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Murcko scaffold

Ring system with 2 rings and 21 atoms

352 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
21
Chemicals
352
With full pages
264
Scaffold SMILES

O=C(CNC(=O)c1ccccc1)NN=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNC(=O)c1ccccc1)NN=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 352 chemicals

Hippuric (4-methoxybenzylidene)hydrazide chemical structure, C17H17N3O3, CAS 137204-99-0
Hippuric (4-methoxybenzylidene)hydrazide
CAS 137204-99-0C17H17N3O3
4-[[[2-[(3,4-Dimethoxybenzoyl)amino]acetyl]hydrazinylidene]methyl]benzoic acid chemical structure, C19H19N3O6, CAS 5587-66-6
4-[[[2-[(3,4-Dimethoxybenzoyl)amino]acetyl]hydrazinylidene]methyl]benzoic acid
CAS 5587-66-6C19H19N3O6
N-(2-(2-(2-HO-3-Methoxybenzylidene)hydrazino)-2-oxoethyl)-3,4-dimethoxybenzamide chemical structure, C19H21N3O6, CAS 322664-90-4
N-(2-(2-(2-HO-3-Methoxybenzylidene)hydrazino)-2-oxoethyl)-3,4-dimethoxybenzamide
CAS 322664-90-4C19H21N3O6
Glycine, N-(3-methylbenzoyl)-, [(4-hydroxyphenyl)methylene]hydrazide chemical structure, C17H17N3O3, CAS 444193-02-6
Glycine, N-(3-methylbenzoyl)-, [(4-hydroxyphenyl)methylene]hydrazide
CAS 444193-02-6C17H17N3O3
4-Chloro-N-[1-[2-[(5-chloro-2-hydroxyphenyl)methylidene]hydrazinyl]-4-methyl-1-oxopentan-2-yl]benzamide chemical structure, C20H21Cl2N3O3
4-Chloro-N-[1-[2-[(5-chloro-2-hydroxyphenyl)methylidene]hydrazinyl]-4-methyl-1-oxopentan-2-yl]benzamide
C20H21Cl2N3O3
N-[1-[2-[(4-Butoxy-3-methoxyphenyl)methylidene]hydrazinyl]-3-methyl-1-oxobutan-2-yl]-4-fluorobenzamide chemical structure, C24H30FN3O4, CAS 5862-08-8
N-[1-[2-[(4-Butoxy-3-methoxyphenyl)methylidene]hydrazinyl]-3-methyl-1-oxobutan-2-yl]-4-fluorobenzamide
CAS 5862-08-8C24H30FN3O4
4-Chloro-N-[1-[2-[(3-methoxy-4-propan-2-yloxyphenyl)methylidene]hydrazinyl]-3-methyl-1-oxobutan-2-yl]benzamide chemical structure, C23H28ClN3O4, CAS 5856-34-8
4-Chloro-N-[1-[2-[(3-methoxy-4-propan-2-yloxyphenyl)methylidene]hydrazinyl]-3-methyl-1-oxobutan-2-yl]benzamide
CAS 5856-34-8C23H28ClN3O4
N-(1-{2-[(4-Butoxy-3-ethoxyphenyl)methylidene]hydrazinyl}-3-methyl-1-oxobutan-2-yl)-3,4-dichlorobenzamide chemical structure, C25H31Cl2N3O4, CAS 5856-22-4
N-(1-{2-[(4-Butoxy-3-ethoxyphenyl)methylidene]hydrazinyl}-3-methyl-1-oxobutan-2-yl)-3,4-dichlorobenzamide
CAS 5856-22-4C25H31Cl2N3O4
N-(4-Dimethylamino-benzylidene-hydrazinocarbonylmethyl)-3-methoxy-benzamide chemical structure, C19H22N4O3, CAS 324032-49-7
N-(4-Dimethylamino-benzylidene-hydrazinocarbonylmethyl)-3-methoxy-benzamide
CAS 324032-49-7C19H22N4O3
N-(2-(2-(4-(Dimethylamino)benzylidene)hydrazino)-2-oxoethyl)-4-fluorobenzamide chemical structure, C18H19FN4O2, CAS 324032-47-5
N-(2-(2-(4-(Dimethylamino)benzylidene)hydrazino)-2-oxoethyl)-4-fluorobenzamide
CAS 324032-47-5C18H19FN4O2
4-Fluoro-N-(2-oxo-2-(2-(3,4,5-trimethoxybenzylidene)hydrazino)ethyl)benzamide chemical structure, C19H20FN3O5, CAS 765278-17-9
4-Fluoro-N-(2-oxo-2-(2-(3,4,5-trimethoxybenzylidene)hydrazino)ethyl)benzamide
CAS 765278-17-9C19H20FN3O5
N-(2-{(2E)-2-[4-(dimethylamino)benzylidene]hydrazino}-2-oxoethyl)benzamide chemical structure, C18H20N4O2, CAS 199856-20-7
N-(2-{(2E)-2-[4-(dimethylamino)benzylidene]hydrazino}-2-oxoethyl)benzamide
CAS 199856-20-7C18H20N4O2
N-(2-(2-(3-Bromobenzylidene)hydrazino)-2-oxoethyl)-3,4-dimethoxybenzamide chemical structure, C18H18BrN3O4, CAS 324033-60-5
N-(2-(2-(3-Bromobenzylidene)hydrazino)-2-oxoethyl)-3,4-dimethoxybenzamide
CAS 324033-60-5C18H18BrN3O4
N-(2-(2-Benzylidenehydrazino)-2-oxoethyl)-3,4-dimethoxybenzamide chemical structure, C18H19N3O4, CAS 324014-12-2
N-(2-(2-Benzylidenehydrazino)-2-oxoethyl)-3,4-dimethoxybenzamide
CAS 324014-12-2C18H19N3O4
(E)-N-(2-(2-(2-Fluorobenzylidene)hydrazinyl)-2-oxoethyl)benzamide chemical structure, C16H14FN3O2, CAS 321966-88-5
(E)-N-(2-(2-(2-Fluorobenzylidene)hydrazinyl)-2-oxoethyl)benzamide
CAS 321966-88-5C16H14FN3O2
N-{2-[2-(4-Bromobenzylidene)hydrazino]-2-oxoethyl}benzamide chemical structure, C16H14BrN3O2, CAS 329049-28-7
N-{2-[2-(4-Bromobenzylidene)hydrazino]-2-oxoethyl}benzamide
CAS 329049-28-7C16H14BrN3O2
3,4,5-Trimethoxy-N-(2-(2-(3-methoxybenzylidene)hydrazino)-2-oxoethyl)benzamide chemical structure, C20H23N3O6, CAS 391883-17-3
3,4,5-Trimethoxy-N-(2-(2-(3-methoxybenzylidene)hydrazino)-2-oxoethyl)benzamide
CAS 391883-17-3C20H23N3O6
Methyl 4-(2-(((3,4-dimethoxybenzoyl)amino)acetyl)carbohydrazonoyl)benzoate chemical structure, C20H21N3O6, CAS 507249-71-0
Methyl 4-(2-(((3,4-dimethoxybenzoyl)amino)acetyl)carbohydrazonoyl)benzoate
CAS 507249-71-0C20H21N3O6
2-[2-[(E)-[[2-[(4-Fluorobenzoyl)amino]acetyl]hydrazinylidene]methyl]phenoxy]acetic acid chemical structure, C18H16FN3O5, CAS 372497-49-9
2-[2-[(E)-[[2-[(4-Fluorobenzoyl)amino]acetyl]hydrazinylidene]methyl]phenoxy]acetic acid
CAS 372497-49-9C18H16FN3O5
N-(2-(2-(4-Chlorobenzylidene)hydrazino)-2-oxoethyl)-3-methylbenzamide chemical structure, C17H16ClN3O2, CAS 391877-61-5
N-(2-(2-(4-Chlorobenzylidene)hydrazino)-2-oxoethyl)-3-methylbenzamide
CAS 391877-61-5C17H16ClN3O2
3-Methyl-N-(2-oxo-2-(2-(3,4,5-trimethoxybenzylidene)hydrazino)ethyl)benzamide chemical structure, C20H23N3O5, CAS 391877-71-7
3-Methyl-N-(2-oxo-2-(2-(3,4,5-trimethoxybenzylidene)hydrazino)ethyl)benzamide
CAS 391877-71-7C20H23N3O5
(E)-N-(2-(2-(4-Bromobenzylidene)hydrazinyl)-2-oxoethyl)-2-(trifluoromethyl)benzamide chemical structure, C17H13BrF3N3O2, CAS 391878-70-9
(E)-N-(2-(2-(4-Bromobenzylidene)hydrazinyl)-2-oxoethyl)-2-(trifluoromethyl)benzamide
CAS 391878-70-9C17H13BrF3N3O2
(E)-N-(2-(2-(2,4-Dichlorobenzylidene)hydrazinyl)-2-oxoethyl)-2-(trifluoromethyl)benzamide chemical structure, C17H12Cl2F3N3O2, CAS 391878-74-3
(E)-N-(2-(2-(2,4-Dichlorobenzylidene)hydrazinyl)-2-oxoethyl)-2-(trifluoromethyl)benzamide
CAS 391878-74-3C17H12Cl2F3N3O2
(E)-4-(N,N-Diethylsulfamoyl)-N-(2-(2-(2-methoxybenzylidene)hydrazinyl)-2-oxoethyl)benzamide chemical structure, C21H26N4O5S, CAS 391885-15-7
(E)-4-(N,N-Diethylsulfamoyl)-N-(2-(2-(2-methoxybenzylidene)hydrazinyl)-2-oxoethyl)benzamide
CAS 391885-15-7C21H26N4O5S