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Murcko scaffold

1-Phenylisoquinoline scaffold

156 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
156
With full pages
14
Scaffold SMILES

c1ccc(-c2nccc3ccccc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylisoquinoline page
Murcko scaffold c1ccc(-c2nccc3ccccc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 156 chemicals

1-(2-Fluorophenyl)isoquinoline-3-carboxylic acid chemical structure, C16H10FNO2, CAS 89242-23-9
1-(2-Fluorophenyl)isoquinoline-3-carboxylic acid
CAS 89242-23-9C16H10FNO2
1-(2-Chlorophenyl)-7-methylisoquinoline-3-carboxylic acid chemical structure, C17H12ClNO2, CAS 89242-28-4
1-(2-Chlorophenyl)-7-methylisoquinoline-3-carboxylic acid
CAS 89242-28-4C17H12ClNO2
7-Chloro-1-(2-chlorophenyl)isoquinoline-3-carboxylic acid chemical structure, C16H9Cl2NO2, CAS 89242-32-0
7-Chloro-1-(2-chlorophenyl)isoquinoline-3-carboxylic acid
CAS 89242-32-0C16H9Cl2NO2
1-(4-Chlorophenyl)isoquinoline-3-carboxylic acid chemical structure, C16H10ClNO2, CAS 89242-40-0
1-(4-Chlorophenyl)isoquinoline-3-carboxylic acid
CAS 89242-40-0C16H10ClNO2
Ethyl 1-(2-chlorophenyl)isoquinoline-3-carboxylate chemical structure, C18H14ClNO2, CAS 89242-07-9
Ethyl 1-(2-chlorophenyl)isoquinoline-3-carboxylate
CAS 89242-07-9C18H14ClNO2
N,N-Dimethyl-2-((1-phenylisoquinolin-3-yl)oxy)ethanamine chemical structure, C19H20N2O, CAS 89721-41-5
N,N-Dimethyl-2-((1-phenylisoquinolin-3-yl)oxy)ethanamine
CAS 89721-41-5C19H20N2O
N,N-Dimethyl-2-{[1-(2-methylphenyl)isoquinolin-3-yl]oxy}ethan-1-amine chemical structure, C20H22N2O, CAS 89721-15-3
N,N-Dimethyl-2-{[1-(2-methylphenyl)isoquinolin-3-yl]oxy}ethan-1-amine
CAS 89721-15-3C20H22N2O
N,N-Dimethyl-2-{[1-(3-methylphenyl)isoquinolin-3-yl]oxy}ethan-1-amine chemical structure, C20H22N2O, CAS 89707-18-6
N,N-Dimethyl-2-{[1-(3-methylphenyl)isoquinolin-3-yl]oxy}ethan-1-amine
CAS 89707-18-6C20H22N2O
2-((1-(4-Chlorophenyl)isoquinolin-3-yl)oxy)-N,N-diethylethanamine chemical structure, C21H23ClN2O, CAS 89707-20-0
2-((1-(4-Chlorophenyl)isoquinolin-3-yl)oxy)-N,N-diethylethanamine
CAS 89707-20-0C21H23ClN2O
2-{[1-(2-Chlorophenyl)isoquinolin-3-yl]oxy}-N,N-dimethylethan-1-amine chemical structure, C19H19ClN2O, CAS 89721-17-5
2-{[1-(2-Chlorophenyl)isoquinolin-3-yl]oxy}-N,N-dimethylethan-1-amine
CAS 89721-17-5C19H19ClN2O
N-Butyl-N-{2-[(1-phenylisoquinolin-3-yl)oxy]ethyl}butan-1-amine chemical structure, C25H32N2O, CAS 89707-22-2
N-Butyl-N-{2-[(1-phenylisoquinolin-3-yl)oxy]ethyl}butan-1-amine
CAS 89707-22-2C25H32N2O
N,N-Dimethyl-2-[(6-methyl-1-phenylisoquinolin-3-yl)oxy]ethan-1-amine chemical structure, C20H22N2O, CAS 89707-26-6
N,N-Dimethyl-2-[(6-methyl-1-phenylisoquinolin-3-yl)oxy]ethan-1-amine
CAS 89707-26-6C20H22N2O
2-[(6-Chloro-1-phenylisoquinolin-3-yl)oxy]-N,N-diethylethan-1-amine chemical structure, C21H23ClN2O, CAS 89707-28-8
2-[(6-Chloro-1-phenylisoquinolin-3-yl)oxy]-N,N-diethylethan-1-amine
CAS 89707-28-8C21H23ClN2O
N,N-Diethyl-2-{[1-(2-methylphenyl)isoquinolin-3-yl]oxy}ethan-1-amine chemical structure, C22H26N2O, CAS 89707-34-6
N,N-Diethyl-2-{[1-(2-methylphenyl)isoquinolin-3-yl]oxy}ethan-1-amine
CAS 89707-34-6C22H26N2O
2-{[1-(2-Fluorophenyl)isoquinolin-3-yl]oxy}-N,N-dimethylethan-1-amine chemical structure, C19H19FN2O, CAS 89721-19-7
2-{[1-(2-Fluorophenyl)isoquinolin-3-yl]oxy}-N,N-dimethylethan-1-amine
CAS 89721-19-7C19H19FN2O
N-Methyl-2-((1-phenylisoquinolin-3-yl)oxy)ethanamine chemical structure, C18H18N2O, CAS 89721-23-3
N-Methyl-2-((1-phenylisoquinolin-3-yl)oxy)ethanamine
CAS 89721-23-3C18H18N2O
2-((1-Phenylisoquinolin-3-yl)oxy)ethanamine chemical structure, C17H16N2O, CAS 89721-25-5
2-((1-Phenylisoquinolin-3-yl)oxy)ethanamine
CAS 89721-25-5C17H16N2O
N,N-Dimethyl-2-[(1-phenylisoquinolin-3-yl)oxy]propan-1-amine chemical structure, C20H22N2O, CAS 89721-45-9
N,N-Dimethyl-2-[(1-phenylisoquinolin-3-yl)oxy]propan-1-amine
CAS 89721-45-9C20H22N2O
N,N-Diethyl-2-[(1-phenylisoquinolin-3-yl)oxy]ethan-1-amine chemical structure, C21H24N2O, CAS 89707-30-2
N,N-Diethyl-2-[(1-phenylisoquinolin-3-yl)oxy]ethan-1-amine
CAS 89707-30-2C21H24N2O
N,N-Diethyl-2-[(1-phenylisoquinolin-3-yl)sulfanyl]ethan-1-amine chemical structure, C21H24N2S, CAS 89707-32-4
N,N-Diethyl-2-[(1-phenylisoquinolin-3-yl)sulfanyl]ethan-1-amine
CAS 89707-32-4C21H24N2S
N,N-Diethyl-2-{[1-(2-methylphenyl)isoquinolin-3-yl]sulfanyl}ethan-1-amine chemical structure, C22H26N2S, CAS 89707-36-8
N,N-Diethyl-2-{[1-(2-methylphenyl)isoquinolin-3-yl]sulfanyl}ethan-1-amine
CAS 89707-36-8C22H26N2S
N,N-Dimethyl-2-[(1-phenylisoquinolin-3-yl)sulfanyl]ethan-1-amine chemical structure, C19H20N2S, CAS 89721-27-7
N,N-Dimethyl-2-[(1-phenylisoquinolin-3-yl)sulfanyl]ethan-1-amine
CAS 89721-27-7C19H20N2S
N,N-Diethyl-2-{[1-(2-fluorophenyl)isoquinolin-3-yl]sulfanyl}ethan-1-amine chemical structure, C21H23FN2S, CAS 89707-45-9
N,N-Diethyl-2-{[1-(2-fluorophenyl)isoquinolin-3-yl]sulfanyl}ethan-1-amine
CAS 89707-45-9C21H23FN2S
1-Phenyl-4-isoquinolinecarbonyl chloride chemical structure, C16H10ClNO, CAS 90829-20-2
1-Phenyl-4-isoquinolinecarbonyl chloride
CAS 90829-20-2C16H10ClNO