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Murcko scaffold

Ring system with 4 rings and 29 atoms

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
10
With full pages
2
Scaffold SMILES

O=C(Cn1c(=O)n(Cc2ccccc2)c(=O)c2ccccc21)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1c(=O)n(Cc2ccccc2)c(=O)c2ccccc21)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

2-(3-Benzyl-2,4-dioxoquinazolin-1-yl)-N-ethyl-N-(3-methylphenyl)acetamide chemical structure, C26H25N3O3, CAS 892295-03-3
2-(3-Benzyl-2,4-dioxoquinazolin-1-yl)-N-ethyl-N-(3-methylphenyl)acetamide
CAS 892295-03-3C26H25N3O3
2-(3-Benzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl)-N-(3-methoxyphenyl)acetamide chemical structure, C24H21N3O4, CAS 892291-72-4
2-(3-Benzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl)-N-(3-methoxyphenyl)acetamide
CAS 892291-72-4C24H21N3O4
2-(3-Benzyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C24H21N3O4, CAS 892291-80-4
2-(3-Benzyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide
CAS 892291-80-4C24H21N3O4
4-((1-(2-((2,4-Dimethylphenyl)amino)-2-oxoethyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)-N-(3-methoxypropyl)benzamide chemical structure, C30H32N4O5, CAS 899920-81-1
4-((1-(2-((2,4-Dimethylphenyl)amino)-2-oxoethyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)-N-(3-methoxypropyl)benzamide
CAS 899920-81-1C30H32N4O5
4-[(1-{[(4-Ethoxyphenyl)carbamoyl]methyl}-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)methyl]-N-(3-methoxypropyl)benzamide chemical structure, C30H32N4O6, CAS 931320-09-1
4-[(1-{[(4-Ethoxyphenyl)carbamoyl]methyl}-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)methyl]-N-(3-methoxypropyl)benzamide
CAS 931320-09-1C30H32N4O6
Ethyl 4-(2-(3-(4-((3-methoxypropyl)carbamoyl)benzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetamido)benzoate chemical structure, C31H32N4O7, CAS 931952-05-5
Ethyl 4-(2-(3-(4-((3-methoxypropyl)carbamoyl)benzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetamido)benzoate
CAS 931952-05-5C31H32N4O7
4-((1-(2-((3,4-Dimethoxyphenyl)amino)-2-oxoethyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)-N-(3-methoxypropyl)benzamide chemical structure, C30H32N4O7, CAS 931360-88-2
4-((1-(2-((3,4-Dimethoxyphenyl)amino)-2-oxoethyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)-N-(3-methoxypropyl)benzamide
CAS 931360-88-2C30H32N4O7
4-{[1-{2-[(4-Ethoxyphenyl)amino]-2-oxoethyl}-6,7-dimethoxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methyl}-N-methylbenzamide chemical structure, C29H30N4O7, CAS 1189653-35-7
4-{[1-{2-[(4-Ethoxyphenyl)amino]-2-oxoethyl}-6,7-dimethoxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methyl}-N-methylbenzamide
CAS 1189653-35-7C29H30N4O7
4-{[1-(2-Anilino-2-oxoethyl)-6,7-dimethoxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methyl}-N-methylbenzamide chemical structure, C27H26N4O6, CAS 1189482-53-8
4-{[1-(2-Anilino-2-oxoethyl)-6,7-dimethoxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methyl}-N-methylbenzamide
CAS 1189482-53-8C27H26N4O6
2-{3-[(2,4-Dichlorophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl}-N-(2,6-dimethylphenyl)acetamide chemical structure, C25H21Cl2N3O3, CAS 2549034-92-4
2-{3-[(2,4-Dichlorophenyl)methyl]-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl}-N-(2,6-dimethylphenyl)acetamide
CAS 2549034-92-4C25H21Cl2N3O3