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Murcko scaffold

5-Benzylpyrimidin-4(3H)-one scaffold

79 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
79
With full pages
13
Scaffold SMILES

O=c1[nH]cncc1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5-Benzylpyrimidin-4(3H)-one page
Murcko scaffold O=c1[nH]cncc1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 79 chemicals

Benzoic acid, 4-((2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinyl)methyl)- chemical structure, C12H11N3O4, CAS 80305-92-6
Benzoic acid, 4-((2-amino-1,4-dihydro-6-hydroxy-4-oxo-5-pyrimidinyl)methyl)-
CAS 80305-92-6C12H11N3O4
2-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-4-one chemical structure, C14H17N3O4, CAS 92440-76-1
2-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidin-4-one
CAS 92440-76-1C14H17N3O4
5-(4-Ethoxybenzyl)-4,6-pyrimidinediol chemical structure, C13H14N2O3, CAS 16015-99-9
5-(4-Ethoxybenzyl)-4,6-pyrimidinediol
CAS 16015-99-9C13H14N2O3
5-[(5-Acetyl-2-methoxyphenyl)methyl]-4-hydroxy-2-methylsulfanyl-1H-pyrimidin-6-one chemical structure, C15H16N2O4S, CAS 78927-67-0
5-[(5-Acetyl-2-methoxyphenyl)methyl]-4-hydroxy-2-methylsulfanyl-1H-pyrimidin-6-one
CAS 78927-67-0C15H16N2O4S
2-Amino-5-(4-ethoxybenzyl)pyrimidine-4,6-diol chemical structure, C13H15N3O3, CAS 5835-61-0
2-Amino-5-(4-ethoxybenzyl)pyrimidine-4,6-diol
CAS 5835-61-0C13H15N3O3
4-Hydroxy-5-[[4-(2-methylpropoxy)phenyl]methyl]-2-methylsulfanyl-1H-pyrimidin-6-one chemical structure, C16H20N2O3S, CAS 23212-14-8
4-Hydroxy-5-[[4-(2-methylpropoxy)phenyl]methyl]-2-methylsulfanyl-1H-pyrimidin-6-one
CAS 23212-14-8C16H20N2O3S
2,3-Diamino-5-benzyl-6-methyl-4(3H)-pyrimidinone chemical structure, C12H14N4O, CAS 103109-34-8
2,3-Diamino-5-benzyl-6-methyl-4(3H)-pyrimidinone
CAS 103109-34-8C12H14N4O
2-Amino-5-(3-methyl-4-propoxy-benzyl)-pyrimidine-4,6-diol chemical structure, C15H19N3O3, CAS 332414-25-2
2-Amino-5-(3-methyl-4-propoxy-benzyl)-pyrimidine-4,6-diol
CAS 332414-25-2C15H19N3O3
1-(3-{[4,6-Dihydroxy-2-(methylsulfanyl)-5-pyrimidinyl]methyl}-4-propoxyphenyl)ethanone chemical structure, C17H20N2O4S, CAS 78927-69-2
1-(3-{[4,6-Dihydroxy-2-(methylsulfanyl)-5-pyrimidinyl]methyl}-4-propoxyphenyl)ethanone
CAS 78927-69-2C17H20N2O4S
5-[(5-Acetyl-2-butoxyphenyl)methyl]-4-hydroxy-2-methylsulfanyl-1H-pyrimidin-6-one chemical structure, C18H22N2O4S, CAS 78927-71-6
5-[(5-Acetyl-2-butoxyphenyl)methyl]-4-hydroxy-2-methylsulfanyl-1H-pyrimidin-6-one
CAS 78927-71-6C18H22N2O4S
5-(3-Methyl-4-propoxybenzyl)-2-(methylsulfanyl)-4,6-pyrimidinediol chemical structure, C16H20N2O3S, CAS 332414-23-0
5-(3-Methyl-4-propoxybenzyl)-2-(methylsulfanyl)-4,6-pyrimidinediol
CAS 332414-23-0C16H20N2O3S
5-[(4-Butoxyphenyl)methyl]-4-hydroxy-2-methylsulfanyl-1H-pyrimidin-6-one chemical structure, C16H20N2O3S, CAS 23212-13-7
5-[(4-Butoxyphenyl)methyl]-4-hydroxy-2-methylsulfanyl-1H-pyrimidin-6-one
CAS 23212-13-7C16H20N2O3S
5-Benzyl-2-(butylthio)-6-hydroxy-4(3H)-pyrimidinone chemical structure, C15H18N2O2S, CAS 5373-35-3
5-Benzyl-2-(butylthio)-6-hydroxy-4(3H)-pyrimidinone
CAS 5373-35-3C15H18N2O2S
5-(4-Methoxybenzyl)-4,6-pyrimidinediol chemical structure, C12H12N2O3, CAS 16015-98-8
5-(4-Methoxybenzyl)-4,6-pyrimidinediol
CAS 16015-98-8C12H12N2O3
2-[(5-Benzyl-4-hydroxy-6-oxo-1H-pyrimidin-2-yl)sulfanyl]hexanoic acid chemical structure, C17H20N2O4S, CAS 500146-87-2
2-[(5-Benzyl-4-hydroxy-6-oxo-1H-pyrimidin-2-yl)sulfanyl]hexanoic acid
CAS 500146-87-2C17H20N2O4S
2-Amino-5-benzylpyrimidine-4,6-diol chemical structure, C11H11N3O2, CAS 331971-28-9
2-Amino-5-benzylpyrimidine-4,6-diol
CAS 331971-28-9C11H11N3O2
5-Benzyl-2-methylsulfanyl-1H-pyrimidin-6-one chemical structure, C12H12N2OS, CAS 73717-80-3
5-Benzyl-2-methylsulfanyl-1H-pyrimidin-6-one
CAS 73717-80-3C12H12N2OS
2-Amino-5-(4-hydroxy-3,5-dimethoxybenzyl)pyrimidin-4(3H)-one chemical structure, C13H15N3O4, CAS 72920-13-9
2-Amino-5-(4-hydroxy-3,5-dimethoxybenzyl)pyrimidin-4(3H)-one
CAS 72920-13-9C13H15N3O4
5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone chemical structure, C13H14N2O2S, CAS 63204-40-0
5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone
CAS 63204-40-0C13H14N2O2S
2-Amino-5-[(4-methoxyphenyl)methyl]-4(3H)-pyrimidinone chemical structure, C12H13N3O2, CAS 24610-43-3
2-Amino-5-[(4-methoxyphenyl)methyl]-4(3H)-pyrimidinone
CAS 24610-43-3C12H13N3O2
2-Methylthio-5-(4-bromobenzyl)pyrimid-4-one chemical structure, C12H11BrN2OS, CAS 93234-95-8
2-Methylthio-5-(4-bromobenzyl)pyrimid-4-one
CAS 93234-95-8C12H11BrN2OS
2-Amino-5-benzyl-4-hydroxypyrimidine chemical structure, C11H11N3O, CAS 873409-32-6
2-Amino-5-benzyl-4-hydroxypyrimidine
CAS 873409-32-6C11H11N3O
5-Benzylpyrimidin-4(3H)-one chemical structure, C11H10N2O, CAS 960298-99-1
5-Benzylpyrimidin-4(3H)-one
CAS 960298-99-1C11H10N2O
2-(5-Benzyl-4-methyl-6-oxopyrimidin-1(6H)-yl)acetic acid chemical structure, C14H14N2O3, CAS 1707571-67-2
2-(5-Benzyl-4-methyl-6-oxopyrimidin-1(6H)-yl)acetic acid
CAS 1707571-67-2C14H14N2O3