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Murcko scaffold

Pyrazine, 2-phenyl- scaffold

905 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
905
With full pages
25
Scaffold SMILES

c1ccc(-c2cnccn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Pyrazine, 2-phenyl- page
Murcko scaffold c1ccc(-c2cnccn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 905 chemicals

2,3-Dicyano-5-phenylpyrazine chemical structure, C12H6N4, CAS 52109-66-7
2,3-Dicyano-5-phenylpyrazine
CAS 52109-66-7C12H6N4
2,3-Dicyano-5-methyl-6-phenylpyrazine chemical structure, C13H8N4, CAS 52109-67-8
2,3-Dicyano-5-methyl-6-phenylpyrazine
CAS 52109-67-8C13H8N4
2,3-Pyrazinedicarbonitrile, 5-(3-chlorophenyl)-6-(propylamino)- chemical structure, C15H12ClN5, CAS 72113-45-2
2,3-Pyrazinedicarbonitrile, 5-(3-chlorophenyl)-6-(propylamino)-
CAS 72113-45-2C15H12ClN5
2,3-Dichloro-5-phenylpyrazine chemical structure, C10H6Cl2N2, CAS 32493-80-4
2,3-Dichloro-5-phenylpyrazine
CAS 32493-80-4C10H6Cl2N2
3-Chloro-5-phenylpyrazine-2-carbonitrile chemical structure, C11H6ClN3, CAS 181284-10-6
3-Chloro-5-phenylpyrazine-2-carbonitrile
CAS 181284-10-6C11H6ClN3
2-Amino-5-phenylpyrazine chemical structure, C10H9N3, CAS 13535-13-2
2-Amino-5-phenylpyrazine
CAS 13535-13-2C10H9N3
Pyrazine, 2-phenyl- chemical structure, C10H8N2, CAS 29460-97-7
Pyrazine, 2-phenyl-
CAS 29460-97-7C10H8N2
5-(4-Chlorophenyl)pyrazine-2,3-dicarbonitrile chemical structure, C12H5ClN4, CAS 67823-08-9
5-(4-Chlorophenyl)pyrazine-2,3-dicarbonitrile
CAS 67823-08-9C12H5ClN4
5-(3,4-Dimethoxyphenyl)-3-methoxy-2-pyrazinecarbonitrile chemical structure, C14H13N3O3, CAS 85575-21-9
5-(3,4-Dimethoxyphenyl)-3-methoxy-2-pyrazinecarbonitrile
CAS 85575-21-9C14H13N3O3
6-(3,4-Dimethoxyphenyl)-3-methoxy-2-pyrazinecarbonitrile chemical structure, C14H13N3O3, CAS 85575-20-8
6-(3,4-Dimethoxyphenyl)-3-methoxy-2-pyrazinecarbonitrile
CAS 85575-20-8C14H13N3O3
5-(3,4-Dimethoxyphenyl)pyrazine-2,3-dicarbonitrile chemical structure, C14H10N4O2, CAS 67170-61-0
5-(3,4-Dimethoxyphenyl)pyrazine-2,3-dicarbonitrile
CAS 67170-61-0C14H10N4O2
Pyrazinecarbonitrile, 5-(3,4-dimethoxyphenyl)- chemical structure, C13H11N3O2, CAS 91028-38-5
Pyrazinecarbonitrile, 5-(3,4-dimethoxyphenyl)-
CAS 91028-38-5C13H11N3O2
6-(3,4-Dimethoxyphenyl)pyrazine-2-carbonitrile chemical structure, C13H11N3O2, CAS 76177-51-0
6-(3,4-Dimethoxyphenyl)pyrazine-2-carbonitrile
CAS 76177-51-0C13H11N3O2
2-Chloro-3-phenylpyrazine chemical structure, C10H7ClN2, CAS 41270-65-9
2-Chloro-3-phenylpyrazine
CAS 41270-65-9C10H7ClN2
3-Amino-6-phenylpyrazine-2-carboxamide chemical structure, C11H10N4O, CAS 113120-69-7
3-Amino-6-phenylpyrazine-2-carboxamide
CAS 113120-69-7C11H10N4O
2-Chloro-5-phenylpyrazine chemical structure, C10H7ClN2, CAS 25844-73-9
2-Chloro-5-phenylpyrazine
CAS 25844-73-9C10H7ClN2
3-Phenyl-2-pyrazinecarboxylic acid chemical structure, C11H8N2O2, CAS 2881-85-8
3-Phenyl-2-pyrazinecarboxylic acid
CAS 2881-85-8C11H8N2O2
2-Phenyl-5-propylpyrazine chemical structure, C13H14N2, CAS 94021-40-6
2-Phenyl-5-propylpyrazine
CAS 94021-40-6C13H14N2
2,3-Pyrazinedicarbonitrile, 5-(4-methoxyphenyl)- chemical structure, C13H8N4O, CAS 67170-60-9
2,3-Pyrazinedicarbonitrile, 5-(4-methoxyphenyl)-
CAS 67170-60-9C13H8N4O
4-(Pyrazin-2-yl)benzaldehyde chemical structure, C11H8N2O, CAS 127406-08-0
4-(Pyrazin-2-yl)benzaldehyde
CAS 127406-08-0C11H8N2O
3-(Pyrazin-2-yl)benzaldehyde chemical structure, C11H8N2O, CAS 887344-35-6
3-(Pyrazin-2-yl)benzaldehyde
CAS 887344-35-6C11H8N2O
2-[4-(Trifluoromethyl)phenyl]pyrazine chemical structure, C11H7F3N2, CAS 380626-88-0
2-[4-(Trifluoromethyl)phenyl]pyrazine
CAS 380626-88-0C11H7F3N2
2-Amino-3-cyano-5-phenylpyrazine chemical structure, C11H8N4, CAS 50627-25-3
2-Amino-3-cyano-5-phenylpyrazine
CAS 50627-25-3C11H8N4
2-Chloro-6-phenylpyrazine chemical structure, C10H7ClN2, CAS 41270-62-6
2-Chloro-6-phenylpyrazine
CAS 41270-62-6C10H7ClN2