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Murcko scaffold

Ring system with 2 rings and 22 atoms

50 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
22
Chemicals
50
With full pages
4
Scaffold SMILES

O=C(CNS(=O)(=O)C=Cc1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNS(=O)(=O)C=Cc1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

N-[4-(Difluoromethoxy)phenyl]-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide chemical structure, C18H18F2N2O4S, CAS 745788-93-6
N-[4-(Difluoromethoxy)phenyl]-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide
CAS 745788-93-6C18H18F2N2O4S
N-(3-Chlorophenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide chemical structure, C17H17ClN2O3S, CAS 851108-83-3
N-(3-Chlorophenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide
CAS 851108-83-3C17H17ClN2O3S
N-(2,4-Dimethylphenyl)-2-[N-(3-methylbutyl)-2-phenylethenesulfonamido]acetamide chemical structure, C23H30N2O3S, CAS 731819-41-3
N-(2,4-Dimethylphenyl)-2-[N-(3-methylbutyl)-2-phenylethenesulfonamido]acetamide
CAS 731819-41-3C23H30N2O3S
N-(3-Chloro-4-fluorophenyl)-2-[N-(prop-2-en-1-yl)-2-phenylethenesulfonamido]acetamide chemical structure, C19H18ClFN2O3S, CAS 732294-73-4
N-(3-Chloro-4-fluorophenyl)-2-[N-(prop-2-en-1-yl)-2-phenylethenesulfonamido]acetamide
CAS 732294-73-4C19H18ClFN2O3S
2-(N-Butyl-2-phenylethenesulfonamido)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C21H23F3N2O3S, CAS 742088-98-8
2-(N-Butyl-2-phenylethenesulfonamido)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 742088-98-8C21H23F3N2O3S
N-(2,6-Difluorophenyl)-2-(N-ethyl-2-phenylethenesulfonamido)acetamide chemical structure, C18H18F2N2O3S, CAS 852032-55-4
N-(2,6-Difluorophenyl)-2-(N-ethyl-2-phenylethenesulfonamido)acetamide
CAS 852032-55-4C18H18F2N2O3S
N-(4-Bromophenyl)-2-(N-ethyl-2-phenylethenesulfonamido)acetamide chemical structure, C18H19BrN2O3S, CAS 852032-56-5
N-(4-Bromophenyl)-2-(N-ethyl-2-phenylethenesulfonamido)acetamide
CAS 852032-56-5C18H19BrN2O3S
N-(4-Acetamidophenyl)-2-(N-ethyl-2-phenylethenesulfonamido)acetamide chemical structure, C20H23N3O4S, CAS 852035-54-2
N-(4-Acetamidophenyl)-2-(N-ethyl-2-phenylethenesulfonamido)acetamide
CAS 852035-54-2C20H23N3O4S
N-(2-Methylphenyl)-2-(N-propyl-2-phenylethenesulfonamido)acetamide chemical structure, C20H24N2O3S, CAS 793680-64-5
N-(2-Methylphenyl)-2-(N-propyl-2-phenylethenesulfonamido)acetamide
CAS 793680-64-5C20H24N2O3S
N-(2,4-Dimethoxyphenyl)-2-(N-propyl-2-phenylethenesulfonamido)acetamide chemical structure, C21H26N2O5S, CAS 1808367-48-7
N-(2,4-Dimethoxyphenyl)-2-(N-propyl-2-phenylethenesulfonamido)acetamide
CAS 1808367-48-7C21H26N2O5S
N-(2-tert-Butylphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide chemical structure, C21H26N2O3S, CAS 848833-68-1
N-(2-tert-Butylphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide
CAS 848833-68-1C21H26N2O3S
N-[4-(Acetamidosulfonyl)phenyl]-2-(2-phenylethenesulfonamido)propanamide chemical structure, C19H21N3O6S2, CAS 1031784-77-6
N-[4-(Acetamidosulfonyl)phenyl]-2-(2-phenylethenesulfonamido)propanamide
CAS 1031784-77-6C19H21N3O6S2
N-(3-Methoxyphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide chemical structure, C18H20N2O4S, CAS 851798-42-0
N-(3-Methoxyphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide
CAS 851798-42-0C18H20N2O4S
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-(N-methyl-2-phenylethenesulfonamido)acetamide chemical structure, C18H16ClF3N2O3S, CAS 796124-48-6
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-(N-methyl-2-phenylethenesulfonamido)acetamide
CAS 796124-48-6C18H16ClF3N2O3S
N-(4-Methoxyphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide chemical structure, C18H20N2O4S, CAS 1147489-85-7
N-(4-Methoxyphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide
CAS 1147489-85-7C18H20N2O4S
N-[4-(Cyanomethyl)phenyl]-2-(N-methyl-2-phenylethenesulfonamido)acetamide chemical structure, C19H19N3O3S, CAS 930471-80-0
N-[4-(Cyanomethyl)phenyl]-2-(N-methyl-2-phenylethenesulfonamido)acetamide
CAS 930471-80-0C19H19N3O3S
N-(3-Bromophenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide chemical structure, C17H17BrN2O3S, CAS 929979-48-6
N-(3-Bromophenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide
CAS 929979-48-6C17H17BrN2O3S
N-(4-Ethoxyphenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide chemical structure, C19H22N2O4S, CAS 930964-48-0
N-(4-Ethoxyphenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide
CAS 930964-48-0C19H22N2O4S
2-(N-Methyl-2-phenylethenesulfonamido)-N-(3-nitrophenyl)acetamide chemical structure, C17H17N3O5S, CAS 924863-87-6
2-(N-Methyl-2-phenylethenesulfonamido)-N-(3-nitrophenyl)acetamide
CAS 924863-87-6C17H17N3O5S
N-(3-Chloro-4-methylphenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide chemical structure, C18H19ClN2O3S, CAS 930669-13-9
N-(3-Chloro-4-methylphenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide
CAS 930669-13-9C18H19ClN2O3S
N-(5-Chloro-2-methoxyphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide chemical structure, C18H19ClN2O4S, CAS 930651-73-3
N-(5-Chloro-2-methoxyphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide
CAS 930651-73-3C18H19ClN2O4S
N-(3-Chloro-4-fluorophenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide chemical structure, C17H16ClFN2O3S, CAS 930759-59-4
N-(3-Chloro-4-fluorophenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide
CAS 930759-59-4C17H16ClFN2O3S
N-(2-Methoxy-5-methylphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide chemical structure, C19H22N2O4S, CAS 930680-38-9
N-(2-Methoxy-5-methylphenyl)-2-(N-methyl-2-phenylethenesulfonamido)acetamide
CAS 930680-38-9C19H22N2O4S
N-(3-Chloro-4-methoxyphenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide chemical structure, C18H19ClN2O4S, CAS 931013-86-4
N-(3-Chloro-4-methoxyphenyl)-2-[methyl-[(E)-2-phenylethenyl]sulfonylamino]acetamide
CAS 931013-86-4C18H19ClN2O4S