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Murcko scaffold

1,4-Dihydro-2H-isoquinolin-3-one scaffold

132 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
132
With full pages
8
Scaffold SMILES

O=C1Cc2ccccc2CN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Dihydro-2H-isoquinolin-3-one page
Murcko scaffold O=C1Cc2ccccc2CN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 132 chemicals

3(2H)-Isoquinolinone, 1,4-dihydro-2-(methylamino)- chemical structure, C10H12N2O, CAS 39191-73-6
3(2H)-Isoquinolinone, 1,4-dihydro-2-(methylamino)-
CAS 39191-73-6C10H12N2O
1,4-Dihydro-2H-isoquinolin-3-one chemical structure, C9H9NO, CAS 24331-94-0
1,4-Dihydro-2H-isoquinolin-3-one
CAS 24331-94-0C9H9NO
2-Amino-1,4-dihydro-3(2H)-isoquinolinone chemical structure, C9H10N2O, CAS 39113-02-5
2-Amino-1,4-dihydro-3(2H)-isoquinolinone
CAS 39113-02-5C9H10N2O
Acetamide, N-(3-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl)- chemical structure, C11H12N2O2, CAS 39113-16-1
Acetamide, N-(3-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl)-
CAS 39113-16-1C11H12N2O2
Urea, 1-(3-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl)- chemical structure, C10H11N3O2, CAS 39113-24-1
Urea, 1-(3-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl)-
CAS 39113-24-1C10H11N3O2
6,7-Dimethoxy-1,4-dihydroisoquinolin-3(2H)-one chemical structure, C11H13NO3, CAS 21763-07-5
6,7-Dimethoxy-1,4-dihydroisoquinolin-3(2H)-one
CAS 21763-07-5C11H13NO3
Ethyl 2-(7-methyl-3-oxo-2,4-dihydro-1H-isoquinolin-6-yl)acetate chemical structure, C14H17NO3, CAS 55329-68-5
Ethyl 2-(7-methyl-3-oxo-2,4-dihydro-1H-isoquinolin-6-yl)acetate
CAS 55329-68-5C14H17NO3
Methyl 2-acetamido-3-oxo-1,4-dihydroisoquinoline-1-carboxylate chemical structure, C13H14N2O4, CAS 63500-01-6
Methyl 2-acetamido-3-oxo-1,4-dihydroisoquinoline-1-carboxylate
CAS 63500-01-6C13H14N2O4
2-Acetamido-3-oxo-1,4-dihydroisoquinoline-1-carboxamide chemical structure, C12H13N3O3, CAS 63500-06-1
2-Acetamido-3-oxo-1,4-dihydroisoquinoline-1-carboxamide
CAS 63500-06-1C12H13N3O3
Methyl 2-amino-3-oxo-1,4-dihydroisoquinoline-1-carboxylate chemical structure, C11H12N2O3, CAS 63499-95-6
Methyl 2-amino-3-oxo-1,4-dihydroisoquinoline-1-carboxylate
CAS 63499-95-6C11H12N2O3
3(2H)-Isoquinolinone, 1,4-dihydro-2-(dimethylamino)-, monohydrochloride chemical structure, C11H15ClN2O, CAS 85588-50-7
3(2H)-Isoquinolinone, 1,4-dihydro-2-(dimethylamino)-, monohydrochloride
CAS 85588-50-7C11H15ClN2O
1,1-Dimethyl-1,2-dihydroisoquinolin-3(4H)-one chemical structure, C11H13NO, CAS 476172-97-1
1,1-Dimethyl-1,2-dihydroisoquinolin-3(4H)-one
CAS 476172-97-1C11H13NO
1-Ethyl-1-methyl-1,2-dihydroisoquinolin-3(4H)-one chemical structure, C12H15NO, CAS 476172-98-2
1-Ethyl-1-methyl-1,2-dihydroisoquinolin-3(4H)-one
CAS 476172-98-2C12H15NO
2-Methyl-1,2,3,4-tetrahydroisoquinolin-3-one chemical structure, C10H11NO, CAS 6798-05-6
2-Methyl-1,2,3,4-tetrahydroisoquinolin-3-one
CAS 6798-05-6C10H11NO
3(2H)-Isoquinolinone,2-ethenyl-4-ethyl-1,4-dihydro- chemical structure, C13H15NO, CAS 423118-91-6
3(2H)-Isoquinolinone,2-ethenyl-4-ethyl-1,4-dihydro-
CAS 423118-91-6C13H15NO
1-Methyl-1,2-dihydroisoquinolin-3(4H)-one chemical structure, C10H11NO, CAS 36073-92-4
1-Methyl-1,2-dihydroisoquinolin-3(4H)-one
CAS 36073-92-4C10H11NO
1-Ethyl-1,4-dihydroisoquinolin-3(2H)-one chemical structure, C11H13NO, CAS 61923-72-6
1-Ethyl-1,4-dihydroisoquinolin-3(2H)-one
CAS 61923-72-6C11H13NO
1-Propyl-1,4-dihydroisoquinolin-3(2H)-one chemical structure, C12H15NO, CAS 61924-15-0
1-Propyl-1,4-dihydroisoquinolin-3(2H)-one
CAS 61924-15-0C12H15NO
7-Hydroxy-1,2,3,4-tetrahydroisoquinolin-3-one chemical structure, C9H9NO2, CAS 53389-81-4
7-Hydroxy-1,2,3,4-tetrahydroisoquinolin-3-one
CAS 53389-81-4C9H9NO2
5-Hydroxy-1,2-dihydroisoquinolin-3(4H)-one chemical structure, C9H9NO2, CAS 53389-82-5
5-Hydroxy-1,2-dihydroisoquinolin-3(4H)-one
CAS 53389-82-5C9H9NO2
Methyl (3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)carbamate chemical structure, C11H12N2O3, CAS 74581-13-8
Methyl (3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)carbamate
CAS 74581-13-8C11H12N2O3
2-Ethyl-1,4-dihydroisoquinolin-3(2H)-one chemical structure, C11H13NO, CAS 69213-62-3
2-Ethyl-1,4-dihydroisoquinolin-3(2H)-one
CAS 69213-62-3C11H13NO
1,4-Dihydro-6,7-dimethoxy-2-methyl-3(2H)-isoquinolinone chemical structure, C12H15NO3, CAS 16135-42-5
1,4-Dihydro-6,7-dimethoxy-2-methyl-3(2H)-isoquinolinone
CAS 16135-42-5C12H15NO3
2-Ethyl-6,7-dimethoxy-1,4-dihydroisoquinolin-3(2H)-one chemical structure, C13H17NO3, CAS 89192-70-1
2-Ethyl-6,7-dimethoxy-1,4-dihydroisoquinolin-3(2H)-one
CAS 89192-70-1C13H17NO3