-(1-methoxypropan-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 892714-49-7C16H21ClN2O4