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Murcko scaffold

5-(Thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one scaffold

17 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
17
With full pages
8
Scaffold SMILES

O=c1[nH]cnc2scc(-c3cccs3)c12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5-(Thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one page
Murcko scaffold O=c1[nH]cnc2scc(-c3cccs3)c12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

5-(Thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one chemical structure, C10H6N2OS2, CAS 215928-54-4
5-(Thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one
CAS 215928-54-4C10H6N2OS2
3-Amino-5-thien-2-ylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C10H7N3OS2, CAS 315684-53-8
3-Amino-5-thien-2-ylthieno[2,3-d]pyrimidin-4(3H)-one
CAS 315684-53-8C10H7N3OS2
3-Amino-2-methyl-5-(2-thienyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C11H9N3OS2, CAS 379244-87-8
3-Amino-2-methyl-5-(2-thienyl)thieno[2,3-d]pyrimidin-4(3H)-one
CAS 379244-87-8C11H9N3OS2
2-[(2-Oxopropyl)sulfanyl]-3-(prop-2-en-1-yl)-5-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C16H14N2O2S3, CAS 379238-93-4
2-[(2-Oxopropyl)sulfanyl]-3-(prop-2-en-1-yl)-5-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one
CAS 379238-93-4C16H14N2O2S3
2-(Chloromethyl)-5-(thiophen-2-yl)-3H,4H-thieno(2,3-d)pyrimidin-4-one chemical structure, C11H7ClN2OS2, CAS 255378-83-7
2-(Chloromethyl)-5-(thiophen-2-yl)-3H,4H-thieno(2,3-d)pyrimidin-4-one
CAS 255378-83-7C11H7ClN2OS2
2-(2-Methyl-4-oxo-5-(thiophen-2-yl)-3H,4H-thieno(2,3-d)pyrimidin-3-yl)acetic acid chemical structure, C13H10N2O3S2, CAS 790272-38-7
2-(2-Methyl-4-oxo-5-(thiophen-2-yl)-3H,4H-thieno(2,3-d)pyrimidin-3-yl)acetic acid
CAS 790272-38-7C13H10N2O3S2
(4-Oxo-5-thien-2-ylthieno[2,3-d]pyrimidin-3(4H)-yl)acetic acid chemical structure, C12H8N2O3S2, CAS 850021-26-0
(4-Oxo-5-thien-2-ylthieno[2,3-d]pyrimidin-3(4H)-yl)acetic acid
CAS 850021-26-0C12H8N2O3S2
2-Methyl-5-(thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one chemical structure, C11H8N2OS2, CAS 243669-49-0
2-Methyl-5-(thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one
CAS 243669-49-0C11H8N2OS2
2-({[4-Oxo-5-(thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-2-yl]methyl}sulfanyl)acetic acid chemical structure, C13H10N2O3S3, CAS 743453-36-3
2-({[4-Oxo-5-(thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-2-yl]methyl}sulfanyl)acetic acid
CAS 743453-36-3C13H10N2O3S3
2-(1-Chloroethyl)-5-(thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one chemical structure, C12H9ClN2OS2, CAS 733031-24-8
2-(1-Chloroethyl)-5-(thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one
CAS 733031-24-8C12H9ClN2OS2
2-(Chloromethyl)-5-(5-methylthien-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C12H9ClN2OS2, CAS 851116-05-7
2-(Chloromethyl)-5-(5-methylthien-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one
CAS 851116-05-7C12H9ClN2OS2
5-(5-Methylthiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one chemical structure, C11H8N2OS2, CAS 851116-03-5
5-(5-Methylthiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one
CAS 851116-03-5C11H8N2OS2
1,4-Dihydro-4-oxo-5-(2-thienyl)thieno[2,3-d]pyrimidine-2-acetonitrile chemical structure, C12H7N3OS2, CAS 243669-50-3
1,4-Dihydro-4-oxo-5-(2-thienyl)thieno[2,3-d]pyrimidine-2-acetonitrile
CAS 243669-50-3C12H7N3OS2
2-(4-Oxo-5-(2-thienyl)thieno[2,3-d]pyrimidin-3(4H)-yl)acetamide chemical structure, C12H9N3O2S2, CAS 1133123-94-0
2-(4-Oxo-5-(2-thienyl)thieno[2,3-d]pyrimidin-3(4H)-yl)acetamide
CAS 1133123-94-0C12H9N3O2S2
2-Chloro-5-(2-thienyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C10H5ClN2OS2, CAS 1420856-90-1
2-Chloro-5-(2-thienyl)thieno[2,3-d]pyrimidin-4(3H)-one
CAS 1420856-90-1C10H5ClN2OS2
2-Amino-5-(2-thienyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C10H7N3OS2, CAS 1216059-62-9
2-Amino-5-(2-thienyl)thieno[2,3-d]pyrimidin-4(3H)-one
CAS 1216059-62-9C10H7N3OS2
Methyl 2-[5-(5-methylthiophen-2-yl)-4-oxo-3H,4H-thieno[2,3-d]pyrimidin-2-yl]acetate chemical structure, C14H12N2O3S2, CAS 2411297-00-0
Methyl 2-[5-(5-methylthiophen-2-yl)-4-oxo-3H,4H-thieno[2,3-d]pyrimidin-2-yl]acetate
CAS 2411297-00-0C14H12N2O3S2